Background: Cardiovascular disease (CVD) has caused at least 1.1 million deaths per year globally. Heart and blood vessel disease are silent killer which can cause disability or death if left untreated. Stress on the walls of the blood vessels leads to hypertrophy and hyperplasia of the vascular smooth muscle causing endothelial damage and facilitating atherosclerosis. Endothelial dysfunction indirectly affects platelet (thrombocyte) function which has an important role in the formation of primary blockage. The formation of the primary blockage is influenced by the number and function of the thrombocyte and can be checked by biomarkers of thrombocyte, erythrocytes, and the ratio of thrombocyte -to-leukocytes. The purpose of this study was to analyze the relationship between erythrocytes, thrombocyte, and the ratio of thrombocyte-to- leukocyte (RTL).
Materials & Methods: Descriptive analytic design with a cross sectional approach was applied. Sixty CVD patients were examined for thrombocyte, erythrocytes, and ratio thrombocyte-to-leukocyte (RTL) based on routine hematological examinations. Data were tested for normality and checked with Pearson Correlation test. The research was conducted at the Dr. Kariadi Hospital for the period January-April 2020.
Results: Based on the statistical analysis test, the Pearson correlation test showed a moderate positive correlation between thrombocyte and RTL (p=<0.001; r=0.569), while the correlation between thrombocyte and erythrocytes were not significantly correlated (p=0.687; r=-0.046) in CVD patients.
Conclusion: There is a relationship between thrombocyte, and RTL values in CVD disease, so that thrombocyte biomarkers and RTL are suggested to be biomarkers in the management of CVD.