ORIGINAL ARTICLE

Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women

Dwi Ngestiningsih , Jessa Kris Dayanti, Lusiana Batubara

Dwi Ngestiningsih
Internal Medicine Department, Medical Biology and Biochemistry Department, Faculty of Medicine, Universitas Diponegoro- Dr. Kariadi Hospital, Semarang, Indonesia. Email: [email protected]

Jessa Kris Dayanti
General Practitioner, Research Assistant-Faculty of Medicine, Universitas Diponegoro-Dr. Kariadi Hospital, Semarang, Indonesia

Lusiana Batubara
Medical Biology and Biochemistry Department, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Online First: April 30, 2021 | Cite this Article
Ngestiningsih, D., Dayanti, J., Batubara, L. 2021. Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women. Bali Medical Journal 10(1): 336-339. DOI:10.15562/bmj.v10i1.2177


Background: The aging process is associated with an increase in proinflammatory markers' serum levels, indicating that a chronic inflammatory process is correlated with an increase in disability, mortality, and frailty. Pro-inflammatory cytokines that increase with the incidence of frailty syndrome are IL-6, IL-1β and TNF-α. 25-hydroxyvitamin D (25 (OH) D) deficiency is also a potential risk factor for frailty, especially in the elderly. Vitamin D deficiency is associated with a risk of falling, which can speed up the frailty process. The aim of the study is to determine the relationship between IL-6, IL-1β and Vitamin D on frailty status in elderly women in elderly integrated health services (posyandu lansia), Semarang City.

Methods: This study used a cross sectional design with a consecutive sampling method of 27 subjects. Subjects measured vital signs, weight and height measurements. The study subjects were then taken venous blood to measure the levels of IL-6, IL-1β and vitamin D in blood serum and assessed their frailty status. Data analysis using SPSS 25 with Spearman correlation test.

Results: There were 27 elderly women who followed this study with an average age of 67.93 years. There are 16 people with pre-frail status and 3 people with frail status. There is a significant relationship between vitamin D levels in serum and frailty status (p = 0.008; r = 0.497). Variables IL-6 (p=0.328) and IL-1β (p=0.095) had no significant relationship with frailty status.

Conclusion: Most of the elderly women have a pre-frailty status, namely as much as 59.3%. Vitamin D levels in the body have a significant and unidirectional relationship with frailty status in elderly women.

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