Vol 4, No 1 (2015)
P. K. Hota K. J. Singh
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REGIONAL ANESTHESIA CONTINUOUS BRACHIAL PLEXUS BLOCK WITH ULTRASONOGRAPHY GUIDANCE
T. G. A. Senapathi M. Wiryana P. Astawa N. M. Astawa S. Maliawan M. Bakta
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EFFECT OF VIBRATION AND HEAT COMBINATION ON PRIMARY DYSMENORRHEA
M. Hoseini S. R. Gharahtapeh A. Jahazi
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CONGENITAL ANOMALIES AMONG NEWBORNS
U. K. Devassy M. Danasegaran K. S. Sailesh S. Mishra U. K. Reddy N. J. Antony
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THE ROLE OF RECOMBINANT IL-10 ON THE SERUM LEVEL OF TNF-α, ONE HOUR POST TRAUMATIC BRAIN INJURY OF THE WISTAR RAT
W. Adhimarta A. A. Islam S. Maliawan G. S. Lowrence I. Patellongi
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CORRELATION BETWEEN STRUCTURAL RETINAL NERVE FIBRE LAYER THICKNESS AND FUNCTIONAL VISUAL FIELD LOSS IN PRIMARY OPEN ANGLE GLAUCOMA
A. Arun A. Sadhana R. D. Shankar
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XANTHINE OXYDASE INHIBITION OF KOMBUCHA TEA IN HYPERURICEMIA INDUCED WISTAR RAT: decrease of uric acid, malondialdehyde, and 8-hydroxy-2'-deoxyguanosine
I D. M. Sukrama
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EFFECTIVENESS OF DIFFERENT DETERGENT SOLUTIONS AS LARVISIDE FOR AEDESAEGYPTI LARVAE
I. M. Sudarmaja I. K. Swastika
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AQUEOUS EXTRACT OF BALINESE PURPLE SWEET POTATO (IPOMOEA BATATAS L.) PREVENTS OXIDATIVE STRESS AND DECREASES BLOOD INTERLEUKIN-1 IN HYPERCHOLESTEROLEMIC RABBITS
I M. Jawi A. W. Indrayani I W. P. Sutirta-Yasa
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The Role of Multiplex Polymerase Chain Reaction in Detecting Etiological Causes of Bacterial Prostatitis Associated Benign Prostatic Hyperplasia
Bramastha Rosadi Tjokorda GB Mahadewa Gede Wirya K Duarsa
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ORODISPERSIBLE TABLET: A Patient Friendly Dosage Form (a Review)
C. K. Rameesa M. K. Drisya
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Giant Ovarian cyst in Term Pregnancy - A rare case report
Basanta Manjari Hota Radha Rukmini K Prabhakar Gowdar Channa Basavaih
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SPLENIC INFARCTION: an intriguing and important cause of pain abdomen in high altitude
P. K. Hota, K. J. SinghSPLENIC INFARCTION: an intriguing and important cause of pain abdomen in high altitude
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REGIONAL ANESTHESIA CONTINUOUS BRACHIAL PLEXUS BLOCK WITH ULTRASONOGRAPHY GUIDANCE
T. G. A. Senapathi, M. Wiryana, P. Astawa, N. M. Astawa, S. Maliawan, M. BaktaREGIONAL ANESTHESIA CONTINUOUS BRACHIAL PLEXUS BLOCK WITH ULTRASONOGRAPHY GUIDANCE
Background: Regional anesthesia has an anti-inflammatory effect that blockade the C-fiber hence reduced cytokine production and blocked the activity of the sympathetic nerve fibers. Postoperative pain caused primarily by tissue inflammation and activity of the C-fibers in the manner of reduced the production of cytokines, regional anesthesia may limit the inflammatory response after surgery and severity of postoperative pain. Methods: This study is a clinical experimental study with randomized pre and post test control group design. A total of 24 samples were recruited in this study divided into two groups each consisting of 12 samples. The first group was given regional anesthesia method of continuous brachial plexus block with ultrasound guidance and the second group with general anesthesia method. T-test or Mann-Whitney continued multivariate linear regression analysis was performed to analyze the differences in treatment and not because of differences in the initial values with significance level of p<0.05. Results: This study reports that the mean decreased levels of IL-6 postoperatively in 1stgroup is 29.8 lower than in 2ndgroup and it is statistically significant p< 0.05. There was an increase of IL-10 mean levels from preoperative to postoperatively with significance level of p<0.05 in both groups. Declined in the mean levels of PAF postoperatively in 1st group 1.3 lower than 2nd group and it was statistically significant p<0.05. The declined of postoperative VAS in 1st group is 3.1 lower than 2nd group and it is statistically significant p< 0.05, and it also contained the pure effect of PAF levels against value of VAS that any increased 1ng/ml levels of PAF then an increase in the value of 0.18 cm VAS and this was statistically significant p<0.05. Selection of this anesthesia technique in orthopedic antebrachii surgery provides better inflammatory response and improved clinical outcomes.
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EFFECT OF VIBRATION AND HEAT COMBINATION ON PRIMARY DYSMENORRHEA
M. Hoseini, S. R. Gharahtapeh, A. JahaziEFFECT OF VIBRATION AND HEAT COMBINATION ON PRIMARY DYSMENORRHEA
Background: Primary dysmenorrhoea is a common, idiopathic, chronic pelvic pain syndrome, with unknown aetiology which about 50% of women with regular menstrual period suffer. This study was designed to determine the effect of vibration and heat on primary dysmenorrhea. Materials and Methods: In this clinical trial, 75 female students aged 18-22 years old were evaluated for two menstrual cycles. At the first cycle the participants received the routine pain-relief method (synthetic or herbal medicine and traditional remedies). At the second cycle for each participant combined vibration-heat device was applied for ten minutes during menstrual pain. The average of perceived leg pain, lumbar pain and abdominal pain scores at two cycles were determined. The data were analyzed based on Wilcoxon and T tests by using SPSS (v 16.0) for Windows. Results: The average of all perceived pain scores at two cycles were significantly different before pain relief and after both routine methods and using the device (p<0.001). Those were more significantly reduced after using the device in comparison of using routine methods (p<0.001). Conclusion: Since “vibration-heat” is an effective pain relief method, it can be used as a complementary alternative medicine in primary dysmenorrhea reduction.
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CONGENITAL ANOMALIES AMONG NEWBORNS
U. K. Devassy, M. Danasegaran, K. S. Sailesh, S. Mishra, U. K. Reddy, N. J. AntonyCONGENITAL ANOMALIES AMONG NEWBORNS
Background: The present study was undertaken to assess the incidence of congenital anomalies among newborns. The total anomalies were 280 and the highest incidence has been identified in the year 2011, and the incidences were high in the gastrointestinal system. It also reveals that the incidence is higher in low birth weight newborns, and the major incidence has been identified in full term newborns. Results: results of the study can be used to predict future incidence of anomalies and to increase public awareness about congenital anomalies to take preventive measures.
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THE ROLE OF RECOMBINANT IL-10 ON THE SERUM LEVEL OF TNF-α, ONE HOUR POST TRAUMATIC BRAIN INJURY OF THE WISTAR RAT
W. Adhimarta, A. A. Islam, S. Maliawan, G. S. Lowrence, I. PatellongiTHE ROLE OF RECOMBINANT IL-10 ON THE SERUM LEVEL OF TNF-α, ONE HOUR POST TRAUMATIC BRAIN INJURY OF THE WISTAR RAT
Background: Brain injury often occurs not only primary brain injury, but often also occur secondary brain injury. Inflammation is a process that occurs immediately after trauma characterized by activation of the mediator substance. TNF-α is a major cytokinee involved in the inflammatory processes that have adverse effects if the serum level are excessive. There needs to be a balance of the inflammatory process in the brain injury so things that harm does not occur. As anti-inflammatory IL-10 plays an important role in maintaining the balance. The objective of this study is to determine the effect of IL-10 intervention as an anti-inflammatory will decrease the serum level of TNF-α in traumatic brain injury. Material And Method: Experimental Study in the Rattus Wistar rats, post test control group design, male, aged 3-4 months, with body weight (BW) 300-400g, were obtained from the Laboratory Animal Faculty of Medicine, University of Hasanuddin as much as 24 tails, which is the result of breeding. Subjects were divided into four groups, each group of six rats, treated with controlled cortical impact model (Feeney’s weight-drop) of traumatic brain injury. Blood taken with capillary tube in retro-orbita plexus or sinus.This study has approved by ethical clearance for research. Results: Levels of TNF-α group of rats 1 hour post-trauma without administration of recombinant IL-10 (28.58 ± 7.28) pg / mL; was significantly higher (p <0.05) than the levels of TNF-α rats without kraniektomi group (22.06 ± 3.34) pg / mL and group kraniektomi rats without brain injury (23.07 ± 2.51) pg / mL. Levels of TNF-α group of rats 1 hour post-trauma by administration of recombinant IL-10 (23.39 ± 6.30) pg / mL; significantly lower (p <0.05) than the group of rats 1 hour post-trauma without administration of recombinant IL-10; and did not different significantly (p> 0.05) in the group without craniectomy or craniectomy group without head injury. Conclusions: Intervention of recombinant IL-10 decreases levels of TNF-α serum soon after traumatic brain injury in rats.
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CORRELATION BETWEEN STRUCTURAL RETINAL NERVE FIBRE LAYER THICKNESS AND FUNCTIONAL VISUAL FIELD LOSS IN PRIMARY OPEN ANGLE GLAUCOMA
A. Arun, A. Sadhana, R. D. ShankarCORRELATION BETWEEN STRUCTURAL RETINAL NERVE FIBRE LAYER THICKNESS AND FUNCTIONAL VISUAL FIELD LOSS IN PRIMARY OPEN ANGLE GLAUCOMA
Background: Glaucoma is characterized by progressive degeneration of retinal ganglion cells and their axons that leads to nerve fiber layer loss, optic disc cupping, and consecutive glaucomatous visual field changes. Study is done in Department of ophthalmology, S.V.R.R Government General Hospital, S.V.Medical College Tirupati. A total of 52 eyes of 29 patients were included in the study. Mean age of the patients included in the study is 64.14+/- 11.43 years. Majority were male patients (68.96%). Female patients were only 31.04%.
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XANTHINE OXYDASE INHIBITION OF KOMBUCHA TEA IN HYPERURICEMIA INDUCED WISTAR RAT: decrease of uric acid, malondialdehyde, and 8-hydroxy-2'-deoxyguanosine
I D. M. SukramaXANTHINE OXYDASE INHIBITION OF KOMBUCHA TEA IN HYPERURICEMIA INDUCED WISTAR RAT: decrease of uric acid, malondialdehyde, and 8-hydroxy-2'-deoxyguanosine
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EFFECTIVENESS OF DIFFERENT DETERGENT SOLUTIONS AS LARVISIDE FOR AEDESAEGYPTI LARVAE
I. M. Sudarmaja, I. K. SwastikaEFFECTIVENESS OF DIFFERENT DETERGENT SOLUTIONS AS LARVISIDE FOR AEDESAEGYPTI LARVAE
Background: Dengue hemorrhagic fever the spread of which is mediated by Aedesaegypti mosquito that becomes a health problem in Indonesia every year. Some natural and chemical substances had been experimented to combat Aedesaegypti, one of them is detergent solution. This study aims to investigate the effect of several concentrations of detergent to kill Aedesaegypti larvae, and to find out the lethal concentration (LC)50, LC90, and LC95. Method: Randomized posttest only control group design was applied to observe the percentage of Aedesaegypti larvae instar III-IV killed when they contacted to various detergent concentrations within 24 hour of observation. Results: This study result showed that detergent with the concentration of 0.12 g/l; 0.14 g/l; 0.16 g/l; 0.18 g/l; 0.20 g/l; 0.22 g/l and 0.24 g/l respectively showed the killing of Aedesaegypti larvae 37.6%, 42.4%, 74.4%, 85.6%, 89.6%, 95.2% and 100%, respectively. Probit analysis showed that LC50 = 0.14 gram/liter, LC90 = 0.20 g/l and LC95=0.22 g/l.
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AQUEOUS EXTRACT OF BALINESE PURPLE SWEET POTATO (IPOMOEA BATATAS L.) PREVENTS OXIDATIVE STRESS AND DECREASES BLOOD INTERLEUKIN-1 IN HYPERCHOLESTEROLEMIC RABBITS
I M. Jawi, A. W. Indrayani, I W. P. Sutirta-YasaAQUEOUS EXTRACT OF BALINESE PURPLE SWEET POTATO (IPOMOEA BATATAS L.) PREVENTS OXIDATIVE STRESS AND DECREASES BLOOD INTERLEUKIN-1 IN HYPERCHOLESTEROLEMIC RABBITS
Background: Hypercholesterolemia can cause oxidative stress, endothelial dysfunction and atherosclerosis. Anthocyanin can prevent oxidative stress, it will decrease the inflammation by decreasing the pro-inflammatory cytokine in animal models. Purple sweet potato in Bali has been proven of having high anthocyanins content. The aim of these study was to prove the ability of aqueous extract of Balinese purple sweet potato (Ipomoea batatas L.) in decreasing the blood interleukin-1 level in hypercholesterolemic rabbits. Methods: Subjects of this study were 18 male adult rabbits divided into 3 groups with randomized post-test only control group design. Group 1 rabbits were given standard diet as a control group. Group 2 rabbits were given high cholesterol diet. Group 3 rabbits were given aqueous extract of Balinese purple sweet potato 4 ml/Kg.BW/day and high cholesterol diet. After 60 days of treatment, the blood level of total cholesterol, MDA and interleukin-1 were measured as post test examination. The data were analysed by using anova. Results: The results showed significant increases of blood total cholesterol, MDA, and interleukin-1 in group 2 (p<0.05). In group 3 the increases of blood total cholesterol and MDA levels were sligthly lower than the group 2 (p<0.05). Group 3 also showed significantly lower of blood interleukin-1 levels than those in group 2 (p<0.05). Conclusion: From this finding, it can be concluded that aqueous extract of Balinese purple sweet potato can decrease oxidative stress and decrease the level of interleukin-1 in hypercholesterolemic rabbits.
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The Role of Multiplex Polymerase Chain Reaction in Detecting Etiological Causes of Bacterial Prostatitis Associated Benign Prostatic Hyperplasia
Bramastha Rosadi, Tjokorda GB Mahadewa, Gede Wirya K DuarsaThe Role of Multiplex Polymerase Chain Reaction in Detecting Etiological Causes of Bacterial Prostatitis Associated Benign Prostatic Hyperplasia
Background: Benign Prostatic Hyperplasia (BPH) has been correlated with chronic prostatitis according recent study. Chronic pelvic pain is the chief complain of BPH followed by prostatitis. The gold standard of the etiological diagnosis is urine culture, but the negativity rate is still high. Multiplex polymerase chain reaction (PCR) as a diagnostic tool in search of etiological causes could identify microorganism on DNA level. This research aims to find out the role of multiplex polymerase chain reaction as diagnostic tools on prostatitis patients. Material and Method: A total of 12 samples collected during the TURP procedure in Sanglah General Hospital Denpasar – Bali from February until May 2015. All of the samples has been diagnosed prostatitis clinically and perform urine culture test. The prostate specimen taken was sent to the Pathological anatomy for histopathology diagnostic and underwent multiplex PCR for etiologic diagnostic. Result: 12 samples have been declared as prostatitis based on histopathology examination, and then were analyzed using multiplex PCR. 10 samples were positive (6 were E. coli, 2 were C. trachomatis, the rest were N. gonorrhea and P. aeruginosa). The urine culture revealed 9 positive, within the result 6 were E. coli, and the others were P. aeruginosa, M. morganii and A. haemolyticus. Conclusion: In prostatitis patient, the etiological diagnostic was important. Multiplex PCR as diagnostic tools could detect the microorganism on a negative urine culture. The combination of the urine culture test and multiplex PCR revealed a better result on etiologic diagnosis which leads to a better management of the disease.
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ORODISPERSIBLE TABLET: A Patient Friendly Dosage Form (a Review)
C. K. Rameesa, M. K. DrisyaORODISPERSIBLE TABLET: A Patient Friendly Dosage Form (a Review)
Background: The most common and preferred route of drug administration is through the oral route. Orodispersible tablets are gaining importance among novel oral drug delivery system as they have improved patient compliance and have some additional advantages compared to other formulation. They are also solid unit dosage forms, which disintegrate in the mouth within a minute in the presence of saliva due to superdisintegrants in the formulation. Thus this type of drug delivery helps a proper per oral administration in pediatric and geriatric population where swallowing is a matter of trouble. Various scientists have prepared orodispersible tablets by following various methods. However, the most common method is the direct compression method. Other special methods are Freeze Drying,Tablet Molding, Sublimation, Spray Drying, Mass extrusion, Phase transition process, etc. Since these tablets dissolve directly in the mouth, so, their taste is also an important factor. Various approaches have been taken in order to mask the bitter taste of the drug. A number of scientists have explored several drugs in this field. Like all other solid dosage forms, they are also evaluated in the field of hardness, friability, wetting time, moisture uptake, disintegration test and dissolution test.
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Giant Ovarian cyst in Term Pregnancy - A rare case report
Basanta Manjari Hota, Radha Rukmini K, Prabhakar Gowdar Channa BasavaihGiant Ovarian cyst in Term Pregnancy - A rare case report
Ovarian cyst in pregnancy may have a poor feto-maternal outcome. A 25 year old multi gravida, post caesarean pregnancy at term reported with antenatal ultrasonography (USG) diagnosis of giant unilocular ovarian cyst and normal obstetrics findings. Elective lower segment caesarean section (LSCS) with left salpingo-oophorectomy and right partial salpingectomy was done. Left ovarian cyst was 29x20 cm. in size with smooth surface, no adhesion, no free fluid in peritoneal cavity and a normal right ovary. Histopathological examination revealed mucinous cystadenoma of ovary. Post-operative period was uneventful. The rarity of the case and its successful management prompted us for reporting along with review of literatures.
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