(Available online: 1 August 2018)
Vol 7, No 2 (2018): (Available online: 1 August 2018)
Agus Eka Wiradiputra I Ketut Suyasa Putu Astawa Ketut Siki Kawiyana
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Work-related psychological distress and social dysfunction in Nurses at Haji Hospital Medan-Indonesia
Novy Prasanty M. Surya Husada Elmeida Effendy Muhammad Joesoef Simbolon
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Ganglion Cell Complex thickness as an early predictor of microstructural changes in varying degrees of myopia in comparison with Retinal Nerve Fiber Layer (RNFL) thickness
Andi Pratiwi Machmud Andi Muhammad Ichsan Habibah Setyawati Muhiddin
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Rapid action to avoid cataract blindness in South Sulawesi
Habibah Setyawati Muhiddin Ahmad Ashraf Amalius George Ade Novra Sitanaya Dyah Ayu Windy
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Testosterone increases corpus cavernous smooth muscle cells in oxidative stress-induced rodents (Sprague-Dawley)
I Nyoman Gede Wardana IGA Widianti Gede Wirata
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Bioequivalence study of dihydroartemisinin-piperaquine (DHP) generic formulation in fixed-dose combination, in healthy Indonesian volunteers
Ani Isnawati Retno Gitawati Mariana Raini Indri Rooslamiati Lanny Marliany Effi Setiawati Vivi Setiawaty
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Agile design of public hospitals in Iran
Ghahraman Mahmoudi Mohammad Ali Jahani Masoomeh Abdi Mousa Yaminfirooz Mohammad Amin Bahrami
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Plasma miR-135a; a potential biomarker for diagnosis of new type 2 diabetes (T2DM)
Mohamad Reza Sarookhani Maryam Honardoost Farshad Foroughi Yousef Khazaei Monfared
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Cranial nerve disorder on nasopharyngeal cancer patient at Dr.Kariadi Hospital Semarang 2014-2016
Dwi Antono Muyassaroh Muyassaroh Rully Satriawan Rachma Purnama Sari
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Effect of glomerulosclerosis index, tubular index, and matrix metalloprotein against serum creatinine and estimated glomerular filtration rate in obstructive kidney stone patients in Sanglah General Hospital Denpasar-Bali
Oka A. A. G Sun Fu
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Correlation between Quality of Work Life (QWL) with Nurse productivity in inpatient room Bhayangkara Tk III Hospital Manado
Natalia G Wara Starry H Rampengan Martha Korompis
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Higher endometrial receptivity caused by Letrozole in antagonist protocol-stimulated mouse uterus
A. A. N. Anantasika K. Suwiyoga I. M. Bakta I. N. M. Astawa
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Operative Nuances of Endoscopic Third Ventriculostomy for Pediatric Obstructive Hydrocephalus
Dewa Putu Wisnu Wardhana Sri Maliawan
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The relationship between spiritual intelligence, life expectancy, and self- regulation among high school students
Najaf Tahmasbipour Sadegh Nasri Zahra Rafieeyazd
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The effect of slow-stroke back massage on anxiety in female patients with heart failure
Fatemeh Mohaddes Narges Ghaderi Ehsanpour Tahereh Najafi Ghezeljeh
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Medicine reminder to improve treatment compliance on geriatric patients with diabetic neuropathy at Sanglah Central Hospital, Bali-Indonesia
Ida Ayu Manik Partha Sutema Made Krisna Adi Jaya I Made Bakta
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The rationale of surgical treatment in pediatric spine tuberculosis
Komang Agung Irianto
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Effective methods in preventing plagiarism in medical research: A qualitative study at Tabriz University of Medical Sciences-Iran
Nayer Soltany Mohammadhiwa Abdekhoda Shafi Habibi
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Association between premature canities and quality of life at Medan, Indonesia 2017
Putri Ashraf Nelva K Jusuf Rointan Simanungkalit
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Impacts of endometrioma type and two-different techniques of laparoscopic cystectomyon ovarian reserve by measuring anti-mullerian hormone concentration
Ida Bagus Putra Adnyana
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Adult Idiopathic Scoliosis: Correction or not?
Tjokorda GB Mahadewa
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Measuring the nurses’ professional self-concept and its correlation with working stress in Iranian educational Hospitals
Razieh Montazeralfaraj Montazeralfaraj Elham Ahmadi Ahmadi Arefeh Dehghani Tafti Tafti Omid Barati Mohammad Amin Bahrami
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The relationship between emotional intelligence with general health and academic achievement: a case study in Iran’s Health system
Mohammad Ranjbar Razieh Montazerfaraj Mastoureh Pourmahmoodian
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Cost for traffic accident related injuries and its comparison it with the national standard: A case study in Iran
Somayeh Mahdiyan Mahdiyan Kavos Asgari Asgari Mohammad Ranjbar
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Utilization of Medical Education research studies: A survey among participants in Iranian National Conference on Medical Education
Tahereh Changiz Alireza Yousefy Mohammad Fakhari
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Evaluating Hospital safety index in Susa public hospital: An action research study
Ahmad Reza Raeisi Amin Torabipour Leyla Karimi
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The effect of educational Intervention based on Health Belief Model (HBM) on the promotion of teachers social capital in Baft in 2015
Rahmatolah Dadvar Mohammad Hossein Baghianimoghadam Seyyed Saeed Mazloomi
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The effect of red guava juice (Psidium guajava Linn.) in decreasing uric acid and creatinine levels of white mice (Mus musculus) with hyperuricemia
F. W. Aprillinda D. Paramasari W. Brian
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Association between high survivin expression and late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma
Rosalina Susantio Mahendra Dewi Susraini N
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Sexual function of post-episiotomy mother’s measured using Female Sexual Function Index at Haji Adam Malik Hospital and other networking Hospitals in Medan-Indonesia
Muhammad Wahyu Utomo M Rhiza Z Tala Iman Helmi Effendi Ganis Siregar Herbert Sihite Johny Marpaung
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The addition of dates palm (Phoenix dactylifera) on iron supplementation (Fe) increases the hemoglobin level of adolescent girls with anemia
Arum Sari Eti Poncorini Pamungkasari Yulia Lanti Retno Dewi
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Improving the quality of positioning and reducing the rotation factor during pediatric portable chest radiography using infant immobilizer
Alireza Mahmoudabadi Majid Sadeghi Moghadam Moosa Sajjadi Majid Shams Leila Ameri
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Clinical, radiological features, and surgical management of spontaneous intracerebral hemorrhage patients in East Nusa Tenggara-Indonesia
Yustinus Robby Budiman Gondowardojo Donny Argie Achmad Adam Ni Luh Made Novi Ratnasari
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Restoration of erythrocyte microrheological peculiarities in 5-6-year-old children with scoliosis after daily usage of medioprophylactic clothes for six months
AA Bikbulatova E.G. Andreeva I.N Medvedev
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Diagnostics of erythrocytes' early microrheological abnormalities in rats with experimentally developed obesity
Svetlana Zavalishina et al. Vatnikov Yu.A Kubatbekov T.S Kulikov E.V Nikishov A.A Drukovsky S.G Khomenets N.G Zaykova E.Yu Aleshin M.V Dinchenko O.I Glagoleva T.I
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Hemolytic anemia incident in leprosy patients receiving multi-drug therapy at Haji Adam Malik Central Hospital, Medan-Indonesia.
Wan Tisya Muhaira Mila Darmi Ramona Dumasari Lubis
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Radiodermatitis incidents in cancer patients receiving radiotherapy at Haji Adam Malik Central Hospital, Medan-Indonesia
Monalisa Manik Ariyati Yosi Chairiyah Tanjung
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Dermatophytes and bacterial superinfectives in tinea pedis patients at Haji Adam Malik Central Hospital, Medan-Indonesia
E. Heriawati Sitepu Kamaliah Muis Imam Budi Putra
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Ultrasound findings in knee osteoarthritis and rheumatoid arthritis compared to MRI
Hamidreza Sadeghian Babak Shekarchi Mohsen Zahedi Niya Hamed Bagheri
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Effects of jogging and breakfast consumption on weight changes in overweight high school students at Surakarta-Indonesia
Alifiyanti Muharramah Muchsin Doewes Didik Gunawan Tamtomo
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Urological complications following obstetric-gynecologic procedures at Sanglah General Hospital, Bali-Indonesia
Kadek Budi Santosa Pande Made Wisnu Tirtayasa Anak Agung Gede Oka
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Sequential (Sepsis-Related) Organ Failure Assessment (SOFA) as a predictor of mortality and its correlation with capillary lactate levels in sepsis patients
Made Susila Utama Candra Lasmono Tuti Parwati Merati
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miRNA-124 Loaded Chitosan as Novel Therapy to Induce Neuroprotective and Neurogenesis for Improving Brain Revitalization after Ischemic Stroke
Rataya Paramitha Maliawan Sieny Veronica Ni Putu Ayu Pande Arista Dewi Putu Wisnu Arya Wardana Dewa Putu Wisnu Wardhana Sri Maliawan
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Serum markers of Inflammatory Bowel Disease: A literature review
Siti Muchayat Purnamaningsih
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Reconstruction of a severe open distal humerus fracture and intercondylar fracture with complete loss of 13 cm humeral bone by using a free vascularized fibular graft: A case report
Kadek Yuris Wira Artha AA Gede Yuda Asmara
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Hyperbaric oxygen effects towards SIRT1 level in Sprague dawley with endothelial dysfunction by high-cholesterol diet
Herin Setianingsih Soetjipto Soetjipto I Ketut Sudiana M Guritno Suryokusumo
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Annual The 3rd International Symposium in Scientific Writing and Publication Meeting
Ida Bagus Putra Adnyana
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Astaxanthin increase osteocytes, osteoblasts, decrease adipocytes cells, and reduces osteonecrotic events in femoral head of Wistar rats exposed to alcohol.
Agus Eka Wiradiputra, I Ketut Suyasa, Putu Astawa, Ketut Siki KawiyanaAstaxanthin increase osteocytes, osteoblasts, decrease adipocytes cells, and reduces osteonecrotic events in femoral head of Wistar rats exposed to alcohol.
Background: Osteonecrosis is the death of bone cells that can be associated with alcohol abuse. Alcohol abuse has been projected to increase by 0.6% every year. The high morbidity and cost of therapy of osteonecrosis necessitate the effort to prevent osteonecrosis before it manifested. Astaxanthin is an antioxidant that is expected to increase the number of osteocyte and osteoblast cells, decrease the number of adipocyte cells, and reduce the incidence of osteonecrosis.
Methods: This is an experimental randomized post-test control only group design. A total of 24 Wistar rats who met the inclusion criteria were randomly assigned to the control group with the administration of alcohol and the treatment group with the administration of alcohol and astaxanthin. The number of osteocytes, osteoblasts, adipocytes, and osteonecrosis occurrence was examined in the first, second, and third week.
Results: Statistical analysis showed a lower average number of osteoblast cells in the control group (38+1.43) than in the treatment group (55.63±2.17) with astaxanthin administration. The same results can also be seen in the number of osteocyte cells in the control group (16.69±0.94) as compared with the treatment group (28.06±1.26). Meanwhile, the average number of adipocyte cells in the control group showed a higher yield (58.69±1.18) when compared with the treatment group (27.50±1,24). The occurrence of osteonecrosis, as depicted by the presence of empty lacunae and necrotic osteocyte cells, showed the highest increase in osteonecrosis occurrence at week 3 (34.56±0.31) of the control group. While in the treatment group, the decrease in the incidence of osteonecrosis showed the lowest number in week 3 (4.75±0.79). The statistical analysis test using one-way ANOVA showed that the mean difference between treatment and control groups was statistically significant (p <0.05).
Conclusions: The above calculation showed that administration of astaxanthin could decrease the incidence of osteonecrosis in the femoral head of rats exposed to alcohol.
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Work-related psychological distress and social dysfunction in Nurses at Haji Hospital Medan-Indonesia
Novy Prasanty, M. Surya Husada, Elmeida Effendy, Muhammad Joesoef SimbolonWork-related psychological distress and social dysfunction in Nurses at Haji Hospital Medan-Indonesia
Background: The concept of "stress” has been growing for a long time and has attracted a lot of attention, behaviour, and philosophy of many people in the world. Nowadays, stress has become a popular topic among health care professionals. Nurses are assumed to have heavy and various workloads. The nursing workload is influenced by stressors that can cause stress. At some level, psychological, physiological and sociological symptoms might appear. Job stress related to work stress factors include role ambiguity, role conflict, quantitative work overload, career development, and responsibility toward others, which have an impact on psychological distress and social dysfunction.
Objective: This study aims to determine the psychological distress and social dysfunction in nurses related to job stressors in Haji Hospital Medan.
Method: This research was an analytic research with a cross-sectional method using total sampling of 186 nurses who are still working in Haji Medan Hospital. The instruments used were the Stress Diagnostic Survey to measure work stress and GHQ12 to measure psychological distress and social dysfunction. The statistical tests used were Pearson correlation test (for a normal distribution) and Spearman (for non-normal distribution).
Results: There was a significant relationship between total work stressors and psychological distress (p = 0.0001), also, a weak positive correlation (r = 0.364) showed that total work stressors and psychological distress would increase together. The relation between total work stressors and social dysfunction was statistically significant (p = 0.018) and a very weak negative correlation (r = -0.173) was found, meaning that an increase in total job stress score would lower the social dysfunction score.
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Ganglion Cell Complex thickness as an early predictor of microstructural changes in varying degrees of myopia in comparison with Retinal Nerve Fiber Layer (RNFL) thickness
Andi Pratiwi Machmud, Andi Muhammad Ichsan, Habibah Setyawati MuhiddinGanglion Cell Complex thickness as an early predictor of microstructural changes in varying degrees of myopia in comparison with Retinal Nerve Fiber Layer (RNFL) thickness
Purpose : To compare the Ganglion Cell Complex (GCC) thickness with Retinal Nerve Fiber Layer
(RNFL) thickness in correlation with visual field (VF) in varying degrees of myopia. Design: a Cross-
Sectional study. Participants: Ninety-six eyes of 49 patients with myopia. Methods: Patients with
myopia examined with streak retinoscope to obtained the best corrected visual acuity based on
spherical equivalent. Patients then divided into low (50 eyes=50.1%), moderate (31 eyes=32.3%), and
high (15=15.6%) myopia. Axial length measured with A-Scan ultrasound divided into short (4=4.2%),
moderate (74=77.1%), and long (18=18.7%). SD-OCT was used to measured GCC thickness in 9 areas
including fovea (R1), parafovea (R2-R5), and perifovea (R6-R9) according to early treatment diabetic
retinopathy study (ETDRS), and RNFL thickness in five areas (G, TS, TI, NS, N, NI). VF analysis
with humphrey field analyzer with SITA 24-2 pattern. Main outcome measures: GCC thickness has
higher correlation with degree of myopia particularly in perifovea area and means deviation than
RNFL thickness. Results: GCC thickness decreased significantly along with the elevation of myopia
degree in almost entire area except R1 and R5 . Parafovea (R2-R4) and perifovea (R6-R9) were
significantly correlated with p= 0.001, 0.005, 0.006 and p= 0.000, 0.000, 0.000, and 0.003
respectively. In contrast, RNFL thickness obtained lower correlation with myopia degree whereas the
only significant result was found in Nasal area (p= 0.045). VF found to be strongly correlated with the
degree of myopia in which p-value for Mean Deviation = 0.000. Conclusions: GCC thickness may
compare the predictive value of RNFL in predicting early retinal microstructural changes even in low
degree myopia. Financial Disclosure: Author has no financial disclosure.
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Rapid action to avoid cataract blindness in South Sulawesi
Habibah Setyawati Muhiddin, Ahmad Ashraf Amalius, George Ade Novra Sitanaya, Dyah Ayu WindyRapid action to avoid cataract blindness in South Sulawesi
Background: RAAB 2013 reported the prevalence of bilateral blindness in South Sulawesi is 2,6%, with the main causes of blindness is cataract (64.3%). This report describes the crash program for cataract blindness control in South Sulawesi within the last 3 years (2014 - 2016). Material and Methods: Collecting the data of cataract infrastructures, human resources, and cataract surgical rate (CSR) from each district in South Sulawesi. From these data, we conduct statistical analysis and crash program planning, establish special and regional teams, and perform advocacy to stake holders of each district to describe the condition of the eye health services and action plans for cataract blindness prevention in each district. Results: The number of cataract surgery in South Sulawesi was 13.988 with CSR 1.753 in 2014. The number of cataract surgery in 2015 and 2016 was increased to 16.295 with CSR 1.954 and 19.147 with CSR 2.383 respectively. In August 2016, an advocacy workshop was held resulting the agreement of all stakeholders from each district in South Sulawesi in the development of the cataract blidness control program. Conclusions: By implementing a serious and sustained crash program for cataract blindness control involving stakeholders from each district, the number of cataract blindness in South Sulawesi reduced and the CSR target of 3.000 in 2018 can be reached.
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Testosterone increases corpus cavernous smooth muscle cells in oxidative stress-induced rodents (Sprague-Dawley)
I Nyoman Gede Wardana, IGA Widianti, Gede WirataTestosterone increases corpus cavernous smooth muscle cells in oxidative stress-induced rodents (Sprague-Dawley)
Background: Nowadays, there are many researchers interested in the role of oxidative stress in the pathophysiological mechanism against erectile dysfunction. Oxidative stress occurs when there is an imbalance between pro-oxidant and the ability of the antioxidants to scavenge excess reactive oxygen species. The important role of oxidative stress in the pathophysiological mechanism of male and female infertility has been known. However, its role in maintaining the integrity structure of penile erectile tissue especially corpus cavernous smooth muscle cell has not been investigated comprehensively yet. In another side, testosterone has a critical role in maintaining the integrity of the penile erectile tissue. Aim: This study aims to investigate the effect of oxidative stress condition on the administration of testosterone for increasing corpus cavernous smooth muscle cells. Methods: The experiment uses pretest-posttest control group design. Data were collected from 40 rodent’s strain SD (Sprague-Dawley). Ten penile organs were removed before stress, and 30 rodents given psychosocial stress for 6 weeks. After the third-week of stress, 10 penile organs were removed. At the beginning of the fourth week, 20 rodents were randomly divided into 2 groups: the control group (untreated mouse), were treated with an intramuscular aquabides injection and the case group were treated with intramuscular testosterone injection (case group). Five penile organs from each group were removed to observe the corpus cavernous smooth muscle cells number at the sixth weeks of the stress. During the six week stress, blood samples were collected for MDA and SOD measurement at the beginning, at the third week, and at the sixth week. Results: This study found that oxidative stress decreases the corpus cavernous smooth muscle cell (CCSM) number significantly. The number of CCSM before stress 20,20 ± 1,23, and after the third-week of stress is 14,20 ± 1,03 (P < 0,05). In addition, the administration of testosterone at the beginning of fourth-week of stress raises CCSM number significantly. The number of CCSM before treatment is 13,80 ± 0,84, and after treatment is 18,40 ± 1,14. Conclusion: There was a significant elevation of CCSM number without being affected by oxidative stress in this study.
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Bioequivalence study of dihydroartemisinin-piperaquine (DHP) generic formulation in fixed-dose combination, in healthy Indonesian volunteers
Ani Isnawati, Retno Gitawati, Mariana Raini, Indri Rooslamiati, Lanny Marliany, Effi Setiawati, Vivi SetiawatyBioequivalence study of dihydroartemisinin-piperaquine (DHP) generic formulation in fixed-dose combination, in healthy Indonesian volunteers
Background: Malaria is still considered as a major health problem in the world including in Indonesia, which is regarded as one of the malaria-endemic countries. Since 2006, WHO has recommended the use of artemisinin-based combination therapy (ACT) to treat uncomplicated falciparum malaria. In Indonesia, DHP tablet (combination of dihydroartemisinin and piperaquine) is the first line therapy used in malaria control program, which currently used imported DHP tablet. To produce generic DHP tablet, comparative bioequivalence test between DHP tablet and the drug previously used is needed. Methods: A single dosed, randomized, double-blinded, one-period, and parallel study design was conducted in the present research. Every twenty-four subjects were assigned into two groups, which are test group and comparison group. Results: The results showed that even though in vitro comparison of dissolution test has fulfilled the requirements, in vivo test results has not fulfilled the bioequivalence standards. Obtained geometric mean ratios (90% confidence intervals) of the test drug to comparator drug for dihydroartemisinin were 83.30% (67.06%–103.48%) for AUC0-t, 83.24% (67.10%–103.26%) for AUC0-inf, and 75.67% (61.83%–92.61%) for Cmax. The geometric mean ratios (90% confidence intervals) of the test drug to comparator drug for piperaquine were 97.31% (76.50%–123.80%) for AUC0-t, 94.18% (74.18%–119.59%) for AUC0-inf, and 96.47% (71.80%–129.62%) for Cmax. Conclusions: Therefore, the pharmacokinetic profile of the test drug is concluded to be bio-inequivalent with the comparator drug.
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Agile design of public hospitals in Iran
Ghahraman Mahmoudi, Mohammad Ali Jahani, Masoomeh Abdi, Mousa Yaminfirooz, Mohammad Amin BahramiAgile design of public hospitals in Iran
Background:Hospitals that are part of the organization because of the sensitivity and importance of the treatment must have in today's dynamic agile structure to be able to adapt to environmental changes. Therefore this study was to provide a structural model of agility in hospitals.Methods:This descriptive study was conducted in the year 2015. A total of 260 people were selected as sample from mentioned the statistical population. Validityof the questionnaire through examination exploratory and confirmatory factor analysis and reliability tests with Cronbach's alpha was approved 0.97. Data software 18 SPSS and 8.5 Lisrel a factor analysis using mathematical models the final model was developed based on confirmatory factor analysis confirmed the pattern was evaluated.Results:Question related to four agility (responsiveness, competence, flexibility, speed) are measured at the agility hospital And supply chain (independent variables) to correctly cover the variable and valid. Agile supply chain variable between maximum sensitivity and responsiveness(1.98±0.66) To develop the skills of employees received the lowest average (1.34±0.46) As well as structural equation modeling and all relationships were verified (P-value < 0.001).Conclusions:Therefore, it is suggested to apply that to be successful and better adapted to the environment and achieve enhanced service quality, employee satisfaction and patients, competitiveness, reduce costs, reduce time to service delivery and organizational agility.
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Plasma miR-135a; a potential biomarker for diagnosis of new type 2 diabetes (T2DM)
Mohamad Reza Sarookhani, Maryam Honardoost, Farshad Foroughi, Yousef Khazaei MonfaredPlasma miR-135a; a potential biomarker for diagnosis of new type 2 diabetes (T2DM)
Background: MicroRNAs are a class of negative regulators of gene expression. Evidence indicates that miRNAs involved in the pathogenesis of New type 2 diabetes(NT2D) through decrease the expression of the genes secreting insulin and increase expression of insulin secretion suppressing ones, as well as exocytosis, incorporate in New type 2 diabetes. In this study, we evaluated the expression level of miR-135 in plasma sample of those prone to susceptible diabetes and New type 2 diabetes patients compared to the control group.
Methods: Subsequently to evaluation of biochemical parameters such as (TG, TC, HDL, and LDL) in susceptible diabetes, New type 2 diabetes and control group, miR-135a level was measured by qRT-PCR in the plasma samples and results were analyzed by Stata and REST software.
Results: We identified a significant increase in miR-135a expression in New type 2 diabetes and susceptible diabetes samples compared to the control group. AUC in ROC curve analysis was 1.1 respectively (confidence interval of 1.0-1.0) for NT2D and susceptible diabetes group, the best cut-off points for diagnostics in diabetics and susceptible diabetes were 2.00 and 1.02. The optimum sensitivity and specificity for both groups were 100 and 100. Results confirmed the test for 100% confidence in healthy, susceptible diabetes and New type 2 diabetes subjects.
Conclusion: It seems that plasma level of miR-135a can be a desirable biomarker to differentiate T2DM diabetics from the control group.
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Cranial nerve disorder on nasopharyngeal cancer patient at Dr.Kariadi Hospital Semarang 2014-2016
Dwi Antono, Muyassaroh Muyassaroh, Rully Satriawan, Rachma Purnama SariCranial nerve disorder on nasopharyngeal cancer patient at Dr.Kariadi Hospital Semarang 2014-2016
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Effect of glomerulosclerosis index, tubular index, and matrix metalloprotein against serum creatinine and estimated glomerular filtration rate in obstructive kidney stone patients in Sanglah General Hospital Denpasar-Bali
Oka A. A. G, Sun FuEffect of glomerulosclerosis index, tubular index, and matrix metalloprotein against serum creatinine and estimated glomerular filtration rate in obstructive kidney stone patients in Sanglah General Hospital Denpasar-Bali
Background: Kidney stones is one of the many causes of chronic kidney disease (CKD) in clinical and kidney fibrosis in histopathology presentation. Its occurs characterized by the presence of glomerulosclerosis (GS), tubulointerstitial fibrosis (TIF) and tubular atrophy (TA). This research aims to find out that the effect of glomerulosclerosis index (GSI), tubular index (TI), and matrix metalloprotein (MMP-9) against serum creatinine (SC) and estimated glomerular filtration rate (eGFR) in kidney stone disease. Methode: A total of 62 samples of kidney biopsy patients during kidney stone surgery in Sanglah General Hospital Denpasar-Bali, from February until December 2013. Kidney tissue biopsy stained with Masson's Trichrome. Determination of GSI was counted GS in 30 glomerular in power field 400, and TI was counted normal tubular in 30 glomerular in power field 400, and MMP-9 was carried out using Kit Methode. Structural Equation Modelling (SEM) program Analysis of Moment Structure (AMOS) was used to analyze the effect of GSI, TI, and MMP-9 against SC and eGFR in kidney stone patients. Results: Descriptive analysis were male 43 (69.35%), and female 19 (30.65%). Age (years) 50.0 ± 10.56; SC (mg/dl) 1.71 (0.47 to 6.76); GSI (glomerosclerosis/30 glomerular) 11 (0-30); TI (normal tubulars/30 glomerular) 850.24 (118 to1523); eGFR (ml/min) 65.41 ± 20.47; Leukocytes (cells/mm3) 7.82 ± 1.89; and MMP-9 (ng/ml) 6.13 (0.05 to 28.37). Direct and total effect (direct and indirect effect) were GS to eGFR = -0.16 and 0.33; TI to eLFG = 0.28 and 0.36, GS to SC = 0.31; TI to SC = -0.14; MMP-9 to SC = -0.16; SC to eGFR = -0.55. Conclusion: Direct and total effect of GSI to eGFR were negative (-) 16% and (-) 33%; TI to eGFR were positive (+) 28% and (+) 36%. Direct effect (without indirect effect; direct effect as same as a total effect) of GSI, MMP-9, and TI to SC were positive (+) 31%, negative (-) 16%; and negative (-) 14% consecutively. Direct effect or total effect of SC to eGFR were negative (-) 55%. The results concluded that the effect measurements of urinary MMP-9, and GSI, and TI score to SC were negative (-) 16 %, positive (+) 31 % and negative (-) 14 % consecutively. The effect measurements of urinary MMP-9, and GSI, and TI score to eGFR were negative (-) 0.09 %, negative (-) 16 %, and positive (+) 28 %.
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Correlation between Quality of Work Life (QWL) with Nurse productivity in inpatient room Bhayangkara Tk III Hospital Manado
Natalia G Wara, Starry H Rampengan, Martha KorompisCorrelation between Quality of Work Life (QWL) with Nurse productivity in inpatient room Bhayangkara Tk III Hospital Manado
Background: Productivity is a universal concept that applies to all systems because every activity requires productivity in its implementation. Individual productivity can be assessed from what the individual does in his work. Based on this fact, the purpose of this study is to know the relationship between quality of work life (employee involvement, career development, pride of institution, balanced compensation, job security, available facilities, work environment safety, problem solving and communication) with Work Productivity on Nurse profession at Inpatient Room Bhayangkara TK III Manado Hospital.
Methods: Study design using cross-sectional analytic approach which was conducted in July - December 2017 at Bhayangkara TK III Manado Hospital. Total sampling technique was used by considering inclusion criteria nurses who work> 3 months, and exclusion criteria are nurses who are taking furlough time. The analysis used chi-square test and started from univariate, bivariate and multivariate.
Results: The results showed that the p-value of employee involvement (0.089), career development (0.006), pride of institutions (0.060), balanced compensation (0.005), available facilities (0.014), occupational security (0.388) work safety (0.003), problem-solving (0.006), communication (0.009) with work productivity of inpatient nurses at Bhayangkara Tk III Manado Hospital.
Conclusions: There is a relationship between career development, balanced compensation, available facilities, work environment safety, communication and problem solving are the variables most related to work productivity of inpatient nurses at Bhayangkara TK III Manado Hospital.
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Higher endometrial receptivity caused by Letrozole in antagonist protocol-stimulated mouse uterus
A. A. N. Anantasika, K. Suwiyoga, I. M. Bakta, I. N. M. AstawaHigher endometrial receptivity caused by Letrozole in antagonist protocol-stimulated mouse uterus
Background: The implantation rate of IVF remains low due to the adverse effect of ovarian stimulation on endometrial receptivity. Integrin β3, E-cadherin and Leukemia Inhibitory Factor (LIF) are the best markers known for endometrial receptivity evaluation. In this study, the effect of adding Letrozole to antagonist protocol based on the expression of integrin β3, E-cadherin and LIF level during implantation window was investigated. Letrozole is an inhibitor of aromatase that can prevent the supraphysiological estrogen level. The goal of the study was to prove that adding Letrozole to IVF antagonist protocol can increase the expression of Integrin β3, E-cadherin, and LIF concentration of mice uterine.
Methods: This is an experimental study with a post-test only group design using Balb/c mice mimicked ovarian stimulated IVF. Antagonist protocol was applied to one group as ovarian stimulation, while the other group received the combination of Letrozole and antagonist protocol. Uterus samples were collected 48 hours after ovarian stimulation. Integrin β3 and E-cadherin expression were detected by immunohistochemistry technique and LIF level assay by ELISA. Normality test was carried out using Shapiro-Wilk, and homogeneity test by Levene’s T. Comparison between integrin β3 and E-cadherin expression were tested by Mann-Whitney and Fisher's exact, while comparison of LIF was tested by Mann- Whitney, with p<0.05 considered as significant. Path analysis was done to measure each variable contribution.
Results: The Letrozole + GnRH antagonist treated mice showed significantly higher integrin β3 (2.71 + 0.61 vs 1.04 + 0.08, p<0.05) and E-cadherin (3.73 + 0.28 vs 1.16 + 0.29, p<0.05) expression in endometrium. It also showed significantly higher level of uterine LIF (1.78 + 0.13 vs 1.66 + 0.17 ng/ml, p<0.05) during implantation window than GnRH antagonist treated mice alone. Expression of integrin β3 (c2= 22.91, p<0.05) and E-cadherin (c2=36.00, p<0.05) were significantly higher in Letrozole group compared to control.
Conclusion: Letrozole caused higher expression of Integrin β3, e-cadherin, and, LIF concentration in Mice uterine stimulated by antagonist protocol. Letrozole had the highest contribution to the increase of E-cadherin. Integrin β3 together with E-cadherin and Letrozole had 31.4% contribution to the increase of LIF.
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Operative Nuances of Endoscopic Third Ventriculostomy for Pediatric Obstructive Hydrocephalus
Dewa Putu Wisnu Wardhana, Sri MaliawanOperative Nuances of Endoscopic Third Ventriculostomy for Pediatric Obstructive Hydrocephalus
Background; High incidence of congenital hydrocephalus will become a big problem for the family, and even the nation. The standard management is liquoral shunnting with implantation of various V-p Shunt devices. The complication relatively high beside high cost. Endoscopic third ventriculostomy(ETV) is considered to be superior to V-P Shunt.
Method: All of the Obtructive hydrocephalus admitted to Sanglah Hospital between 2005 until 2016 who treated by ETV were analyzed the method of how we do it.
Result: The most important is patient selection, than trajectory with rigid endoscope, identify the foramen of Monroe by following choroidal flexus, identify infundibular recess, mammillary body, locate the fenestration of base of the third ventricle safely by monopolar cauther, dilated the fenestration by Fogarty catheter F3/F4, fenestration of Liliquist membrane, and last is closing and suturing the dura and skin water tightly.
Conclusion: ETV is the simple procedure for hydrocephalus lower cost compares to V-p Shunt and high successful rate, and low risk of complication, V-p shunt just for those patients who does not response to ETV.
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The relationship between spiritual intelligence, life expectancy, and self- regulation among high school students
Najaf Tahmasbipour, Sadegh Nasri, Zahra RafieeyazdThe relationship between spiritual intelligence, life expectancy, and self- regulation among high school students
The present study investigated the relationship between spiritual intelligence and life expectancy and self-regulation among students. The study was a descriptive and correlational research. The population included all high school female students in Tehran province. Using Cochran formula, 384 students were selected as the sample through multi-step cluster random sampling. The instruments included King Spiritual Intelligence Questionnaire (2008), Hope Scale Schneider (1991), and Boufard self-regulation questionnaire (1995). The data was analyzed through descriptive and inferential statistics (multivariate regression and canonical correlation). The results showed that there is a positive relationship between the spiritual intelligence and life expectancy and self-regulation. Also, through Canonical analysis, it was showed that spiritual intelligence explained 26% and 2.5% of variance in life expectancy and self-regulation, respectively. Regression analysis of spiritual intelligence components showed that transcendental consciousness, personal meaning generation, and expanded state of consciousness all together explained 17.4 % of variance in life expectancy. Similarly, 18% of the variance in self-regulation was explained by personal meaning generation and expanded state of consciousness. Due to the important role of spiritual intelligence in life expectancy and self-regulation, it is suggested that spiritual intelligence training for students be taken into account.
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The effect of slow-stroke back massage on anxiety in female patients with heart failure
Fatemeh Mohaddes, Narges Ghaderi Ehsanpour, Tahereh Najafi GhezeljehThe effect of slow-stroke back massage on anxiety in female patients with heart failure
Introduction and Aims: Patients with heart failure experience many physical and psychological symptoms such as anxiety, which reduces their life expectancy. The use of alternative methods of therapy, including slow-stroke back massage (SSBM), can be effective in reducing the symptoms of heart failure. This study aims to investigate the effect of slow-stroke back massage on anxiety in women with heart failure.
Methods: In this quasi-experimental study conducted in the Department of Cardiology of Ghaem Hospital (affiliated with the Hamedan University of Medical Sciences) in 2015, 60 patients with heart failure were randomly assigned to the control and intervention groups. Slow-stroke back massage was performed in 7 sessions for 7 consecutive days (one session per day) for 10 minutes in the intervention group. Demographic characteristics and standard anxiety questionnaires Depression, Anxiety and Stress Scales (DASS-42). were used to collect the patient data. The data were analyzed using descriptive and inferential statistics.
Findings: The mean of anxiety before intervention in intervention group 28.2 ±6.04 and in control group was 27.47±5.22 and after the intervention in the intervention group was 21.37±6.24 and in control group 26.1±6.27, that showed a significant difference compared with before the intervention (p<0.001).
he mean anxiety scores of all participants in the intervention group before and after the intervention was very severe, but after the intervention, its mean anxiety scores decreased. Using Paired t-test, the mean anxiety scores of the control group before and after the intervention was not significantly different (P <0.05).
Conclusion: Slow-stroke back massage significantly decreased anxiety in female patients with heart failure.
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Medicine reminder to improve treatment compliance on geriatric patients with diabetic neuropathy at Sanglah Central Hospital, Bali-Indonesia
Ida Ayu Manik Partha Sutema, Made Krisna Adi Jaya, I Made BaktaMedicine reminder to improve treatment compliance on geriatric patients with diabetic neuropathy at Sanglah Central Hospital, Bali-Indonesia
Background: Geriatric patients are elderly patients who have memory impairment problems, which may have an impact on medication adherence. The aim of this study was to evaluate the effect of medicine reminder on the smartphone to increase the adherence of geriatric patients with type 2 diabetes mellitus. Method: This study used the Randomized Control Trial (RCT) method, where the subjects were divided into 2 groups: geriatric patients who were performing diabetic neuropathic pain therapy with the help of the Medicine Reminder (Group of Intervention) and without the aid of Medicine Reminder (Usual Care) Which are randomized using odd-even techniques. Patient therapy compliance is assessed by pill count. Results: Subjects who received medicine reminder intervention had significantly greater adherence than the control group (p <0.05). The RR value obtained is 2.38 with CI95% at intervals of 1.58-3.61. Conclusions: The medicine reminder application can improve geriatric patient therapy adherence with significant diabetic neuropathic pain.
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The rationale of surgical treatment in pediatric spine tuberculosis
Komang Agung IriantoThe rationale of surgical treatment in pediatric spine tuberculosis
Introduction: Extrapulmonary TB in pediatric patient affects the quality of life and must be considered seriously. Early surgical treatment is needed to eradicate infection, preserve the physis, and simultaneously correct the deformity. The aim of this study is to assess the efficacy of conservative treatment compared to early surgical treatment regarding neurological improvement, kyphotic correction, and pain relieve.
Method: This is a retrospective case series. We reviewed 28 pediatric spine tuberculosis in Dr. Soetomo General Hospital Surabaya, Indonesia during year 2010-2012. All patients have received TB drugs and indicated for surgical treatment, yet the 15 patients did not provide parental consent. These were selected as non-surgical group. Thirteen patients obtained surgical treatment including bone graft, w/o instrumentation (surgical group). All clinical data were collected at the time of diagnosis and a year after treatment. The improvement of kyphotic (thoracic segments) was defined as narrowing of post-treatment Cobb’s angle. Conversely, lordotic improvement (cervical or lumbar segments) was defined as widening Cobb’s angle. Improvement of neurological status (Frankel classification) was analyzed using chi-square test. The deformity correction and pain relieved were analyzed using independent-samples t-test. All statistical analyses were conducted by SPSS-23.
Result: VAS improvement was not significant. Frankle classification in the surgical group was significantly better. The kyphotic deformity correction was 0% (n=8) in the non-surgical group and, 57.1% (n=4) in the surgical group. There lordotic deformity correction was 74.1% (n=4) in non-surgical group and 83.3% (n=5) in surgical group. There is a significant difference of the kyphotic deformity correction between both groups. but no significant difference in lordotic correction.
Conclusion: Surgical management showed better outcomes in the degree of correction (stopped and corrected the kyphosis progression), and also in the neurological improvement.
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Effective methods in preventing plagiarism in medical research: A qualitative study at Tabriz University of Medical Sciences-Iran
Nayer Soltany, Mohammadhiwa Abdekhoda, Shafi HabibiEffective methods in preventing plagiarism in medical research: A qualitative study at Tabriz University of Medical Sciences-Iran
Background: The most effective way to manage problems in research, especially plagiarism, is to prevent them from initially occurring. Therefore, comprehensive planning to prevent and reduce plagiarism, or actions to internalize honesty in speech, behavior, and actions, will not only make researches worthwhile but also reduce plagiarism.
Methods: In this qualitative research, eighteen faculty members of Tabriz University of Medical Sciences participated from 2015-2016. Data were collected through a semi-structured interview and analyzed by qualitative content analysis (Mayring method).
Results: Effective factors in the prevention of plagiarism were extracted and presented in 23 subclasses and four themes including policy-making, legislation, an institutionalization of ethics in research, and the application of technology capabilities.
Conclusion: Providing strategic and operational plans to internalize ethics in research and gradual changes in policy making and updating laws and regulations are factors affecting preventive measures. Also, with an increase in information literacy and applying information technology capabilities, it is possible to prevent informed and uninformed plagiarism.
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Association between premature canities and quality of life at Medan, Indonesia 2017
Putri Ashraf, Nelva K Jusuf, Rointan SimanungkalitAssociation between premature canities and quality of life at Medan, Indonesia 2017
Introduction Premature canities is a terminology to describe a premature condition graying of hair before the age of 20 in Caucasians, 25 in Asians, and 30 in Africans, involving complex processes such as genetic, hormonal and environmental factors. Quality of life is generally measured using a validated questionnaire. Body Image Questionnaires (BIQ) is a questionnaire that specifically assesses the impact of self-appearance, especially in the hair appearance, on the individual self-esteem and the influences in life. In clinical practice, measuring the association of premature canities to the quality of life and understanding how a patient's life is affected by premature canities can be helpful in determining the most appropriate and better management for the patients.
Aim: To evaluate the association between premature canities and quality of life
Methods: This is a cross-sectional analytic method, with BIQ to assess the quality of life. Diagnosis of premature canities was made based on clinical examination. This study involving 63 subjects with premature canities and 114 normal subjects. Statistical analysis was done using descriptive method and chi-square test to assess the association between premature canities and quality of life.
Results: There is a significant association between premature canities and quality of life (P<0.05). There is no significant association between age, sex, and severity degree of premature canities with quality of life (P>0.05).
Conclusion: There is a significant association between premature canities and quality of life, but there is no association between age, sex and severity degree of premature canities with quality of life.
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Impacts of endometrioma type and two-different techniques of laparoscopic cystectomyon ovarian reserve by measuring anti-mullerian hormone concentration
Ida Bagus Putra AdnyanaImpacts of endometrioma type and two-different techniques of laparoscopic cystectomyon ovarian reserve by measuring anti-mullerian hormone concentration
Purpose: This study aims to understand the impact of the type of endometrioma and two different laparoscopic cystectomy excision techniques (“stripping” or complete excision vs partial excision) on the ovarian reserve by measuring the anti-mullerian hormone (AMH) levels in patients with endometrioma.
Method: This is an experimental study in the form of “pre test – post test group design”. The subjects were patients with >3 cm endometrioma detected via transvaginal USG which were classified into two different groups, i.e. the “stripping” laparoscopic cystectomy group as control and partial excision laparoscopic cystectomy as a intervention group. Cystectomy techniques were chosen based on “formuted block sampling”. The AMH levels measurements were performed before the operation (pre-test) and post-operation levels were measured at one and three months after the procedures on both groups. The study was conducted in Bali Royal Hospital (BROS), Denpasar, Indonesia, between January 2012 and January 2018. T-independent test was used to analyse the collected data.
Results: No significant difference in the age and length of marriage between the two groups (p>0.05). Unilateral endometrioma had higher concentration of AMH compared to bilateral endometrioma before the laparoscopy (2.09±1.33 vs 1.99±1.25 ng/ml; p=0.768), 1 month after the laparoscopy (1.20±0.59 vs 1.12±0.72 ng/ml; p=0.647), as well as 3 months after the laparoscopy (1.79±0.97 vs 1.44±0.87 ng/ml; p=0.148), but they were not statistically significant (p>0.05). Based on the laparoscopy techniques, AMH concentration in partial excision laparoscopic cystectomy was significantly greater (p<0.05) than in the stripping laparoscopic cystectomy, whether before laparoscopy (1.87±1.23 vs 2.36±1.13; p= 0.119), 1 month after (1.33±0.62 vs 0.98±0.67 ng/ml; p=0.038), as well as 3 months (1.88±0.97 vs 1.29±0.77; p=0.011) after the surgery.
Conclusion: Unilateral and bilateral endometriomas have no significant difference in AMH levels. The partial excision laparoscopic cystectomy had significantly less effect on the AMH level compared with stripping laparoscopic cystectomy.
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Adult Idiopathic Scoliosis: Correction or not?
Tjokorda GB MahadewaAdult Idiopathic Scoliosis: Correction or not?
The authorpresents areviewofadult idiopathic scoliosis (AIS), etiology, epidemiology, clinical and radiology assesment, conservative managementandsurgery,includingthe pitfallsthat are oftenencountered. Although the author's experience in handling AIS is quite new,butgiven thedesiretosharethe difficultiesandobstaclesencourageauthortopublish the review.The authordoes notintendto teachbutto shareandstart doingscoliosissurgeryandshould be studiedproperly.
The success ofsurgeryin these patients,the resultswere encouragingfor bothpatientand doctor. Calculation ofappropriate corrections,outsmartwedgevertebraandhemivertebra, mountingscrewwithanatomybased onlandmarksandstraightenthe curveof the spineisthe mostinterestingpart. Ifallcan bedonewitheitherthepatientcanhave anear normalcurveandis free fromthe difficulty of expandinglungorneurological deficits.
Scoliosiscorrectionshouldalsobe doneby us, theneurosurgeonspine, shouldbe started immediatelyin Indonesia, because the casesarethere,verychallengingandencouraging resultssoworth doing.Thorough knowledgeof the anatomy ofthe spinelandmarksandstrictselection of casesas indicated,wouldmaximize the results ofpatientoutcomes.
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Measuring the nurses’ professional self-concept and its correlation with working stress in Iranian educational Hospitals
Razieh Montazeralfaraj Montazeralfaraj, Elham Ahmadi Ahmadi, Arefeh Dehghani Tafti Tafti, Omid Barati, Mohammad Amin BahramiMeasuring the nurses’ professional self-concept and its correlation with working stress in Iranian educational Hospitals
Introduction: Professional self-concept is defined as an individual’s perception of self as a professional person, which affects different aspects of professional performance. This study was aimed to investigate the professional self-concept and its relation to work stress in a sample of Iranian nurses.
Methods: This research is a cross-sectional study using Cowin's 36-item questionnaire of professional self-concept and the Expanded Nursing Stress Scale (ENSS) in three educational hospitals of Yazd, Iran. A total of 150 nurses were included. We used descriptive statistics and Pearson’s correlation coefficient for data analysis in SPSS 22.
Results: The analysis of gathered data was done separately for included hospitals due to the nature of the study. Only in one hospital, a statistical relationship was found between professional self-concept and nursing stress while in the other two hospitals, the same relationship was not statistically significant. This finding may be due to different working conditions in different types of hospitals.
Conclusion: Although the definitive confirmation of the relationship between professional self-concept and working stress requires further studies, the approved effect of professional self-concept on some aspects of nursing stress in the studied hospitals can have important policy implications.
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The relationship between emotional intelligence with general health and academic achievement: a case study in Iran’s Health system
Mohammad Ranjbar, Razieh Montazerfaraj, Mastoureh PourmahmoodianThe relationship between emotional intelligence with general health and academic achievement: a case study in Iran’s Health system
Objective: Today, emotional intelligence as a new scientific issue, plays an important role in various aspects of individuals life. Studies that have been done in this area, explain the role of emotional intelligence in different aspects of one's life such as academic achievement, general health, and social relations. The aim of this study was to determine the relationship between emotional intelligence, general health and academic achievement among students of Shahid - Sadooghi University of Medical Sciences in Yazd. Methods: Siberia Shirring Emotional Intelligence and Goldberg General Health Questionnaire were used for data collection. Students Average GPA was used as an indicator of academic achievement. To analyze the data, Pearson correlation and regression analysis were used. Results: The results showed that average emotional intelligence and average general health for students are (15.46 ± 99.63) and (11.36 ± 22.98), respectively. There was a significant relationship between emotional intelligence, general health and academic achievement (p<0.001). Other findings showed that there is a statistical correlation between some demographic information with emotional intelligence, general health and academic achievement (p<0.001).
Conclusion: In order to achieve a high level of academic skills, and future success, in addition to general cognitive abilities, students should have suitable growth in aspects such as emotional control. Therefore it is recommended for university curriculum planners to pay more attention to emotional intelligence and the need for improving it among students.
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Cost for traffic accident related injuries and its comparison it with the national standard: A case study in Iran
Somayeh Mahdiyan Mahdiyan, Kavos Asgari Asgari, Mohammad RanjbarCost for traffic accident related injuries and its comparison it with the national standard: A case study in Iran
Introduction: Since the World Health Organization (WHO) has emphasized the importance of estimating the economic costs and traffic-related injuries the society as well as their roles in the analysis of cost efficiency; traffic-related accidents toll estimation has risen as one of the main concerns of the WHO.
Materials and methods: This analytical, descriptive study is an applied research conducted in 2015 in Isfahan province. Among the 35 educational health centers and hospitals in Isfahan, 19 hospitals were selected randomly according to the type of the centers. Information was gathered using traffic accidents system and imported into the Microsoft Excel software. In a country standard, the cost for each patient in traffic accident by NO. 400/11607, dated 9/7/2016 has announced from the Ministry of Health and Medical Education to the Isfahan University of Medical Sciences.
Results: The highest average spending per injured patient is in the Imam Musa Kazim hospital, and lowest average spending per patient can be seen in the hospital Behnia Tiran. (Please elaborate more information in this section)
Discussion and Conclusion: Imam Musa Kazem and Imam Hussein Children’s Teaching Hospital including: the high average of staying patients, type and cost of equipment in Al Zahra educational health treatment center, the consuming prostheses and the utilization of capital equipment such as CT scan machine Multi 64 makes to increase the average cost of a patient in centers compared to other health centers. On the other hand, the cost of accidental outpatients is not registered in the system, so these factors make the average cost of hospitals higher than country standard.Full Article (HTML) | download PDF
Utilization of Medical Education research studies: A survey among participants in Iranian National Conference on Medical Education
Tahereh Changiz, Alireza Yousefy, Mohammad FakhariUtilization of Medical Education research studies: A survey among participants in Iranian National Conference on Medical Education
Introduction: Conferences and scientific meetings are valuable opportunities to transfer and exchange research findings. In Iran, National Conference on Medical Education is held annually, with more than 1500 participants from different disciplines. Participants’ competency in utilizing research findings, research finding readiness for utilization, and perceived organizational support are three domains that contribute to the enhancement of research utilization in medical education. This study was conducted to assess the conference participants’ own competency on research utilization, viewpoints about research readiness and perceived organizational support for research utilization in medical education.
Method: This is a survey study on a convenient sample of participants in the conference; researcher-designed, self-administered questionnaire was applied. It consisted of 19 items in four domains (baseline characteristics, scientific activities, Competency for research report utilization, Research findings readiness for utilization and, organizational support for research utilization).The face and content validity of the questionnaire was approved by experts in the field, and its reliability was 0.94.Data were analyzed by descriptive analysis, Pearson correlation, one way ANOVA and stepwise linear regression tests.
Results: 130 questionnaires were filled (response rate was 52%). 36% had a medical education degree. Faculty members rated their competency in the utilization of research report, viewpoint toward readiness of research report for utilization, and organizational support above the average. There was a statistically significant positive correlation between research utilization competency and the number scientific articles they had written, journal clubs participated and their work experience. The stepwise linear regression test revealed that journal club participation is the main factor of competency in research report utilization predictive model.
Conclusion: Participants’ competency and viewpoint about research utilization were not desirable. The medical education must invest in training researchers and utilizers to earn essential competencies and change their mind about the important role of research findings in decision making. A limited study in this field implies the need to do more studies on research utilization in medical education.
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Evaluating Hospital safety index in Susa public hospital: An action research study
Ahmad Reza Raeisi, Amin Torabipour, Leyla KarimiEvaluating Hospital safety index in Susa public hospital: An action research study
Introduction: The role of the hospital in maintenance and promotion of public health is more important in times of crisis because the hospitals also act as public shelters and a ray of hope for the affected population in the crisis. Therefore, preparation and continuous improvement of the hospital's safety against probable disasters is one of managerial key tasks. The aim of this research was to evaluate hospital safety index in Susa public hospital before and after interventions. Method: This is an action research study which was conducted from July 2015 to July 2016 in Susa public hospital, Khuzestan, Iran. The study was performed using Hospital Safety Index (HSI) checklist of the Iranian National Institute of Health Research (INIHR). The checklist has three main modules and 145 measures. The hospital was categorized based on A, B, and C level of safety. Result: The results showed that hospital safety index in the first year was at level C which after planned managerial interventions was promoted to the level B in the second year. Despite the partial improvement in the overall hospital safety index level in the second year, the safety level of three main modules including functional, structural, and non-structural safety was still at level C in both years. Despite the improvement of the overall hospital safety score in the second year, the safety score in three main modules remained at a level C. Conclusion: Therefore, the hospital's managers should address the hospital safety weaknesses using safety improvement techniques and quality improvement tools.
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The effect of educational Intervention based on Health Belief Model (HBM) on the promotion of teachers social capital in Baft in 2015
Rahmatolah Dadvar, Mohammad Hossein Baghianimoghadam, Seyyed Saeed MazloomiThe effect of educational Intervention based on Health Belief Model (HBM) on the promotion of teachers social capital in Baft in 2015
Background: This study aimed to determine the effect of a training program based on Health Belief Model for the promotion of teachers' social capital in the city of Baft.
Methodology: The present research is an experimental and interventional study. The sample size was 100 school teachers in the city of Baft who were selected randomly from among 500 teachers using Cochran sample size formula and assigned to two groups of 50 experiment and control. The instruction was conducted in 9 two- hour sessions in the form of pamphlets, lectures, and group discussions and the post-test was performed after 3 months. Data collection tools included the author-made 36-item HBM questionnaires and 36-item Bohlen social capital questionnaire. Data analysis methods included correlation coefficients of the regression slope (b), beta values or standardized regression coefficient, T values for each variable, determining their significant levels, and covariance analysis carried out.
Results: Comparison of the pre-test and post-test means among components of the health belief model and social capital of in both experiment and control groups showed that there was no significant difference between the two groups in the pre-test; however, comparison of results in post-test the showed significant difference. Levene test calculation, T, and covariance confirmed these differences and reflected the impact of intervention and implementation of a training program on the experiment group.
Conclusion: According to the results, the impact of training programs implementation to increase levels of social capital was approved.
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The effect of red guava juice (Psidium guajava Linn.) in decreasing uric acid and creatinine levels of white mice (Mus musculus) with hyperuricemia
F. W. Aprillinda, D. Paramasari, W. BrianThe effect of red guava juice (Psidium guajava Linn.) in decreasing uric acid and creatinine levels of white mice (Mus musculus) with hyperuricemia
Latar Belakang: Asam urat adalah produk akhir metabolisme purin pada manusia. Peningkatan produksi asam urat atau penurunan ekskresi asam urat di ginjal dapat mempengaruhi kenaikan kadar kreatinin darah. Jambu biji merah (Psidium Guajava Linn.) merupakan buah tinggi kandungan vitamin C, polifenol, flavonoid yang berfungsi sebagai antioksidan. Secara empiris jambu biji merah digunakan sebagai obat berbagai penyakit salah satunya hiperurisemia.
Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus jambu biji merah (psidium guajava linn.) terhadap kadar asam urat dan kreatinin darah mencit putih (mus musculus) model hiperurisemia.
Metode: Penelitian ini berjenis true experimental dengan rancangan pre test dan post test control group design. Sampel penelitian sebanyak 48 ekor mencit putih jantan galur Balb/c usia 2 bulan. Pengelompokan di bagi menjadi 6 kelompok, yaitu kelompok KN hanya diberi pakan standar, kelompok KP diinduksi potasium oxonate dan diberi pakan standar, kelompok P1 diinduksi potasium oxonate, diberi pakan standar dan obat allopurinol 0,26 mg/Kg BB mencit/hari, kelompok perlakuan (P2,P3,P4) diinduksi potasium oxonate, diberi pakan standar dan jus jambu biji merah dosis 5 mg/Kg BB mencit/hari, 10 mg/Kg BB mencit/hari, 20 mg/Kg BB mencit/hari. Kadar asam urat darah mencit diukur dengan metode enzimatik dengan menggunakan reagen uric acid FS TBHBA dan Kadar kreatinin darah mencit diukur dengan metode jaffe dengan menggunakan reagen Creatinine FS. Data dianalisis menggunakan uji One Way Anova dan perbedaan bermakna bila nilai p < 0,05.
Hasil: Berdasarkan analisis statistik jus jambu biji merah dosis 5 ml/Kg BB mencit/hari, dosis 10 ml/Kg BB mencit/hari dan dosis 20 ml/Kg BB mencit/hari dapat menurunkan kadar asam urat dan kadar kreatinin secara bermakna (p < 0,05). Penurunan kadar asam urat dan kreatinin terbaik dengan jus jambu biji merah dosis 20 ml/Kg BB mencit/hari dengan hasil penurunan signifikansi kadar asam urat (6,71±0,47) dan penurunan signifikansi kadar kreatinin (2,12±0,14).
Kesimpulan: Pemberian jus jambu biji merah dapat menurunkan kadar asam urat dan kreatinin darah mencit. Dosis jus jambu biji merah 20 ml/Kg BB mencit/hari paling efektif dalam menurunkan kadar asam urat dan kreatinin darah mencit putih (mus musculus) model hiperurisemia.
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Association between high survivin expression and late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma
Rosalina Susantio, Mahendra Dewi, Susraini NAssociation between high survivin expression and late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma
Introduction : Nasopharyngeal carcinoma is one of the most common head and neck malignancy in Indonesia. Due to the evaluation of clinical stage is not enough to predict its prognosis, therefore other markers are needed to help to assess its progressivity. One of the markers is known as survivin, an apoptosis inhibitor, which usually shows increase expression in carcinoma. Roles of survivin in nasopharyngeal carcinoma carcinogenesis has not been studied well yet. The aim of this study was to analyze the association between high survivin expression and the late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma.
Methods : This study was a cross-sectional observational analytic study, involved 30 histopathological samples of nasopharyngeal non-keratinizing squamous cell carcinoma, which have been examined at Pathology Anatomy Laboratory Sanglah Hospital by using stratified random sampling from January 2nd, 2014 to May 31st, 2017. The paraffin slides were stained with survivin immunohistochemical at Pathology Anatomy Laboratory Dr. Sardjito Hospital Yogyakarta. The cut-off point of survivin expression was analyzed by Receiver Operator Curve (ROC) analysis. The association between survivin expression and the clinical stage was analyzed with Fisher’s Exact test.
Results : The cut-off point of survivin expression based on ROC analysis was 4.5. High survivin expression was significantly associated with late clinical stage cases (p=0.026; p<0.05).
Conclusion : High survivin expression has a significant association with the late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma. Survivin can be used as a prognostic marker, which is useful for nasopharyngeal carcinoma therapy.
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Sexual function of post-episiotomy mother’s measured using Female Sexual Function Index at Haji Adam Malik Hospital and other networking Hospitals in Medan-Indonesia
Muhammad Wahyu Utomo, M Rhiza Z Tala, Iman Helmi Effendi, Ganis Siregar, Herbert Sihite, Johny MarpaungSexual function of post-episiotomy mother’s measured using Female Sexual Function Index at Haji Adam Malik Hospital and other networking Hospitals in Medan-Indonesia
Introduction: Post episiotomy mother often experience variable sexual function disturbance, and the outcomes are potentially disadvantaged. Sexual function disturbance can be measured by using female sexual function index (FSFI) questionnaire. To determine the sexual function of post-episiotomy mother measured by using FSFI. Methods: Post episiotomy mother fill the FSFI questionnaire. The study had been done at H. Adam Malik Hospital and networking hospital in October 2014. This is a cross-sectional study, using descriptive method. Chi-square test and Fisher exact were used to analyze the data. Results: From 100 cases, the majority are 19-25 years old (43%), 26-30 years old (25%), 31-35 years old (23%), and 36-40 years old (9%). Based on the period of episiotomy, the study objects >9 months ago (65%), 6-9 months ago (14%), and 3-5 months ago (11%). Average scoring of the FFSI domain is lubrication (FSFI score=10.24±3.83), arousal (FSFI score=9.61±3.54), pain (FSFI score=8.91±4.39), satisfaction (FSFI score=8.74±3.66), orgasm (FSFI score=8.63±3.66), and desire (FSFI score=4.72±1.86). The above of cut off point was 26,55 (68%) and below it was (32%). Conclusion: The average score of FSFI based on domain respectively started from the highest to the lowest score are lubrication, arousal, pain, satisfaction, orgasm, and desire. It is important for a woman to understand that sexual dysfunction they experienced after episiotomy is temporary.
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The addition of dates palm (Phoenix dactylifera) on iron supplementation (Fe) increases the hemoglobin level of adolescent girls with anemia
Arum Sari, Eti Poncorini Pamungkasari, Yulia Lanti Retno DewiThe addition of dates palm (Phoenix dactylifera) on iron supplementation (Fe) increases the hemoglobin level of adolescent girls with anemia
Background: Young women have a tenfold anemia risk compared with young men, anemia that occurs in adolescent girls because it has hemoglobin levels less than the normal rate of 12 g / dL. Factors that cause anemia in adolescent girls are the iron deficiency (Fe) due to menstruation, lack of nutrient intakes such as Fe, fat, protein, carbohydrate and energy. In order for adolescents are not lack iron that the body needs, it is a necessary intake of Fe supplementation and also the provision of dates fruit.
Aim: The purpose of this study was to determine the effect of the addition of dates on supplementation of Fe to hemoglobin levels in adolescent girls.
Method: Type of experimental research with the design of Pre Test and Post Test Control Group Design. The sample in this research is adolescent girls with anemia in two Senior High School amounted to 68 people who are divided into two groups that is intervention group counted 32 people and control group counted 36 people. Data collection techniques on Hb measurements with cyanmethemoglobin. The data analysis tools used are paired simple t-test and independent t-test.
Result: There was a significant difference in hemoglobin levels before and after the addition of dates in iron supplementation in adolescent girls with anemia with mean before intervention (9.94 g / dL) and mean after intervention (11.22 g / dL). There were significant differences in hemoglobin levels before and after iron supplementation in adolescent girls with anemia with mean before treatment (10.09 g / dL) and mean after treatment (10.93 g / dL). There was no significant difference in hemoglobin levels after treatment between the intervention groups (addition of dates on Fe supplementation) and control group (Fe supplementation) in adolescent girls with anemia (p = 0.855).
Conclusion: There is a difference of Hb levels between adolescent girls with anemia who were given additional dates in Fe supplementation with only Fe supplementation.
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Improving the quality of positioning and reducing the rotation factor during pediatric portable chest radiography using infant immobilizer
Alireza Mahmoudabadi, Majid Sadeghi Moghadam, Moosa Sajjadi, Majid Shams, Leila AmeriImproving the quality of positioning and reducing the rotation factor during pediatric portable chest radiography using infant immobilizer
Background: The portable chest X-ray in infants hospitalized in neonatal intensive care units is one of the most common diagnostic procedures. Every child during hospitalization period may be incurred over a number of portable chest radiography examinations. Optimization of the infant position for radiography results in the improved diagnostic quality of radiographs.
Objective: To evaluate rotation factor during pediatric portable chest radiography; the present study examined the effect of two different methods to stabilize infant position during radiography on the incidence of rotation.
Materials and methods: This is an interventional study with nonequivalent groups in which rotation factor was evaluated on 250 portable chest radiography on fields of newborns admitted to NICUs (in two intervention and control groups), by comparing the length of posterior ribs on both sides of the chest. In this study, 176 radiographs were related to infants from three university hospitals so that sandbags or patients accompany had been used to stabilize the position of the patient, and 74 radiographs were for infants referred to an academic center whose positions had been stabilized during X-ray using body immobilizer.
Results: The mean difference between the length of right and left posterior ribs in infants stabilized with the usual method (sandbags or patients accompanies) was obtained 6.51±5.05 mm. This statistical index for the second group of infants whose positions had been stabilized through body immobilizer was 2.87±2.15mm. Independent t-test showed a significant difference between the two groups in terms of the difference in the quantity of rotation. In this study, the difference in the length of posterior ribs over 5 mm was found as detectable rotation in the images.
Conclusion: The infant position during radiography can be improved considerably by using proper body immobilizer, and repeating the tests can be avoided due to the inappropriate position. By means of such an instrument, there is no need for the help of accompanies or personnel to stabilize infant position, and their exposure will be prevented.
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Clinical, radiological features, and surgical management of spontaneous intracerebral hemorrhage patients in East Nusa Tenggara-Indonesia
Yustinus Robby Budiman Gondowardojo, Donny Argie, Achmad Adam, Ni Luh Made Novi RatnasariClinical, radiological features, and surgical management of spontaneous intracerebral hemorrhage patients in East Nusa Tenggara-Indonesia
Introduction: Spontaneous intracerebral hemorrhage accounts for 10-15% of strokes and the most fatal type. Management of spontaneous intracerebral hematoma (SICH) is divided into two groups - medical and surgical interventions. Although surgical management is controversial, it can be lifesaving when patient is deteriorating. Objective: The aim of this study are to describe clinical, radiological features, surgical management, and patient’s outcome. Method: This is a descriptive case series study, carried out retrospectively over a period of 2 years at department of surgery, neurosurgery division, Prof. DR. WZ Johannes General Hospital, Kupang. Total of 14 patients were included in the study. Clinical, radiological features, period between onset and operation, surgical management and outcome were identified. Results: Hemiparesis or hemiplegia and language dysfunction (92.86%) was the commonest presenting clinical feature followed by headache (71.43%). Most of the hematomas were in basal ganglia region (57.14%), (50.00%) involving cortex cerebral, (35.71%) involving thalamus, and (28.57%) had intraventricular extension. Craniotomy clot evacuation was the major surgical intervention used to manage. Conclusion: Hemiparesis and language dysfunction were the most frequent presenting clinical features. Deeper region of the brain as basal ganglia more involved than other area of the brain. Surgical intervention used to manage is based on clinical condition and anatomical complication of the patients.
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Restoration of erythrocyte microrheological peculiarities in 5-6-year-old children with scoliosis after daily usage of medioprophylactic clothes for six months
AA Bikbulatova, E.G. Andreeva, I.N MedvedevRestoration of erythrocyte microrheological peculiarities in 5-6-year-old children with scoliosis after daily usage of medioprophylactic clothes for six months
Introduction
Efficient correction methods should be applied early at the detection of scoliosis. One of them is medioprophylactic clothes. However, the effect of medioprophylactic clothes towards the dynamics of erythrocyte microrheological features in children with scoliosis has not been fully studied.
Methods
In this study, we tracked indices changes of erythrocyte cytoarchitecture and aggregation in thirty-nine 5-6-year-old children with grade I-II scoliosis who wore medioprophylactic clothes (designed by one of the authors) daily for 6 months. Thirty-four healthy subjects were enrolled for the control group. The measurement was conducted at the beginning of the research and after 3 and 6 months of intervention.
Result
At their initial state of the observation, the experimental group had worse erythrocyte microrheological features because of physical development inhibition. Daily usage of medioprophylactic clothes for six months reduced the evidence of spinal curvature, increased force, and tolerance of body muscles, lowered reversible and irreversible modified erythrocyte, and weakened spontaneous erythrocyte aggregation.
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Diagnostics of erythrocytes' early microrheological abnormalities in rats with experimentally developed obesity
Svetlana Zavalishina et al., Vatnikov Yu.A, Kubatbekov T.S, Kulikov E.V, Nikishov A.A, Drukovsky S.G, Khomenets N.G, Zaykova E.Yu, Aleshin M.V, Dinchenko O.I, Glagoleva T.IDiagnostics of erythrocytes' early microrheological abnormalities in rats with experimentally developed obesity
Background: Difficulties of the earliest stages' detection of erythrocytes' microrheological abnormalities' development at obesity are connected with falling out of clinicians' field of view of persons with first signs of this pathology. It dictates the necessity of experimental investigations' fulfillment on laboratory animals with just developed obesity in them.
Methods: 91 of healthy male-rats of Vistar line at the age of 2.5-3 months were taken into an investigation. 29 animals of them had experienced no impacts and composed the control group. In 62 rats after their putting into small cages (one specimen - in a cage) during 30 days there was developed OB as the result of giving them of high-caloric diet from combined feed (47%), sweet condensed milk (44%), vegetable oil (8%) and vegetable starch (1%). There were used biochemical, hematological and statistical methods of investigation. During obesity development lipids' peroxidation activated in rats' erythrocytes because of activity weakening of their antioxidant protection.
Results: At obesity development in rats, there was found reliable decrease of erythrocytes-discocytes quantity in blood. It was accompanied by the increase of reversibly and irreversibly changed erythrocytes' quantity in examined animals' blood. At obesity development in rats, there was found the quick rise of erythrocytes' sum in aggregate and these aggregates' quantity at lowering of free erythrocytes' number.
Conclusion: During experimental obesity modeling we noticed very early in rats' blood decrease of erythrocytes-discocytes' quantity, the level rise of their reversibly and irreversibly varieties with the strengthening of their aggregative ability. It takes place in the background of a weakening of erythrocytes' antioxidant protection and activation of lipids' peroxidation in them.
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Hemolytic anemia incident in leprosy patients receiving multi-drug therapy at Haji Adam Malik Central Hospital, Medan-Indonesia.
Wan Tisya Muhaira, Mila Darmi, Ramona Dumasari LubisHemolytic anemia incident in leprosy patients receiving multi-drug therapy at Haji Adam Malik Central Hospital, Medan-Indonesia.
Introduction: Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae ,which is an obligate intracellular bacteria. The therapy of leprosy involves a combination of drugs called multi-drug therapy and one of the drugs included in this therapy is dapsone. Dapsone has a hematotoxic effect because of its toxic metabolite called hydroxilamine. The most common side effect of this drug is hemolytic anemia. Hemolytic anemia occurs when the production of erythrocytes is not balanced with their destruction, causing the lifespan of erythrocyte to become shorter and the bone marrow fails to compensate for this.
Methods: This research is a pre experimental study with a pre-post design, involving 15 leprosy patients that were diagnosed by clinical and laboratory examination. We conducted measurements of hemoglobin, MCV, MCHC, and reticulocyte count before and after the MDT therapy for 3 months.
Results: In this study, the incidence of hemolytic anemia after 3 months receiving MDT was 66.7%. There was decreased hemoglobin level (mean 11.320 g/dl), increased reticulocyte count (mean 2.341%), normal level of MCV (mean 88.807 fL), and decreased level of MCHC (mean 31.920 g%). There were significant differences in hemoglobin level, MCHC level, and reticulocyte count before and after 3 moths of MDT.
Conclusion: There was a significant difference in the number of hemolytic anemia before and after MDT with a p-value < 0.05.
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Radiodermatitis incidents in cancer patients receiving radiotherapy at Haji Adam Malik Central Hospital, Medan-Indonesia
Monalisa Manik, Ariyati Yosi, Chairiyah TanjungRadiodermatitis incidents in cancer patients receiving radiotherapy at Haji Adam Malik Central Hospital, Medan-Indonesia
Introduction: Radiodermatitis or radiation dermatitis is a side effect that is produced in the skin and skin adnexal as a consequence of exposure to radiotherapy. There are several factors that influence the occurrence of radiodermatitis: factors related to the patient (intrinsic), such as: age, race, comorbid conditions, nutritional status and factors associated with treatment (extrinsic), such as: dose radiotherapy, fractionation and radiotherapy techniques.
Methods and results : This study is a descriptive observational study with prospective approach in 50 patients who received radiotherapy in Haji Adam Malik Hospital in Medan. History taking by anamneses and dermatological examinations were conducted to all subjects on the first day, 3 weeks and 8 weeks during radiotherapy. From this study, the majority of the patients are women, age 40-60 years old. The most clinical features is erythema macular rash (100%) and the most location is in the coli region. The majority of total dose is 5000-5900 cGy, and the most fractionation used 31-40 fraction.
Conclusion: The results of this study indicate that elderly, high total dose and fractionation leads to an increased risk of radiodermatitis.
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Dermatophytes and bacterial superinfectives in tinea pedis patients at Haji Adam Malik Central Hospital, Medan-Indonesia
E. Heriawati Sitepu, Kamaliah Muis, Imam Budi PutraDermatophytes and bacterial superinfectives in tinea pedis patients at Haji Adam Malik Central Hospital, Medan-Indonesia
Background: Tinea pedis is a dermatophyte infection of the feet, especially the toes and soles of the feet. The clinical features of tinea pedis consists of four forms. They are interdigitalis, chronic hyperkeratotic, vesicobullous, acute ulcerative or combination. Tinea pedis mainly interdigitalis form often involved bacterial superinfection, initially Gram-positive bacteria, but Gram-negative bacteria may also be involved. In a state of severe infection, the fungus is getting hard to find, otherwise the bacteria were easier to find, so it is necessary to do fungal and bacterial culture with antibiotic sensitivity tests.
Objective: To determine dermatophyte species and bacterial superinfection in tinea pedis at H.Adam Malik General Hospital Medan.
Methods: This study is a descriptive observational with cross sectional design. The results of the study are presented in the form of frequency distribution table. These research involved 45 subjects with tinea pedis who met the inclusion and exclusion criteria. We conducted anamnesis, dermatologic examination and collection of samples that were skin scrapings and smears on the lesion. The samples then examined on microscopic directly by using KOH. When KOH result was positive, it followed by fungal and bacterial culture.
Results: The number of subjects who suffer from tinea pedis is not much different between men (48.9%) and women (51.1%).The highest prevalence was in age group 37-46 years (28,9%), mostly graduated from elementary school (40%) and mostly housekeepers (22.5%), with the most prevalence type was interdigitale by 40 cases (88.9%). Dermatophytes T. mentagrophytes were most found by 44.4%, followed by T. rubrum, E. floccosum and T. violaceum. Bacterial superinfection were mostly involved S.aureus by 30,8%, but B. subtilis, S.epidermidis, K.oxytoca, K.pneumoniae, E. coli, P. vulgaris were also found.
Conclusion: Dermatophytes T. mentagrophytes were most found followed by T. rubrum. Bacterial superinfection S.aureus were mostly involved.
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Ultrasound findings in knee osteoarthritis and rheumatoid arthritis compared to MRI
Hamidreza Sadeghian, Babak Shekarchi, Mohsen Zahedi Niya, Hamed BagheriUltrasound findings in knee osteoarthritis and rheumatoid arthritis compared to MRI
Background: Osteoarthritis is a common musculoskeletal degenerative disease of the cartilage of joints and rheumatoid arthritis is a destructive autoimmune joint disease. The aim of our study was comparing of ultrasound findings in knee osteoarthritis and rheumatoid arthritis with MRI as the gold standard.
Methods: One hundred subjects with chronic knee pain referred for knee MRI were evaluated by ultrasound and MRI on the same day. Two radiologists assessed knee osteoarthritis and rheumatoid arthritis parameters on ultrasound and MRI separately and independently. Agreement between the ultrasound and MRI evaluations was determined using weighted kappa statistics. Intra-class correlation coefficients were used to evaluate agreement using the absolute values of knee osteoarthritis and rheumatoid arthritis parameters.
Results: The overall agreements between the two expert’s radiologists were 85% for the knee joint. Taking an agreement in US examination of 2 expert’s radiologist the overall k for was 0.69 when comparing assessment of knee osteoarthritis and rheumatoid arthritis parameters between ultrasound and MRI. For the knee joint the overall agreement of US findings with MRI was 89%. The overall sensitivity for US of the knee joint was 95.59%, the overall specificity 81.88% in the detection of knee osteoarthritis and rheumatoid arthritis parameters.
Conclusions: Ultrasound assessment of knee osteoarthritis and rheumatoid arthritis parameters is reliable and, showing good diagnostic performance for the detection of knee osteoarthritis and rheumatoid arthritis parameters compared with MRI.
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Effects of jogging and breakfast consumption on weight changes in overweight high school students at Surakarta-Indonesia
Alifiyanti Muharramah, Muchsin Doewes, Didik Gunawan TamtomoEffects of jogging and breakfast consumption on weight changes in overweight high school students at Surakarta-Indonesia
Background: Overweight is a disproportionate nutritional status between intake and energy expenditure that leading such health problems. Its features that arise in adolescence tend to continue in adults and the elderly. Nutritional status in adolescents can indicate the level of dietary issues occur – namely daily intake problems in adolescents in which one of them can be described from breakfast consumption. Fulfillment of intake in those students can affect weight, but other things that need to be considered is about their physical activities such as jogging. Jogging itself is included in cardio exercises (cardiovascular) or often called aerobic exercise. The great benefit of cardio in addition to improving fitness is to increase fat burning in the process of weight loss. Aim: The study aims to evaluate the effects of jogging and breakfast consumption on the alternation of weight in overweight students. Methods: This research is a kind of analytical quasi-experimental design with pre-test and post-test control group design. This study was conducted by grouping it into the treatment group and the control group for 12 weeks. The statistical test uses independent samples t-test to compare the average of either jogging and breakfast consumption influenced the weight changes. Results: The research shows that the body weight changes on the students before and after treatment were differed significantly (p= 0,023). Conclusion: There is a difference in the effect of breakfast consumption compared to the setting of breakfast consumption by jogging against weight changes in overweight adolescents.
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Urological complications following obstetric-gynecologic procedures at Sanglah General Hospital, Bali-Indonesia
Kadek Budi Santosa, Pande Made Wisnu Tirtayasa, Anak Agung Gede OkaUrological complications following obstetric-gynecologic procedures at Sanglah General Hospital, Bali-Indonesia
Background: Surgical complications are often inevitable despite advances and improvement in surgical skills and science. Objective: We performed a study to investigate the clinical features of urological injury following obstetric and gynecologic procedures. Methods: We identified the urological complications which arose during or following obstetric-gynecologic procedures at Sanglah General Hospital, Bali from January 2014 to July 2017. The retrospective data retrieved included details of the procedures, the sites of injury, the treatments, and the outcomes. Results: We had 41 patients with urologic complications following obstetric and gynecologic procedures. According to the medical records, 14 had a bladder injury, 6 had a ureteral injury, 3 had both bladder and ureteral injuries, 16 had a vesicovaginal fistula, and 2 had a ureterovaginal fistula. A total abdominal hysterectomy was the most common procedure underlying complications. The second most common was radical abdominal hysterectomy. All cases of bladder injury underwent a primary suturing during surgery without complications. Where the ureter was injured, 2 patients underwent primary suturing, 5 underwent Boari flap technique, 2 underwent end-to-end anastomosis, and 2 underwent laparoscopic ureteroneocystostomy. Vesicovaginal fistula (VVF) was mostly managed using the transvaginal approach with a tissue flap. The overall success rate of VVF repair was 75% after a primary repair. Conclusion: Bladder injuries were the most common urological injury during obstetric and gynecologic procedures. VVF management with various surgery techniques yields a good result.
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Sequential (Sepsis-Related) Organ Failure Assessment (SOFA) as a predictor of mortality and its correlation with capillary lactate levels in sepsis patients
Made Susila Utama, Candra Lasmono, Tuti Parwati MeratiSequential (Sepsis-Related) Organ Failure Assessment (SOFA) as a predictor of mortality and its correlation with capillary lactate levels in sepsis patients
Background. Sepsis is a life-threatening organ dysfunction, caused by the dysregulation of the body's response to infection. Sepsis remains one of the major causes of hospitalization and mortality in hospitals with large medical expenses. Sequential (sepsis-related) organ failure assessment/SOFA is a score that describes the presence of organ dysfunctions. Lactate is a metabolite formed anaerobic respiration due to hypoperfusion. This study was conducted to determine the role of SOFA score as a predictor of sepsis mortality and its association with capillary lactate levels.
Method. This was an observational study with a cohort design. A sample of 68 subjects with sepsis was taken using consecutive sampling. Calculation of the SOFA score was performed at the beginning of sepsis diagnosis whilst capillary lactate examination was performed in the first 3 hours after diagnosis.
Result. The most frequent cases of organ dysfunction based on SOFA score was respiration system (83.8%), kidney (58.8%), central nervous system (55.9%), cardiovascular (41.2%), coagulation (36.8%), hepatobiliary (23.5%). The mean score of SOFA and the initial capillary lactate level of the living group compared with the deceased group was 4.89±2.06 vs. 7.64±2.67 (p <0.05); 3.28±1.39 vs 3.60±1.43 (p 0.116). The best cut-off values of the SOFA score for mortality were ≥ 5.5 (area under curve/AUC 0.788, sensitivity 74.2% and specificity 62.2%, positive predictive value/PPV 62.2%, and negative predictive value/NPV 74.2%). The log-rank test of the Kaplan-Meier curve was statistically significant (p <0.05). Multivariate Cox regression analysis showed that the SOFA score with cut-off ≥5.5 could be used as a predictor of mortality in sepsis patients with a hazard ratio of 2.475 (p <0.05). Spearman correlation test between SOFA score with initial capillary lactate level was statistically significant (p <0.05) with correlation coefficient 0.319 (weak correlation)
Conclusion. The SOFA score with cut-off ≥5.5 can be used as a predictor of mortality in sepsis. The SOFA score correlated weakly with capillary lactate levels.
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miRNA-124 Loaded Chitosan as Novel Therapy to Induce Neuroprotective and Neurogenesis for Improving Brain Revitalization after Ischemic Stroke
Rataya Paramitha Maliawan, Sieny Veronica, Ni Putu Ayu Pande Arista Dewi, Putu Wisnu Arya Wardana, Dewa Putu Wisnu Wardhana, Sri MaliawanmiRNA-124 Loaded Chitosan as Novel Therapy to Induce Neuroprotective and Neurogenesis for Improving Brain Revitalization after Ischemic Stroke
Stroke is a world leading cause of death and disability in the field of neurology. Ischemic stroke occurs from the obstruction of blood flow to the brain and accounts for 85% of all strokes. Currently, the initial management of stroke to reduce the mortality rate is well known, resulted in increasing number of stroke survivor over the years. However, lack of appropriate treatment for post-stroke recovery lead to prolonged disability that will produce a negative impact, in particular for the productive-aged survivor. Researchers found that miRNA-124 has a lot of beneficial effect to the ischemic brain. miRNA-124 will upregulate the growth factor substances and down-regulate the TNF-α and other cytotoxic substances and increase the number of M2 microglia which is important to promote angiogenesis and matrix remodeling. Expression of miRNA-124 will also lead to differentiation and migration of neuro-progenitor cells to the lesion site while reducing the formation of the glial scar. Furthermore, chitosan derived from the extraction of shells, shrimp, and crabs, have been reported for its various advantages such as anti-infection, anti-tumor and also as carrier-mediated transported across blood–brain barrier. Administration of miRNA-124 loaded chitosan by intranasal route will improve the drug delivery into neuron by provides moiety for cell penetration and as affinity agent towards neuronal tissues. Based on those points, the combination of chitosan and miRNA-124 may be a potential therapy to improve revitalization and reduce disability after stroke ischemic.
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Serum markers of Inflammatory Bowel Disease: A literature review
Siti Muchayat PurnamaningsihSerum markers of Inflammatory Bowel Disease: A literature review
Background: The diagnosis, prognosis, assessment of disease activity and severity, as well as the outcome of therapy of inflammatory bowel disease (IBD), Crohn’s disease (CD), and ulcerative colitis (UC), remain a challenge for physicians treating this disorder. For each of these aspects, there is no single gold standard test or examination. Endoscopy accompanied by histology examination can confirm the diagnosis of IBD. Laboratory markers have been investigated in IBD for diagnostic and differential diagnostic purposes, assessment of disease activity and risk of complications, prediction of relapse, and for monitoring the effect of therapy. Objective: This article provides a review of the literature regarding IBD with the recommendation of prominent markers that can be used for diagnosing and monitoring the disease. Conclusion: C-reactive protein is an acute phase reactant which is best used to assess inflammation in IBD. Fecal calprotectin and lactoferrin are reliable fecal markers to monitor disease activity. The combination of serological marker P-ANCA and ASCA can be used to diagnose CD. In clinical practice, Crohn's Disease Activity Index (CDAI) is used as the primary tool for evaluating IBD.
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Reconstruction of a severe open distal humerus fracture and intercondylar fracture with complete loss of 13 cm humeral bone by using a free vascularized fibular graft: A case report
Kadek Yuris Wira Artha, AA Gede Yuda AsmaraReconstruction of a severe open distal humerus fracture and intercondylar fracture with complete loss of 13 cm humeral bone by using a free vascularized fibular graft: A case report
Background: Segmental bone defects resulting from traumatic injuries are complicated problems with significant long-term morbidity. Vascularized bone grafts, by definition, are placed with their vascularity intact, and thus are immediately viable.
Case: A 46 years old man referred to Sanglah Hospital after roadway accident and subsequently fell to the valley. Open wound Ø 5x2 cm (already stitched), bone loss 13 cm length, tenderness over the arm and elbow, radial artery and ulnar artery palpable, O2 saturation 98%, no paresthesia, no active ROM elbow flexion and extension, active ROM wrist 80/70 , active ROM MCP-IP 90/45, and patient can do a thumb extension. Already done the free vascularized fibular graft, and stabilized with 3.5 mm reconstruction plate and screwing for intercondylar fracture. Then checked with angiography for vascular viability.
Discussion: Management of bone defects after severe open fractures of the distal humerus encompasses many technical difficulties. In these cases, appropriate osteosynthesis may not always feasible, and bone grafting should be considered for the restoration of normal elbow anatomy. Vascularized bone transfers are more efficient than conventional corticocancellous interposition grafting for the management of massive bone loss (>6 cm). The free osteocutaneous fibula flap is a composite tissue transfer suitable to address combined defects. Clinical monitoring and early detection of anastomoses failure can be done within hours after the surgery by evaluating the skin paddle viability.
Conclusion: The surgeon should decide elbow reconstruction in severe injuries that compromise several structures and create tissue defects by careful evaluation. The kind of lesion and mechanism of trauma are not necessarily the most important factors for planning treatment. The free osteocutaneous fibular graft should be further considered as a reconstructive option for the treatment of metaphyseal or juxta-articular complex defects of the elbow joint.
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Hyperbaric oxygen effects towards SIRT1 level in Sprague dawley with endothelial dysfunction by high-cholesterol diet
Herin Setianingsih, Soetjipto Soetjipto, I Ketut Sudiana, M Guritno SuryokusumoHyperbaric oxygen effects towards SIRT1 level in Sprague dawley with endothelial dysfunction by high-cholesterol diet
Introduction: Endothelial dysfunction is an early risk factor for cardiovascular disease and hypertension. Mechanisms that participate in endothelial dysfunction include the decrease of nitric oxide (NO) and the increase of endothelin-1 (ET-1). ATP-sensitive potassium channels (KATP channels) also participate in endothelial cells in the vascular system. This study aims to investigate whether energy / ATP / SIRT1 is involved in endothelial dysfunction after the administration of hyperbaric oxygen (HBO).
Methods: This study was an experimental study, using a randomized post test only control group design using thirty white rats (Rattus norvegicus) Sprague dawley strains.There were 3 groups of p1, p2, and p3, and each group consists of 10 rats with the normal control for p1, high cholesterol diet for p2, and high cholesterol diet with hyperbaric oxygen of 2.4 ATA with 98% O2 for 3 sessions with the duration of 30 minutes / session, and air break for 5 minutes between each session for the period of 10 days consecutively for p3. The level of SIRT 1 was tested by using Elisa method. We applied statistical methods of investigation.
Results: The SIRT1 from ELISA results tend to increase after the administration of hyperbaric oxygen (HBO). Decreased of SIRT1 occur at group was given by high-cholesterol diet (p1=0,188±0,017 ng/ml; p2=0,114±0,029 ng/ml; p3=0,252±0,027 ng/ml). Hypercholesterolemia and endothelial dysfunction affect energy metabolism and reduce ATP levels and nicotinamide adenine dinucleotide (SIRT1). HBO therapy increases ATP and nicotinamide adenine dinucleotide levels which affect the increase of silent mating type information regulation two homologs 1, resulting in the optimal endothelial cell function.
Conclusion: Hyperbaric oxygen can significantly affect the endothelial dysfunction due to an high-cholesterol diet, by increasing the levels of Sirtuin-1.
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