Association between metabolic syndrome and knee osteoarthritis

Ardyarini Dyah  Savitri; Lysa  Veterini; Meidyta Sinantryana  Widyaswari; Diaz Syafrie  Abdillah

doi:10.15562/bmj.v11i3.3454

Association between metabolic syndrome and knee osteoarthritis

Ardyarini Dyah Savitri ,

Lysa Veterini ,

Meidyta Sinantryana Widyaswari ,

Diaz Syafrie Abdillah ,

pdf |
DOI: https://doi.org/10.15562/bmj.v11i3.3454 |
Published: 2022-09-09

Abstract

Introduction: The inflammatory process underlies either osteoarthritis (OA) or metabolic syndrome. Systemic inflammation that occurs in the metabolic syndrome will result in the production of inflammatory cytokines and activation of macrophages and chondrocytes. This can affect the entire body including joints and the surrounding tissues, causing OA. Type 2 Diabetes Mellitus (DMT2) and hypertension are the first and second most common metabolic syndrome components found in OA patients. This study aimed to determine the relationship between metabolic syndrome and knee OA in DMT2 patients with hypertension.

Methods: By using an analytic observational method and cross-sectional design, this study involved the medical records of patients with DMT2. The sample consisted of 50 medical records selected by using the purposive sampling technique and fulfilling the inclusion and exclusion criteria.

Results: This study involved 25 medical records of patients with and without knee (genu) OA. The characteristics of the sample were as follows: 1 medical record of patient aged 36-45 years, 18 medical records of patients aged 46-55 years, 16 medical records of patients aged 56-65 years, 15 medical records of patients aged > 65 years, 21 medical records of male patients, 29 medical records of female patients, 27 medical records with metabolic syndrome, and 23 medical records without metabolic syndrome. The association between metabolic syndrome and knee (genu) OA was analyzed by using the Chi-Square Test using the SPSS application, where the results showed a significance value of p < 0.05 (p = 0.001).

Conclusion: This study shows that there is a significant association between metabolic syndrome and knee (genu) OA.

References

CDC (Centers of Desease Control and Prevention). Osteoarthritis (OA) [Internet]. 2019. Available from: https://www.cdc.gov/arthritis/basics/osteoarthritis.htm
Tjokroprawiro, A., Setiawan, P. B., Effendi, C., & Santoso D. Buku Ajar Ilmu Penyakit Dalam. In A. Tjokroprawiro, P. B. Setiawan, C. Effendi, & D. Santoso (Eds.). 2nd ed. Airlangga University Press.; 2015.
Felix Bronner and Mary C. Farach-Carson. Bone and Osteoarthritis. Bone and Osteoarthritis. London : Springer,; 2007.
Davey P. At a Glance Medicine - Google Books [Internet]. Erlangga; 2012. 383 p. Available from: https://www.google.co.id/books/edition/At_a_Glance_Medicine/wzIGJflmD4gC?hl=id&gbpv=1&dq=osteomielitis+adalah&pg=PA383&printsec=frontcover
Basaran S, Guzel R, Seydaoglu G, Guler-Uysal F. Validity, reliability, and comparison of the WOMAC osteoarthritis index and Lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis. Clin Rheumatol. 2010 Jul;29(7):749–56.
Yanuarty M, Suntoko B. Hubungan Antara Faktor Risiko Osteoartritis Lutut Dengan Nyeri, Disabilitas, Dan Berat Ringannya Osteoartritis. J Kedokt Diponegoro. 2014;3(1):111411.
Wulandari, M. Y., & Isfandiar MA. Kaitan sindroma metabolik dan gaya hidup dengan gejala komplikasi mikrovaskuler. J Berk Epidemiol. 2013;1:224–33.
Rini. Sindrom Metabolik. J Major [Internet]. 2015;4(4):88–93. Available from: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Sindrom+Metabolik#1
Courties A, Sellam J, Berenbaum F. Metabolic syndrome-associated osteoarthritis. Curr Opin Rheumatol. 2017 Mar;29(2):214–22.
Purnomo, Hery Djagat (Program Pendidikan Dokte Spesialis-1 BIPDFUD. Gangguan Musculoskeletal pada Penderita Diabetes Melitus di RSUP Dr. Kariadi Semarang. 2002.
Juliana R. Karakteristik Penderita Osteoartritis Rawat Jalan Di Rsud Dr.Pirngadi Medan Tahun 2015. Unversitas Sumatra Utara. 2015;
Haq SA, Davatchi F. Osteoarthritis of the knees in the COPCORD world. Int J Rheum Dis. 2011;14(2):122–9.
Baumbach L, Roos EM, Lykkegaard J, Thomsen KS, Kristensen PL, Christensen AI, et al. Patients with osteoarthritis are least likely to receive lifestyle advice compared with patients with diabetes and hypertension: A national health survey study from Denmark. Osteoarthr Cartil Open [Internet]. 2020;2(3):100067. Available from: https://doi.org/10.1016/j.ocarto.2020.100067
Prawati. Faktor-faktor Risiko Osteoartritis Lutut. Tesis [Internet]. 2017; Available from: http://eprints.undip.ac.id/17308/1/Eka_Pratiwi_Maharani.pdf
Abdillah DS, Savitri AD, . E. Correlation of Metabolic Syndrome With Genu Osteoarthritis in Type 2 Diabetes Mellitus Patients. Curr Intern Med Res Pract Surabaya J. 2022;3(1):1.
Santoso A. Hubungan Kendali Glukosa Darah dengan Osteoartritis Lutut pada Pasien DM di RSD Dr. Soebandi (The Relationship between Blood Glucose Control and Knee Osteoarthritis in DM Patients at Dr. Soebandi Hospital). In 2014.
Rahman MM, Cibere J, Anis AH, Goldsmith CH, Kopec JA. Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study. Int J Rheumatol. 2014;2014:620920.
Wang H, Cheng Y, Shao D, Chen J, Sang Y, Gui T, et al. Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis. Evid Based Complement Alternat Med. 2016;2016:7242478.
Dickson BM, Roelofs AJ, Rochford JJ, Wilson HM, De Bari C. The burden of metabolic syndrome on osteoarthritic joints. Arthritis Res Ther. 2019 Dec;21(1):289.
Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, et al. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthr Cartil. 2012 Nov;20(11):1217–26.

[1] CDC (Centers of Desease Control and Prevention). Osteoarthritis (OA) [Internet]. 2019. Available from: https://www.cdc.gov/arthritis/basics/osteoarthritis.htm

[2] Tjokroprawiro, A., Setiawan, P. B., Effendi, C., & Santoso D. Buku Ajar Ilmu Penyakit Dalam. In A. Tjokroprawiro, P. B. Setiawan, C. Effendi, & D. Santoso (Eds.). 2nd ed. Airlangga University Press.; 2015.

[3] Felix Bronner and Mary C. Farach-Carson. Bone and Osteoarthritis. Bone and Osteoarthritis. London : Springer,; 2007.

[4] Davey P. At a Glance Medicine - Google Books [Internet]. Erlangga; 2012. 383 p. Available from: https://www.google.co.id/books/edition/At_a_Glance_Medicine/wzIGJflmD4gC?hl=id&gbpv=1&dq=osteomielitis+adalah&pg=PA383&printsec=frontcover

[5] Basaran S, Guzel R, Seydaoglu G, Guler-Uysal F. Validity, reliability, and comparison of the WOMAC osteoarthritis index and Lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis. Clin Rheumatol. 2010 Jul;29(7):749–56.

[6] Yanuarty M, Suntoko B. Hubungan Antara Faktor Risiko Osteoartritis Lutut Dengan Nyeri, Disabilitas, Dan Berat Ringannya Osteoartritis. J Kedokt Diponegoro. 2014;3(1):111411.

[7] Wulandari, M. Y., & Isfandiar MA. Kaitan sindroma metabolik dan gaya hidup dengan gejala komplikasi mikrovaskuler. J Berk Epidemiol. 2013;1:224–33.

[8] Rini. Sindrom Metabolik. J Major [Internet]. 2015;4(4):88–93. Available from: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Sindrom+Metabolik#1

[9] Courties A, Sellam J, Berenbaum F. Metabolic syndrome-associated osteoarthritis. Curr Opin Rheumatol. 2017 Mar;29(2):214–22.

[10] Purnomo, Hery Djagat (Program Pendidikan Dokte Spesialis-1 BIPDFUD. Gangguan Musculoskeletal pada Penderita Diabetes Melitus di RSUP Dr. Kariadi Semarang. 2002.

[11] Juliana R. Karakteristik Penderita Osteoartritis Rawat Jalan Di Rsud Dr.Pirngadi Medan Tahun 2015. Unversitas Sumatra Utara. 2015;

[12] Haq SA, Davatchi F. Osteoarthritis of the knees in the COPCORD world. Int J Rheum Dis. 2011;14(2):122–9.

[13] Baumbach L, Roos EM, Lykkegaard J, Thomsen KS, Kristensen PL, Christensen AI, et al. Patients with osteoarthritis are least likely to receive lifestyle advice compared with patients with diabetes and hypertension: A national health survey study from Denmark. Osteoarthr Cartil Open [Internet]. 2020;2(3):100067. Available from: https://doi.org/10.1016/j.ocarto.2020.100067

[14] Prawati. Faktor-faktor Risiko Osteoartritis Lutut. Tesis [Internet]. 2017; Available from: http://eprints.undip.ac.id/17308/1/Eka_Pratiwi_Maharani.pdf

[15] Abdillah DS, Savitri AD, . E. Correlation of Metabolic Syndrome With Genu Osteoarthritis in Type 2 Diabetes Mellitus Patients. Curr Intern Med Res Pract Surabaya J. 2022;3(1):1.

[16] Santoso A. Hubungan Kendali Glukosa Darah dengan Osteoartritis Lutut pada Pasien DM di RSD Dr. Soebandi (The Relationship between Blood Glucose Control and Knee Osteoarthritis in DM Patients at Dr. Soebandi Hospital). In 2014.

[17] Rahman MM, Cibere J, Anis AH, Goldsmith CH, Kopec JA. Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study. Int J Rheumatol. 2014;2014:620920.

[18] Wang H, Cheng Y, Shao D, Chen J, Sang Y, Gui T, et al. Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis. Evid Based Complement Alternat Med. 2016;2016:7242478.

[19] Dickson BM, Roelofs AJ, Rochford JJ, Wilson HM, De Bari C. The burden of metabolic syndrome on osteoarthritic joints. Arthritis Res Ther. 2019 Dec;21(1):289.

[20] Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, et al. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthr Cartil. 2012 Nov;20(11):1217–26.

Association between metabolic syndrome and knee osteoarthritis

Abstract

References

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