ORIGINAL ARTICLE

Type of anemia correlate with ferritin levels in patients with Chronic Kidney Disease (CKD): a cross sectional study

Linda Rosita , Nurrin Jannatin, Barkah Djaka Purwanto, Tri Ratnaningsih, Usi Sukorini, Zulkifli Supranto Simanjuntak, Rahma Yuantari

Linda Rosita
Department of Clinical Pathology, Universitas Islam Indonesia, Yogyakarta, Indonesia. Email: [email protected]

Nurrin Jannatin
Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia

Barkah Djaka Purwanto
Department of Internal Medicine, Faculty of Medicine, Universitas Ahmad Dahlan, Bantul, Yogyakarta, Indonesia

Tri Ratnaningsih
Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Usi Sukorini
Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Zulkifli Supranto Simanjuntak
Doloksanggul District Hospital, North Sumatera, Indonesia

Rahma Yuantari
Department of Clinical Pathology, Universitas Islam Indonesia, Yogyakarta, Indonesia
Online First: September 15, 2021 | Cite this Article
Rosita, L., Jannatin, N., Purwanto, B., Ratnaningsih, T., Sukorini, U., Simanjuntak, Z., Yuantari, R. 2021. Type of anemia correlate with ferritin levels in patients with Chronic Kidney Disease (CKD): a cross sectional study. Bali Medical Journal 10(3): 867-871. DOI:10.15562/bmj.v10i3.2418


Background: Anemia is the most common complication due to CKD. Normocytic normochromic is the most common type of anemia in CKD is, but there is also some microcytic hypochromic. Clinical examination such as erythrocyte indices examination and monitoring serum ferritin levels can help diagnose anemia in CKD. The purpose of this study is to determine the correlation between erythrocyte indices and ferritin levels in CKD patients in the hemodialysis unit of PKU Hospital Bantul.

Methods: This research involved 50 CKD patients at PKU Hospital Bantul. Blood samples were taken to check ferritin levels and erythrocyte indices consisting of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). This study was conducted by cross-sectional study design. Data were analyzed using SPSS version 20 for Windows.

Results: The average hemoglobin level was 8.46±1.31 g/dL in males and 7.92±0.90 g/dL in females. Most of the hematological profile was predominant in male patients such as in MCV (89.36±6.72 fl), MCH (29.12±2.76 pg), and MCHC (32.95±0.96 g/dL). However, the average ferritin level (352.51±544.74 ng/mL) was predominant in female patients (399.99±680.96 ng/mL). There was a significant correlation between MCH and ferritin levels (r = 0.364; p = 0.009) and MCHC with ferritin levels (r = 0.295; p = 0.038). However, there was no significant correlation between MCV and ferritin levels (r = -0.059, p = 0.683).

Conclusion: There is a significant correlation between MCH and MCHC levels with ferritin levels. In addition, the patients had normal MCV, MCH, and MCHC values with normocytic normochromic anemia. 

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