PREVALENCE AND QUALITY OF LIFE OF PEMPHIGUS PATIENTS AT SANGLAH GENERAL HOSPITAL BALI-INDONESIA
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- DOI: https://doi.org/10.15562/bmj.v2i1.38  |
- Published: 2013-01-01
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Objectives: Pemphigus vulgaris (PV) is an autoimmune-blistering disease of the skin and mucousÂ membranes caused by auto-antibodies against desmoglein-3 (Dsg-3) on the keratinocyte cell surfaceÂ of squamous stratified epithelia. Pemphigus is a life-threatening autoimmune bullous disease resultingÂ in the widespread denudation of skin and mucous membrane and severe impact of quality of life. The
purpose of this study was to evaluate retrospectively the prevalence of pemphigus and to elucidate theÂ clinical variants, clinical course, prognosis and quality of life (QOL) of pemphigus patients afterÂ discharge from hospitalized.
Method: Observational non analytical retrospective study was conductedÂ by observation of the medical records of all the newly registered patients with pemphigus at Sanglah
General Hospital in Bali-Indonesia during the period of January 1995 and December 2002, andÂ analyzed with regard to personal statistic, history of the diseases including onset, site of affected,Â symptoms, clinical diagnosis, severity, associated illness, therapy, and quality of life based on the
Results: During the 8-year periods studies, 33 pemphigus patients were admitted,Â represented 5.8 % of all patients admitted in our in-patient ward during the periods. Our patientsÂ consist of female 20 patients (60.6 %) and male 13 patients (39.4 %). The most common of clinical
type was pemphigus vulgaris 26 patients (78.78 %), followed by pemphigus foleaceous andÂ pemphigus vegetans. Six patients (18.18 %) of 16 severe patients with severe condition at the clinicalÂ course of the diseases was death during the course of hospitalized. A number of 2 patients, in this
study were observed with severe impact of quality of life.
Conclusion: Our finding showed thatÂ pemphigus vulgaris is common type of our cases has a relatively high prevalence our hospital (5.8 %),Â and relatively high death rate (18.18 %). In our study, systemic corticosteroid was still applied until
present for life saving drug for Pemphigus.