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High Level of Soluble FMS-Like Tyrosine Kinase-1 (sFlt-1) Serum in Pregnancy as a Risk Factor of Preeclampsia

I Gede Mega Putra , I Gede Putu Surya, A.A Sagung Istri Mas Pratiwi

I Gede Mega Putra
Obstetrician of Urogynecology Division, Department of Obstetrics and Gynecology, Udayana University Sanglah Hospital Bali. Email: [email protected]

I Gede Putu Surya
Consultant of Urogynecology Division, Department of Obstetrics and Gynecology, Udayana University Sanglah Hospital Bali

A.A Sagung Istri Mas Pratiwi
Resident, Department of Obstetrics and Gynecology, Udayana University Sanglah Hospital Bali
Online First: July 18, 2016 | Cite this Article
Mega Putra, I., Surya, I., Pratiwi, A. 2016. High Level of Soluble FMS-Like Tyrosine Kinase-1 (sFlt-1) Serum in Pregnancy as a Risk Factor of Preeclampsia. Bali Medical Journal 5(2): 322-325. DOI:10.15562/bmj.v5i2.247


Background: Recently, etiology and pathogenesis of preeclampsia remain unknown. One of the theory indicating that hypoxia and ischemic placenta caused by abnormal cytotrophoblast invasion in preeclampsia. Soluble Fms-like tyrosine kinase-1 (sFlt-1) serum as a laboratory marker of hypoxia condition that contributes to the occurrence of endothelial damage and clinical manifestations in preeclampsia. Objective: This study was aimed at proving that high level of soluble Fms-like tyrosine kinase-1 (sFlt-1) serum in pregnancy as a risk factor for preeclampsia. Methods: This study was a case control. Among 58 pregnant women studied, 29 women with preeclampsia as a case group and 29 women with normal pregnancy as a control group. Soluble Fms-like tyrosine kinase-1 (sFlt-1) serum was analyzed in the Prodia Laboratory. Collected data were tested for normality using Kolmogorov-Smirnov, then analyzed with independent sample test. Chi-Square test used to determine soluble Fms-like tyrosine kinase-1 (sFlt-1) serum level in preeclampsia. Results: This research concluded that the average level of soluble Fms-like tyrosine kinase-1 (sFlt-1) serum in preeclampsia were 11231.00 ± 8390.3 pg/mL and 3981.62 ± 4921.5 pg/mL in normal pregnancy. Analysis of significance with independent t-test concluded that the value of t = 4.01 and p = 0.001. This mean the average levels of soluble Fms-like tyrosine kinase-1 (sFlt-1)serum levels in both groups were difference significantly (p <0.05). Based on the cut-off point of sFlt-1 serum levels was 4505.50 pg/mL with 79.3% sensitivity and 82.8% specificity, the relative risk of preeclampsia was 18 times (OR = 18.40, IK 95% = 4.93 to 68.70, p = 0.001). Conclusion:  Based on this research, high levels of soluble Fms-like tyrosine kinase-1 (sFlt-1) in pregnancy was proved as a risk factor for preeclampsia.

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