ORIGINAL ARTICLE

Relationship of Heme Oxygenase-1 (HO-1) Level with Onset and Severity in Normotensive Pregnancy and Severe Preeclampsia

John Johannes Wantania , Christian Homenta, Billy Johnson Kepel

John Johannes Wantania
Maternal Fetal Medicine Consultant in Department of Obstetrics and Gynecology, Faculty of Medicine University Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital, Manado-Indonesia. Email: [email protected]

Christian Homenta
Obstetrician and Gynecologist in Department of Obstetrics and Gynecology, Faculty of Medicine University Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital, Manado-Indonesia

Billy Johnson Kepel
Statistician Consultant in Department of Obstetrics and Gynecology, Faculty of Medicine University Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital, Manado-Indonesia
Online First: August 16, 2016 | Cite this Article
Wantania, J., Homenta, C., Kepel, B. 2016. Relationship of Heme Oxygenase-1 (HO-1) Level with Onset and Severity in Normotensive Pregnancy and Severe Preeclampsia. Bali Medical Journal 5(1): 105-109. DOI:10.15562/bmj.v5i1.267


Background: Preeclampsia still becomes a major problem in pregnancies. Various evidences showed that heme oxygenase-1 (HO-1) is very important in pregnancy. This study aims to understand the relationship of heme oxygenase-1 level with onset and severity in normotensive pregnancy and severe preeclampsia. Methods: This is a cross sectional analytic comparative study, the subjects consisted of 26 patients with normotensive pregnancies and 26 patients with severe preeclampsia. Blood samples from women with < 34 / ≥ 34 weeks’ normotensive pregnancies and women with severe preeclampsia were taken. HO-1 ELISA kit used to quantitate heme oxygenase-1 level in samples. Results: The level of heme oxygenase-1 in normotensive pregnant women < 34 weeks lower than severe preeclampsia pregnant women < 34 weeks (3.28 ± 0.46 ng/mL vs 4.20 ± 0.64 ng/mL, p=0.003, respectively). The median level of heme oxygenase-1 in normotensive pregnant women ≥ 34 weeks was 2.96 (2.414.39) ng/mL, while severe preeclampsia pregnant women ≥ 34 weeks was 3.52 (2.885.43) ng/mL, (p=0.040). The median level of heme oxygenase-1 in normotensive pregnant women was 3.04 (2.414.39) ng/mL, while severe preeclampsia pregnant women was 3.68 (2.885.67) ng/mL, (p=0.001). Conclusions: There is correlation between the incidence of severe preeclampsia with heme oxygenase-1 level in < 34 and ≥ 34 weeks of pregnancy. There is a significant difference between the level of heme oxygenase-1 in pregnant women with severe preeclampsia and in women with normotensive pregnancy.

 

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