ORIGINAL ARTICLE

Early-changes diagnostics of erythrocytes microrheological features in the model of dyslipidemia development in rats at the late stages of ontogenesis

Vatnikov Yury Anatolyevich , Zavalishina Svetlana Yuryevna, Pliushchikov Vadim Gennadyevich, Kuznetsov Vladimir Ivanovich, Seleznev Sergey Borisovich, Kubatbekov Tursumbai Satymbaevich, Rystsova Ekaterina Olegovna, Parshina Valentina Ivanovna

Vatnikov Yury Anatolyevich
Peoples’ Friendship University of Russia (RUDN University) 6 Miklukho-Maclaya Street, Moscow, 117198, Russian Federation. Email: [email protected]

Zavalishina Svetlana Yuryevna
Kursk Institute of Social Education (branch of the institute RSSU [Russian State Social University]), Kursk

Pliushchikov Vadim Gennadyevich
Peoples’ Friendship University of Russia (RUDN University) 6 Miklukho-Maclaya Street, Moscow, 117198, Russian Federation

Kuznetsov Vladimir Ivanovich
Peoples’ Friendship University of Russia (RUDN University) 6 Miklukho-Maclaya Street, Moscow, 117198, Russian Federation

Seleznev Sergey Borisovich
Peoples’ Friendship University of Russia (RUDN University) 6 Miklukho-Maclaya Street, Moscow, 117198, Russian Federation

Kubatbekov Tursumbai Satymbaevich
Peoples’ Friendship University of Russia (RUDN University) 6 Miklukho-Maclaya Street, Moscow, 117198, Russian Federation

Rystsova Ekaterina Olegovna
Peoples’ Friendship University of Russia (RUDN University) 6 Miklukho-Maclaya Street, Moscow, 117198, Russian Federation

Parshina Valentina Ivanovna
Peoples’ Friendship University of Russia (RUDN University) 6 Miklukho-Maclaya Street, Moscow, 117198, Russian Federation
Online First: March 25, 2017 | Cite this Article
Anatolyevich, V., Yuryevna, Z., Gennadyevich, P., Ivanovich, K., Borisovich, S., Satymbaevich, K., Olegovna, R., Ivanovna, P. 2017. Early-changes diagnostics of erythrocytes microrheological features in the model of dyslipidemia development in rats at the late stages of ontogenesis. Bali Medical Journal 6(1): 211-215. DOI:10.15562/bmj.v6i1.483


In our work we traced the dependence of erythrocyte microrheological features dynamics on the age of experimentally developed dislipidemia in rats. The investigation was fulfilled with the help of initially healthy rats of Vistar line. The experimental group was composed of 105 male rats (34 rats, aged 12 months; 32 rats, aged 18 months; 39 rats, aged 24 months) which were exposed to dislipidemia development by alimentary way. The control group was composed of 91 male rats, including 30 rats aged 12 months, 32 rats aged 18 months, and 29 rats aged 24 months. We applied biochemical, hematological, and statistical methods of investigation. Experimental dislipidemia development in rats showed decrease of plasma antioxidant protection and increase of lipids' peroxidation, which deepened with aging of animals taken into the experiment. With dislipidemia development in experimental rats, we noticed that during the aging process there was a rapid rise in the number of erythrocytes that both reversibly and irreversibly lost their biconcave form. In the experimental group of animals, we noticed during the aging process an increase in erythrocytes' aggregation. Development of abnormalities in erythrocytes' microrheological features in experimental rats exceeded the aging-related changes in the control group. Changes thus found contributed significantly to aggravation in morbidity and heightened sensitivity of animals to negative impacts of environmental factors. Therefore, during the aging process, it is necessary to control more and more strictly the level of blood lipids in order to avoid the development of dislipidemia which becomes acutely dangerous especially during aging because of worsening hemocirculation and rise in the risk of thrombophilia development.

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