Skip to main content Skip to main navigation menu Skip to site footer

Correlation between sebum level and severity of male androgenetic alopecia

  • Regina Maharani Tambunan ,
  • Nelva Karmila Jusuf ,
  • Imam Budi Putra ,

Abstract

Background: Androgenetic alopecia is the main concern hair problem in the male which is characterized by progressive miniaturization of hair follicles. One factor which contributed in androgenetic alopecia progression is sebum level. This study determined the correlation between sebum level and the severity of AGA in men.

Patients and methods: This study was an observational analytic study with a cross sectional method involving 50 male androgenetic alopecia (AGA) patients based on inclusion and exclusion criteria. Recorded age, education, occupation, family history and duration of illness. AGA severity was determined by the Hamilton- Norwood classification I–VII. Sebum levels were measured using Sebumeter® SM 815. The correlation between sebum level and severity of AGA was analyzed using the Gamma correlation test and significant if p-value<0.05.

Results: Most AGA patients were found in the 36–45 age group, had a diploma/bachelor education level, worked in business services and salespeople, had a family history of their father suffering from AGA, and had suffered from AGA for >20 years. Most AGA patients were found in Hamilton-Norwood III (50%) with the most sebum levels were found to be normal (60%). The results of this study showed a positive correlation (p<0.01) with a very strong strength between sebum level and severity of AGA (r=0.94).

Conclusion: There is a very strong correlation between sebum level and severity of AGA.

References

  1. Blume-Peytavi U, Kanti V. Androgenetic alopecia. In: Kang S, Amagai M, Bruckner A, Enk A, Margolis D, McMichael A, editors. Fitzpatrick’s Dermatology. 9th ed. New York: McGraw Hill Education; 2019. p. 1495–506.
  2. Sennett R, Garza L. Androgenetic Alopecia [Internet]. Alopecia. Elsevier; 2019. p. 67–81. Available from: http://dx.doi.org/10.1016/b978-0-323-54825-0.00005-3
  3. Darmaputra IGN, Tirka PSW, Ramaswari PAY, Mahariski PA. Successful alopecia universalis treatment with the combination of cyclosporine and oral corticosteroid: a case report. Bali Med J. 2022;11(2):633–7. Available from: http://dx.doi.org/10.15562/bmj.v11i2.3389
  4. Legiawati L. Alopesia androgenetic. Media Dermato-Venereologica Indones. 2013;40(2):96–101.
  5. Mustika A, Kusuma M, Nasution LH. The correlation between sebum levels and pityriasis versicolor. Bali Med J. 2021;10(3):1015–9. Available from: http://dx.doi.org/10.15562/bmj.v10i3.2859
  6. Yolanda MO, Jusuf NK, Putra IB. Lower facial skin hydration level increases acne vulgaris severity level. Bali Med J. 2021;10(3):1081–4. Available from: http://dx.doi.org/10.15562/bmj.v10i3.2195
  7. Shamloul G, Khachemoune A. An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands. Dermatol Ther. 2021;34(2). Available from: http://dx.doi.org/10.1111/dth.14862
  8. Dinh Q, Sinclair R. Female pattern hair loss: Current treatment concepts. Clin Interv Aging. 2007;2(2):189–99.
  9. Dhurat RS, Daruwalla SB. Androgenetic alopecia: Update on etiology. Dermatological Rev. 2021;2(3):115–21. Available from: http://dx.doi.org/10.1002/der2.58
  10. Rhodes T, Girman CJ, Savin RC, Kaufman KD, Guo S, Lilly FRW, et al. Prevalence of Male Pattern Hair Loss in 18–49 Year Old Men. Dermatologic Surg. 1998;24(12):1330–2. Available from: http://dx.doi.org/10.1111/j.1524-4725.1998.tb00009.x
  11. Xu F, Sheng Y-Y, Mu Z-L, Lou W, Zhou J, Ren Y-T, et al. Prevalence and types of androgenetic alopecia in Shanghai, China: a community-based study. Br J Dermatol. 2009;160(3):629–32. Available from: http://dx.doi.org/10.1111/j.1365-2133.2008.08909.x
  12. Wang TL, Zhou C, Shen YW, Wang XY, Ding XL, Tian S, et al. Prevalence of androgenetic alopecia in China: a community-based study in six cities. Br J Dermatol. 2010;162(4):843–7. Available from: http://dx.doi.org/10.1111/j.1365-2133.2010.09640.x
  13. Legiawati L. Jenis kerontokan rambut dan kebotakan pasien poliklinik kulit dan kelamin RSUPN dr. Cipto Mangunkusumo tahun 2009–2011. Media Dermato-Venereologica Indones. 2013;40(4):159–63.
  14. Magdalena Hutabarat MR, Jusuf NK, Putra IB. Dermocopic Features of Noncicatricial Alopecia. Int J Sci Res Publ. 2019;9(7):p91133. Available from: http://dx.doi.org/10.29322/ijsrp.9.07.2019.p91133
  15. Toruan E. Perbedaan kadar serum steroid 5α-reduktase tipe 2 (SRD5A2) laki-laki dengan dan tanpa alopesia androgenetik. Universitas Sumatera Utara; 2020.
  16. Kure K, Isago T, Hirayama T. Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia). J Cosmet Dermatol. 2015;14(3):178–84. Available from: http://dx.doi.org/10.1111/jocd.12153
  17. Chanprapaph K, Sutharaphan T, Suchonwanit P. Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls. Clin Interv Aging. 2021;16:781–7. Available from: https://pubmed.ncbi.nlm.nih.gov/34007163
  18. Salman KE, Altunay IK, Kucukunal NA, Cerman AA. Frequency, severity and related factors of androgenetic alopecia in dermatology outpatient clinic: hospital-based cross-sectional study in Turkey. An Bras Dermatol. 2017;92(1):35–40. Available from: https://pubmed.ncbi.nlm.nih.gov/28225954
  19. Hu R, Xu F, Han Y, Sheng Y, Qi S, Miao Y, et al. Trichoscopic findings of androgenetic alopecia and their association with disease severity. J Dermatol. 2015;42(6):602–7. Available from: http://dx.doi.org/10.1111/1346-8138.12857
  20. Diana NA, Nurelly N, Sodiqah Y, Nurmadilla N, Surdam Z. Analisis IMT Terhadap Alopesia Androgenik Fakultas Kedokteran, RS Ibnu Sina Dan Menara UMI Makassar. Wal’afiat Hosp J. 2021;2(1):56–62. Available from: http://dx.doi.org/10.33096/whj.v2i1.58
  21. Sinikumpu S-P, Jokelainen J, Auvinen J, Timonen M, Huilaja L. Association between psychosocial distress, sexual disorders, self-esteem and quality of life with male androgenetic alopecia: a population-based study with men at age 46. BMJ Open. 2021;11(12):e049855. Available from: http://dx.doi.org/10.1136/bmjopen-2021-049855
  22. He F, Shen M, Zhao Z, Liu Y, Zhang S, Tang Y, et al. Epidemiology and disease burden of androgenetic alopecia in college freshmen in China: A population-based study. PLoS One. 2022;17(2):e0263912–e0263912. Available from: https://pubmed.ncbi.nlm.nih.gov/35171966
  23. Heilmann‐Heimbach S, Hochfeld LM, Henne SK, Nöthen MM. Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies. Exp Dermatol. 2020;29(9):814–27. Available from: http://dx.doi.org/10.1111/exd.14130
  24. Han S-H, Byun J-W, Lee W-S, Kang H, Kye Y-C, Kim K-H, et al. Quality of life assessment in male patients with androgenetic alopecia: result of a prospective, multicenter study. Ann Dermatol. 2012/07/25. 2012;24(3):311–8. Available from: https://pubmed.ncbi.nlm.nih.gov/22879715
  25. Gupta S, Goyal I, Mahendra A. Quality of Life Assessment in Patients with Androgenetic Alopecia. Int J Trichology. 2019;11(4):147–52. Available from: https://pubmed.ncbi.nlm.nih.gov/31523105
  26. Son K-H, Suh B-S, Jeong H-S, Nam M-W, Kim H, Kim H-C. Relationship between working hours and probability to take alopecia medicine among Korean male workers: a 4-year follow-up study. Ann Occup Environ Med. 2019;31:e12–e12. Available from: https://pubmed.ncbi.nlm.nih.gov/31583103
  27. Yeo IK, Jang WS, Min PK, Cho HR, Cho SW, Hong NS, et al. An epidemiological study of androgenic alopecia in 3114 Korean patients. Clin Exp Dermatol. 2013;39(1):25–9. Available from: http://dx.doi.org/10.1111/ced.12229
  28. Su L-H, Chen TH-H. Association of Androgenetic Alopecia With Smoking and Its Prevalence Among Asian Men. Arch Dermatol. 2007;143(11). Available from: http://dx.doi.org/10.1001/archderm.143.11.1401
  29. Putri AI, Listiawan MY. Pendekatan Diagnosis dan Tata Laksana Alopesia Androgenetik. MEDICINUS. 2022;35(1):3–9. Available from: http://dx.doi.org/10.56951/medicinus.v35i1.88
  30. Lolli F, Pallotti F, Rossi A, Fortuna MC, Caro G, Lenzi A, et al. Androgenetic alopecia: a review. Endocrine. 2017;57(1):9–17. Available from: http://dx.doi.org/10.1007/s12020-017-1280-y
  31. Ding Q, Xu Y-X, Sun W-L, Liu J-J, Deng Y-Y, Wu Q-F, et al. Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort. J Int Med Res. 2020;48(3):300060519897190–300060519897190. Available from: https://pubmed.ncbi.nlm.nih.gov/32188323
  32. Oiwoh S, Akinboro A, Olasode O, Onayemi E. Androgenetic alopecia: Prevalence and clinical characteristics in a South-West Nigerian population. Niger J Med. 2021;30(5):507. Available from: http://dx.doi.org/10.4103/njm.njm_102_21
  33. Jang WS, Son IP, Yeo IK, Park KY, Li K, Kim BJ, et al. The annual changes of clinical manifestation of androgenetic alopecia clinic in korean males and females: a outpatient-based study. Ann Dermatol. 2013/05/10. 2013;25(2):181–8. Available from: https://pubmed.ncbi.nlm.nih.gov/23717009
  34. Chovarda E, Sotiriou E, Lazaridou E, Vakirlis E, Ioannides D. The role of prostaglandins in androgenetic alopecia. Int J Dermatol. 2021;60(6):730–5. Available from: http://dx.doi.org/10.1111/ijd.15378
  35. Gupta M, Mysore V. Classifications of Patterned Hair Loss: A Review. J Cutan Aesthet Surg. 2016;9(1):3–12. Available from: https://pubmed.ncbi.nlm.nih.gov/27081243
  36. Ummiti A, Priya PS, Chandravathi PL, Kumar CS. Correlation of Trichoscopic Findings in Androgenetic Alopecia and the Disease Severity. Int J Trichology. 2019;11(3):118–22. Available from: https://pubmed.ncbi.nlm.nih.gov/31360040
  37. Sanke S, Samudrala S, Yadav A, Chander R, Goyal R. Study of serum vitamin D levels in men with premature androgenetic alopecia. Int J Dermatol. 2020;59(9):1113–6. Available from: http://dx.doi.org/10.1111/ijd.14982
  38. Kim S, Shin S, Kim S-N, Na Y. Understanding the Characteristics of the Scalp for Developing Scalp Care Products. J Cosmet Dermatological Sci Appl. 2021;11(03):204–16. Available from: http://dx.doi.org/10.4236/jcdsa.2021.113018
  39. Tranggono R, Latifah F. Buku pegangan ilmu pengetahuan kosmetik [Internet]. 1st ed. Jakarta: PT Gramedia; 2007. Available from: https://play.google.com/books/reader?id=Zg5hDwAAQBAJ&pg=GBS.PR3&hl=id&printsec=f rontcover.
  40. Rahrovan S, Fanian F, Mehryan P, Humbert P, Firooz A. Male versus female skin: What dermatologists and cosmeticians should know. Int J women’s dermatology. 2018;4(3):122–30. Available from: https://pubmed.ncbi.nlm.nih.gov/30175213
  41. Pouradier F, Liu C, Wares J, Yokoyama E, Collaudin C, Panhard S, et al. The worldwide diversity of scalp seborrhoea, as daily experienced by seven human ethnic groups. Int J Cosmet Sci. 2017;39(6):629–36. Available from: http://dx.doi.org/10.1111/ics.12425
  42. Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, et al. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med. 2012;4(126):126ra34-126ra34. Available from: https://pubmed.ncbi.nlm.nih.gov/22440736
  43. Fields JR, Vonu PM, Monir RL, Schoch JJ. Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review. Dermatol Ther. 2020;33(1). Available from: http://dx.doi.org/10.1111/dth.13202
  44. Suzuki K, Inoue M, Cho O, Mizutani R, Shimizu Y, Nagahama T, et al. Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia. Microorganisms. 2021;9(10):2132. Available from: https://pubmed.ncbi.nlm.nih.gov/34683453
  45. Katzer T, Leite Junior A, Beck R, da Silva C. Physiopathology and current treatments of androgenetic alopecia: Going beyond androgens and anti‐androgens. Dermatol Ther. 2019;32(5). Available from: http://dx.doi.org/10.1111/dth.13059
  46. Ceruti JM, Leirós GJ, Balañá ME. Androgens and androgen receptor action in skin and hair follicles. Mol Cell Endocrinol. 2018;465:122–33. Available from: http://dx.doi.org/10.1016/j.mce.2017.09.009
  47. Gentile P, Scioli MG, Bielli A, Orlandi A, Cervelli V. Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss. Stem cell Investig. 2017;4:58. Available from: https://pubmed.ncbi.nlm.nih.gov/28725654

How to Cite

Tambunan, R. M., Jusuf, N. K., & Putra, I. B. (2023). Correlation between sebum level and severity of male androgenetic alopecia. Bali Medical Journal, 12(2), 1578–1584. https://doi.org/10.15562/bmj.v12i2.4084

HTML
0

Total
0

Share

Search Panel

Regina Maharani Tambunan
Google Scholar
Pubmed
BMJ Journal


Nelva Karmila Jusuf
Google Scholar
Pubmed
BMJ Journal


Imam Budi Putra
Google Scholar
Pubmed
BMJ Journal