ORIGINAL ARTICLE

High Level of Serum Cartilage Oligomeric Matrix Protein and Plasma Interleukin-6 Increase the Risk of Ultrasound-detected Synovial Inflammation in Knee Osteoarthritis

Elysanti Dwi Martadiani , I Ketut Siki Kawiyana, Triyono Karwawan Sukana Priya, Tjokorda Raka Putra, Gede Raka Widiana, Anak Agung Gede Sudewa Djelantik, Anak Agung Raka Sudewi, I Wayan Putu Sutirta Yasa, I Nyoman Mantik Astawa

Elysanti Dwi Martadiani
Radiology Department, Medical Faculty, Udayana University-Sanglah General Hospital, Denpasar-Bali, Indonesia. Email: [email protected]

I Ketut Siki Kawiyana
Orthopaedic and Traumatology Department, Udayana Medical Faculty-Sanglah General Hospital, Denpasar-Bali, Indonesia

Triyono Karwawan Sukana Priya
Radiology Department, Airlangga Medical Faculty-Dr. Soetomo Hospital, Surabaya, Indonesia

Tjokorda Raka Putra
Internal Medicine Department, Udayana Medical Faculty-Sanglah General Hospital, Denpasar-Bali, Indonesia

Gede Raka Widiana
Internal Medicine Department, Udayana Medical Faculty-Sanglah General Hospital, Denpasar-Bali, Indonesia

Anak Agung Gede Sudewa Djelantik
Clinical Pathology Department, Udayana Medical Faculty-Sanglah General Hospital, Denpasar-Bali, Indonesia

Anak Agung Raka Sudewi
Neurology Department, Udayana Medical Faculty-Sanglah General Hospital, Denpasar-Bali, Indonesia

I Wayan Putu Sutirta Yasa
Clinical Pathology Department, Udayana Medical Faculty-Sanglah General Hospital, Denpasar-Bali, Indonesia

I Nyoman Mantik Astawa
Veterinary Faculty, Udayana University, Bali, Indonesia
Online First: January 04, 2017 | Cite this Article
Martadiani, E., Kawiyana, I., Priya, T., Putra, T., Widiana, G., Djelantik, A., Sudewi, A., Yasa, I., Astawa, I. 2017. High Level of Serum Cartilage Oligomeric Matrix Protein and Plasma Interleukin-6 Increase the Risk of Ultrasound-detected Synovial Inflammation in Knee Osteoarthritis. Bali Medical Journal 6(1): 23-30. DOI:10.15562/bmj.v6i1.350


Background: Inflammation of the synovial membrane involved in knee osteoarthritis (OA) pathomechanism. Cartilage oligomeric matrix protein (COMP) is a cartilage degradation product that has been considered as a biomarker of OA. Interleukin-6 (IL-6) is an inflammatory mediator involved in the pathogenesis of synovial inflammation in knee OA. this study was conducted to proof whether high level of serum COMP and plasma IL-6 increase the risk of synovial inflammation in knee OA. Methods: This was a case control study to proof about the risk of synovial inflammation in primary knee OA patients who were exposed by high level of circulating serum COMP and plasma IL-6. Every case was matched with his/ her control using pair by pair method (pair-matched). Research data was analyzed using statistic computer software program. Results: There were 56 subjects in case group and 56 subjects in control group. Bivariate analysis found that serum level of COMP gave risk for having synovial inflammation 5.5 times higher than control group (p<0.001). High level of plasma IL-6 which gave risk of synovial inflammation 2.88 times higher than control group (p<0.05). Multivariate analysis found that high level of serum COMP and plasma IL-6 was still significantly increased the risk factors for the development of synovial inflammation in knee OA (adjusted-OR= 3, p<0.05 for high level of serum COMP; and adjusted-OR=2.7, p<0.05 for high level of plasma IL-6). Conclusion: High level of serum COMP and also high level of plasma IL-6 is proven increasing the risk of synovial inflammation in knee OA.

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