REVIEW

Adipose-Derived Stem Cells (ADSCs): a review article

Ida Bagus Putra Pramana , Anak Agung Gde Oka, I Nyoman Mantik Astawa, Tjokorda Gde Bagus Mahadewa

Ida Bagus Putra Pramana
Department of Urology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia. Email: [email protected]

Anak Agung Gde Oka
Department of Urology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia

I Nyoman Mantik Astawa
Department of Animal Disease, Faculty of Veterinary Medicine, Universitas Udayana, Bali, Indonesia

Tjokorda Gde Bagus Mahadewa
Department of Neurosurgery, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
Online First: October 23, 2021 | Cite this Article
Pramana, I., Oka, A., Astawa, I., Mahadewa, T. 2021. Adipose-Derived Stem Cells (ADSCs): a review article. Bali Medical Journal 10(3): 881-886. DOI:10.15562/bmj.v10i3.2631


Introduction: Stem Cells (SC) are cells having characteristic features of self-renewal and plasticity that can differentiate and proliferate into many types of cells to form an individual. This literature study aims to evaluate the Adipose-Derived Stem Cells (ADSCs) comprehensively.

Methods: A comprehensive literature search was conducted by the author to obtain relevant studies from PubMed, MEDLINE, Embase, PreMEDLINE, Embase, PsycINFO, Scopus, and Cochrane for the last fifteen years. The author sought articles with the following keywords: Adipose-Derived Stem Cells, AND Fibrosis, OR Wound Healing, OR Growth Factor, hypoxic culture OR, Normoxic Culture, OR cytokine.

Results:  ADSCs become one of the strong potential stem cell-based therapies, for instance, preventing fibrosis tissue formation in the wound healing process. The source is mainly on the body’s surface, and harvesting using a minimally invasive procedure made ADSCs superior to the other stem cell sources. Using a better precondition technique, such as the hypoxia precondition technique, can increase the proliferation of stem cells and the viability of stem cells.

Conclusion: ADSCs are a source of visible cell-based therapy to be currently used. ADSCs can counteract fibrosis by the anti-inflammatory and anti fibrosis effects.

References

Sylvester KG, Longaker MT. Stem cells: review and update. Arch Surg. 2004;139(1):93-99.

Frese L, Dijkman PE, Hoerstrup SP. Adipose Tissue-Derived Stem Cells in Regenerative Medicine. Transfus Med Hemother. 2016;43(4):268-274.

Zakrzewski W, Dobrzy?ski M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019;10(1):68.

Castiglione F, Dewulf K, Hakim L, Weyne E, Montorsi F, Russo A, et al. Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats. Eur Urol. 2016;70(6):1032-1041.

Seo Y, Shin TH, Kim HS. Current Strategies to Enhance Adipose Stem Cell Function: An Update. Int J Mol Sci. 2019;20(15):3827.

Si Z, Wang X, Sun C, Kang Y, Xu J, Wang X, et al. Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies. Biomed Pharmacother. 2019;114:108765.

Li P, Guo X. A review: therapeutic potential of adipose-derived stem cells in cutaneous wound healing and regeneration. Stem Cell Res Ther. 2018;9(1):302.

Kartiko BH, Siswanto FM, Purwata TE. Mesenchymal stem cell (MSC) as a potential cell therapy for immune related disease. Bali Medical Journal. 2017;6(1):38-43.

Pham PV, Vu NB, Phan NK. Hypoxia promotes adipose-derived stem cell proliferation via VEGF. Biomed Res Ther. 2016;3(1):476–82.

Heo SC, Jeon ES, Lee IH, Kim HS, Kim MB, Kim JH. Tumor necrosis factor-?-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms. J Invest Dermatol. 2011;131(7):1559-1567.

Xu L, Wang X, Wang J, Liu D, Wang Y, Huang Z, et al. Hypoxia-induced secretion of IL-10 from adipose-derived mesenchymal stem cell promotes growth and cancer stem cell properties of Burkitt lymphoma. Tumour Biol. 2016;37(6):7835-42.

Ceccarelli S, Pontecorvi P, Anastasiadou E, Napoli C, Marchese C. Immunomodulatory Effect of Adipose-Derived Stem Cells: The Cutting Edge of Clinical Application. Front Cell Dev Biol. 2020;8:236.

Cai C, Kilari S, Zhao C, Simeon ML, Misra A, Li Y, et al. Therapeutic Effect of Adipose Derived Mesenchymal Stem Cell Transplantation in Reducing Restenosis in a Murine Angioplasty Model. J Am Soc Nephrol. 2020;31(8):1781-1795.

Li JZ, Cao TH, Han JC, Qu H, Jiang SQ, Xie BD, et al. Comparison of adipose and bone marrow derived stem cells in protecting against oxLDLinduced inflammation in M1 Macrophage Derived foam cells. Mol Med Rep. 2019;19(4):2660-2670.

Jiang H, Gao Q, Che X, Zhu L, Zhang Z, Chen Y, et al. Inhibition of penile tunica albuginea myofibroblasts activity by adipose-derived stem cells. Exp Ther Med. 2017;14(5):5149-5156.

Ma Y, Kakudo N, Morimoto N, Lai F, Taketani S, Kusumoto K. Fibroblast growth factor-2 stimulates proliferation of human adipose-derived stem cells via Src activation. Stem Cell Res Ther. 2019;10(1):350.

Liguori TTA, Liguori GR, Moreira LFP, Harmsen MC. Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-?1-induced differentiation of human cardiac fibroblasts into myofibroblasts. Sci Rep. 2018;8(1):16633.

Verhoekx JSN, Mudera V, Walbeehm ET, Hovius SER. Adipose-derived stem cells inhibit the contractile myofibroblast in Dupuytren's disease. Plast Reconstr Surg. 2013;132(5):1139-1148.

Jotzu C, Alt E, Welte G, Li J, Hennessy BT, Devarajan E, et al. Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors. Cell Oncol (Dordr). 2011;34(1):55-67.

Fotia C, Massa A, Boriani F, Baldini N, Granchi D. Hypoxia enhances proliferation and stemness of human adipose-derived mesenchymal stem cells. Cytotechnology. 2015;67(6):1073-1084.


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