The role of single nucleotide Interleukin-6 (IL-6) polymorphism gene in Psoriasis vulgaris patients at Haji Adam Malik Central Hospital, Medan-Indonesia
Cashtry Meher
Resident in Department of Dermatology and Venereology, Faculty of Medicine, Sumatera Utara University, Medan-Indonesia. Email: [email protected]
Irma . D. Roesyanto-Mahadi
Consultant in Alergy Subdivision, Department of Dermatology and Venereology, Faculty of Medicine, Sumatera Utara University, Medan-Indonesia
Lia Iswara Kusumawati
Consultant in Microbiology Departement, Faculty of Medicine, Sumatera Utara University, Medan-Indonesia
Background: Psoriasis is a chronic, recidive inflammatory skin disease. The main pathogenesis process is currently unknown. This disease is known as a complex disorder, influenced by both genetic susceptibility and environmental factors.
Aim: This study is aimed to analyze and determine the distribution of single nucleotide polymorphism (SNP) in IL-6 gene of psoriasis vulgaris patients and control patients.
Method: This study uses a case-control design to compare SNP in the IL-6 gene between psoriasis vulgaris group and control group.
Results: The most common genotype of the IL-6 gene Rs 1800795 in psoriasis vulgaris patients is GG (dominant homozygous) with a total of 21 patients (46.7%). The most common genotype allele in the control group is Gc (heterozygous) with a total of 27 patients (60%). We observed a significant correlation between the groups (p = 0.044).
Conclusion:
Homozygote for IL-6 allele G (GG) is a prominent finding in the case group, while in the control group heterozygous allele (Gc) is a more common finding, thus suggesting that a patient with dominant homozygote alleles will have a more severe condition when compared to those who have the heterozygote alleles.
