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The protective effect of intermittent fasting and physical exercise on obesity through changes in muscle diameter

  • Aisyah ,
  • Hotimah Masdan Salim ,

Abstract

Introduction: Obesity is a cause of metabolic syndrome. Intermittent fasting is a method that is quite popular today, and this is an alternative method to lose weight compared to the traditional method of undergoing calorie restriction (20-40% reduction in daily calorie intake) and/or physical activity. However, the effect of intermittent fasting and physical exercise on changes in the muscle remains unclear. This study aimed to determine the changes in muscle histology in intermittent fasting and physical exercise in obese mice.

Methods: 8-weeks old mice were given a high-fat diet for two weeks and then grouped into four groups (a control group, group two as a group with a high-fat diet, group three with a high-fat diet which was given physical exercise, and group four was a high-fat diet which was given fasting for 8 hours 5 days a week, for two weeks). Histological analysis was performed to see the changes in the muscles with hematoxylin staining at 40 times magnification.

Results: The fasting and physical exercise group were significantly less weight gain. The histological results found that the muscle diameter widened in the physical exercise group compared to the high-fat diet group (p<0.05). In comparison, the fasting group was found to have almost the same muscle diameter as the control group without the high-fat diet (p<0.05).

Conclusion: Both intermittent fasting and exercise were effective in reducing body weight, whereas intermittent fasting is more effective than exercise in maintaining muscle mass by maintaining muscle diameter to prevent obesity.

References

  1. Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL. Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Ther Adv Cardiovasc Dis. 2017;11(8):215–25.
  2. Larsson L, Degens H, Li M, Salviati L, Lee Y Il, Thompson W, et al. Sarcopenia: Aging-Related Loss of Muscle Mass and Function. Physiol Rev. 2019;99(1):427–511.
  3. Furrer R, Bravenboer N, Kos D, Lips P, de Haan A, Jaspers RT. Effects of concurrent training on oxidative capacity in rat gastrocnemius muscle. Med Sci Sports Exerc. 2013;45(9):674–83.
  4. Linden MA, Fletcher JA, Morris EM, Meers GM, Kearney ML, Crissey JM, et al. Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats. Am J Physiol Metab. 2014;306(3):E300–10.
  5. Hartman AL, Rubenstein JE, Kossoff EH. Intermittent fasting: a "new" historical strategy for controlling seizures? Epilepsy Res. 2012/12/01. 2013;104(3):275–9.
  6. Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2016/10/31. 2017;39:46–58.
  7. Wilson RA, Deasy W, Stathis CG, Hayes A, Cooke MB. Intermittent Fasting with or without Exercise Prevents Weight Gain and Improves Lipids in Diet-Induced Obese Mice. Nutrients. 2018;10(3):346.
  8. Barnosky AR, Hoddy KK, Unterman TG, Varady KA. Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Transl Res. 2014;164(4):302–11.
  9. Sinaga M, Teshome MS, Kidane R, Yemane T, Tegene E, Lindstrom D, et al. Metabolic Effects of Fasting and Animal Source Food Avoidance in an Ethiopian Adult Cohort. Sci Rep. 2019;9(1):1–9.
  10. Bradley RL, Jeon JY, Liu F-F, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Metab. 2008;295(3):E586–94.
  11. Hou J, He C, He W, Yang M, Luo X, Li C. Obesity and Bone Health: A Complex Link. Front cell Dev Biol. 2020;8:600181.

How to Cite

Aisyah, & Salim, H. M. (2022). The protective effect of intermittent fasting and physical exercise on obesity through changes in muscle diameter. Bali Medical Journal, 11(2), 897–899. https://doi.org/10.15562/bmj.v11i2.3150

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