ORIGINAL ARTICLE

Association between high survivin expression and late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma

Rosalina Susantio , Mahendra Dewi, Susraini N

Rosalina Susantio
Department of Pathology Anatomy Faculty of Medicine Udayana University/ Sanglah General Hospital Denpasar-Bali. Email: [email protected]

Mahendra Dewi
Department of Pathology Anatomy Faculty of Medicine Udayana University/ Sanglah General Hospital Denpasar-Bali

Susraini N
Department of Pathology Anatomy Faculty of Medicine Udayana University/ Sanglah General Hospital Denpasar-Bali
Online First: August 08, 2018 | Cite this Article
Susantio, R., Dewi, M., N, S. 2018. Association between high survivin expression and late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma. Bali Medical Journal 7(2). DOI:10.15562/bmj.v7i2.969


Introduction : Nasopharyngeal carcinoma is one of the most common head and neck malignancy in Indonesia. Due to the evaluation of clinical stage is not enough to predict its prognosis, therefore other markers are needed to help to assess its progressivity. One of the markers is known as survivin, an apoptosis inhibitor, which usually shows increase expression in carcinoma. Roles of survivin in nasopharyngeal carcinoma carcinogenesis has not been studied well yet. The aim of this study was to analyze the association between high survivin expression and the late clinical stage of nasopharyngeal non-keratinizing squamous cell carcinoma.

Methods : This study was a cross-sectional observational analytic study, involved 30 histopathological samples of nasopharyngeal non-keratinizing squamous cell carcinoma, which have been examined at Pathology Anatomy Laboratory Sanglah Hospital by using stratified random sampling from January 2nd, 2014 to May 31st, 2017. The paraffin slides were stained with survivin immunohistochemical at Pathology Anatomy Laboratory Dr. Sardjito Hospital Yogyakarta. The cut-off point of survivin expression was analyzed by Receiver Operator Curve (ROC) analysis. The association between survivin expression and the clinical stage was analyzed with Fisher’s Exact test.

Results : The cut-off point of survivin expression based on ROC analysis was 4.5. High survivin expression was significantly associated with late clinical stage cases (p=0.026; p<0.05).

Conclusion : High survivin expression has a significant association with the late clinical  stage of nasopharyngeal non-keratinizing squamous cell carcinoma. Survivin can be used as a prognostic marker, which is useful for nasopharyngeal carcinoma therapy.

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