ORIGINAL ARTICLE

The correlation of blood thiamine concentrations with lactate acidosis in peritonitis patients with sepsis

Maria Meilita Sinaga , Vicky Sumarki Budipramana, Jusak Nugraha

Maria Meilita Sinaga
Department of Surgery, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, Indonesia. Email: [email protected]

Vicky Sumarki Budipramana
Department of Surgery, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, Indonesia

Jusak Nugraha
Department of Clinical Pathology, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, Indonesia
Online First: April 28, 2021 | Cite this Article
Sinaga, M., Budipramana, V., Nugraha, J. 2021. The correlation of blood thiamine concentrations with lactate acidosis in peritonitis patients with sepsis. Bali Medical Journal 10(1): 214-218. DOI:10.15562/bmj.v10i1.2237


Background: Vitamin B1 (Thiamine) functions as a pyruvate dehydrogenase cofactor to produce acetyl Co-A and activate the Krebs cycle in cellular metabolism. The hypermetabolic state in septic condition requires excess thiamin to keep the Krebs cycle functioning well. The thiamin level in the blood decreases and causes mitochondrial dysfunction and vice versa results in an increase in lactate levels. This study aims to evaluate the correlation of blood thiamine concentrations with lactate acidosis in peritonitis patients with sepsis

Methods: Prospective observational study in 65 adult septic patients who came to the hospital with peritonitis and underwent laparotomy. Thiamine concentration was assessed on days 1, 3, and 5 by liquid chromatography-mass spectrometry (LC-MS). The primary outcome was lactate levels. Data was analyzed using SPSS version 23 for Windows.

Results: The incidence of thiamine deficiency (TD) was 61.5% of patients. Specifically, 29 cases (44.6%) had absolute thiamine deficiency (TD) on presentation, 4 patients (6.1%) developed it on day 3, and another 7 patients (10.8%) on day 5. Thiamine was negatively correlated with lactate levels (r=-0.600; p=0.020). The relationship appeared after multivariable regression analysis controlling for sex, septic shock, and malnutrition. Overall, for the TD group, there was a significant association with septic shock, malnourishment, and Mortality (p<0.05).

Conclusion: Thiamine deficiency had significantly raised lactate levels, which might increase the risk of Mortality.

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