ORIGINAL ARTICLE

The dynamic of Soluble Vascular Cellular Adhesion Molecule -1 (sVCAM-1) level in Overnutritious children with Dengue Infection

Ni Kadek Elmy Saniathi , Mohammad Juffrie, Bambang Udji Djoko Rianto, Soetjiningsih Soetjiningsih

Ni Kadek Elmy Saniathi
Faculty of Medicine and Health science, Universitas Warmadewa, Denpasar-Bali, Indonesia. Email: [email protected]

Mohammad Juffrie
Pediatric Department Faculty of Medicine, Universitas Gadjah Mada/Sardjito General Hospital, Yogyakarta, Indonesia

Bambang Udji Djoko Rianto
Ear, Nose, and Throat-Head and Neck Department Faculty of Medicine, Universitas Gadjah Mada /Sardjito General Hospital, Yogyakarta, Indonesia

Soetjiningsih Soetjiningsih
Pediatric Department Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar-Bali, Indonesia
Online First: April 30, 2021 | Cite this Article
Elmy Saniathi, N., Juffrie, M., Rianto, B., Soetjiningsih, S. 2021. The dynamic of Soluble Vascular Cellular Adhesion Molecule -1 (sVCAM-1) level in Overnutritious children with Dengue Infection. Bali Medical Journal 10(1): 261-265. DOI:10.15562/bmj.v10i1.2304


Introduction: Dengue infection is still posed a significant medical challenge for pediatric population in developing countries. However, increased prevalence of overweight and obesity among children in those countries increased the possibility of the coexistence of these conditions. However, their interaction is still under investigated. Therefore, this study was aimed to study the dynamic of sVCAM-1 level as the known predictor of the severity of dengue infection with over nutritional status in children with dengue infection.

Method: An analytic observational nested case-control study was conducted in Paediatric Division Sanglah General Hospital, Bali. The children with DHF between 6 months old to 12 years old were included as the case group while control groups consisted of pediatric patients with just Dengue Fever (DF) with the same age range. The diagnosis of dengue was established using 1997 WHO criteria while nutritional status was assessed using WHO curve. The sVCAM-1 was evaluated using ELISA technique.

Results: The level of sVCAM-1 was significantly higher in patients with DHF than patients with DF only. The level was also fluctuated more in DHF patients. Likewise, the sVCAM-1 level was also significantly higher in DHF patients with overnutrition compared to normal DHF patients with a more fluctuated pattern over the course of 3 days (starting from day 4 to day 7). Finally, no significant finding was observed in sVCAM-1 level in DSS patients albeit the difference in concentration pattern.

Conclusion: Overnutrition is seems to be associated with higher concentration of sVCAM-1 and higher fluctuation of its concentration in children with DHF.

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