ORIGINAL ARTICLE

Correlation between Otic Capsule Density and Serum 25(OH)D with hearing threshold in chronic kidney disease

Edi Handoko, Indrasworo Dyah, Sucipto Priyo Utomo , Andica Apriannisa

Edi Handoko
ENT Department, dr. Saiful Anwar Public Hospital Malang - East Java Medical Faculty, Brawijaya University, Malang - East Java

Indrasworo Dyah
ENT Department, dr. Saiful Anwar Public Hospital Malang - East Java Medical Faculty, Brawijaya University, Malang - East Java

Sucipto Priyo Utomo
ENT Department, dr. Saiful Anwar Public Hospital Malang - East Java. Email: [email protected]

Andica Apriannisa
Radioliogy Department, dr. Saiful Anwar Public Hospital Malang - East Java
Online First: June 06, 2017 | Cite this Article
Handoko, E., Dyah, I., Utomo, S., Apriannisa, A. 2017. Correlation between Otic Capsule Density and Serum 25(OH)D with hearing threshold in chronic kidney disease. Bali Medical Journal 6(2): 436-439. DOI:10.15562/bmj.v6i2.560


Background: Prevalence of hearing loss in chronic kidney disease is between 40–60%. Its pathomechanism has not been fully understood but could be related to temporal bone remodeling. The bone metabolism disorder in chronic kidney disease is also manifested in vitamin D deficiency. Purpose: This study aims to learn the correlation between otic capsule density and serum 25(OH)D with a hearing threshold in chronic kidney disease without hemodialysis. Method: An observational analytic study with a cross-sectional design involving 36 patients with stage 3 and 4 chronic kidney disease Hearing was examined with Interacoustics AA222 audiometer, otic capsule density was measured using Toshiba Aquilion 128 CT while vitamin D was assessed by ELISA using ORGENTEC 25-OH Vitamin D3/D2 Assay kit. Hearing loss was defined as a hearing threshold over 25 dB on the better hearing ear. Results: Hearing loss was found in 17 of 36 subjects (47.2%). On independent sample t-test, ears with HL(n=44) has lower otic capsule density than ears without (n=28) significantly (p< 0.05; ROI1: 1.867  ± 285 vs 2.095  ± 315 HU; ROI2: 1.864 ±  190 vs 2.051  ± 293 HU). Pearson test showed a significant negative correlation between otic capsule density and hearing threshold (p<0.05; ROI1: r=-0.427; ROI2: r=-0.402). Serum 25(OH)D was insignificantly lower in a subject with HL(n=17) than without (p>0.05; 16.45  ± 6.33 vs. 17.99 + 10.57 ng/mL) and no correlation was found to a hearing threshold in chronic kidney disease. Conclusion: Significant correlation was found between otic capsule density and hearing threshold in predialysis chronic kidney disease. There were no correlation between serum 25(OH)D and hearing threshold and therefore unsuitable as a biomarker for the aforementioned condition.

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