Alopecia areata (AA) is an autoimmune disease that causes hair loss, and its specific cause is not  fully determined. This disease affects the patients physically, psychologically, and cosmetically. Treatment of AA is not curative, but controls or limits the disease course. Most treatment modalities are an immunosuppressive or immunomodulatory agent, which are associated with increased side effects. PRP has been used in aesthetics and dermatology, especially for wound repair. Improvement characterized by hair growth has been reported in several studies. Hair growth improvement with PRP is an effective procedure for AA without any allergic reaction. Epidermal proliferation, induction of angiogenesis, and stimulation of the growth of follicular bulge cells were also reported. Despite showing the efficacy of PRP in AA, it is necessary to carry out randomized clinical trials and long-term evaluations to support the efficacy of therapy.

Otberg N, Shapiro J. Non-Scarring Focal Hair Loss. In: Hair Growth Disorders. Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s dermatology in general medicine, 8th ed. New York: McGraw-Hill; 2012. 991-994.

Amin SS, Sachdewa S. Alopecia areata: A review. Journal of the Saudi Society of Dermatology and Dermatologic Surgery. 2013;17:37-45.

Hordisky MK. Overview of Alopecia Areata. The society of Investigative Dermatology. 2013;16:1-2.

Signal A, Sonthania S, Verma P. Female Pattern Hair Loss. Indian Journal of Dermatology, Venereology and Leprology. 2013;79(5):627-640.

Ovidio RP. Alopecia Areata: A News On Diagnosis, Pathogenesis, and Treatment. G Ital Dermatology Venereology. 2014;149:25-45.

Kumar A, Sharma RP. Role of Platelet Rich Plasma Therapy in Alopecia Areata-A Prospective Study. International Journal of Contemporary Medical Research. 2016;3(8):2499-2502.

Langer C, Mahajan V. Platelet-Rich Plasma in Dermatology. JK Science. 2014;16(4):147-149.

Labusca LS, Cionca D. Clinical Review about the Role Of Platelet Rich Plasma for the Treatment of Traumatic and Degenerative Musculoskeletal Disorders. Orthopedics and Rheumatology Journal. 2016;2(3):1-9.

Wang E, Kevin J. Etiopathogenesis of Alopecia Areata; Why Do Our Patients Get It. Dermatologic Therapy. 2011; 24: 337-347.

Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, Seo YJ, Lee YH, Lee JH, Lee Y. Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg. 2012;38(7 Pt 1):1040-6.

Montero EC, Santos F, Fernadez S. Platelet-Rich Plasma: Application in Dermatology. Actas Dermosifiliogr. 2015;106(2):104-111.

Marlovits S, Mousavi M. Gabler C, Erdos J, Vecsei V. A new simplified technique for producing platelet-rich plasma: a short technical note. Eur Spine J. 2004;13(Suppl 1):S102-106.

Uebel CO, Escobar PD. Follicular Unit Megassesions and Platelet Growth Factor. Rev Bras Ur Plast. 2013;281:154-164.

Sammeling CE, Heyneman A. The Use of Platelet-Rich Plasma in Plastic Surgery, A Systemic Review. Journal of Plastic Reconstruction and Aesthetic Surgery. 2013;66:301-312.

Gentile P, Garcivich S, Bielli A. The Effect of Platelet Rich Plasma in Hair Regrowth ; A Randomized Placebo-Controlled Trial. Stem Cells Translational Medicine. 2015;4:1317-1323.

Lynch Md, Baschirs. Application of Platelet-Rich Plasma in Dermatology: a Critical Appraisal of The Literature. Journal of Dermatology Treatment. 2016;27(3):283-289.

Fukaya M, Ito A. A New Economic Method for Preparing Platelet-rich Plasma. Plast Reconstr Surg Glob Open. 2014;2(6):1-7.

Singhal P, Agarwal S, Dhot PS, Sayal SK. Efficacy of platelet-rich plasma in treatment of androgenic alopecia. Asian J Transfus Sci. 2015;9(2):159-62.

Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG, Orlandi A, Gentile P. The effect of autologous activated platelet-rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. 2014;2014:760709.

Maria-Angeliki G, Alexandros-Efstratios K, Dimitris R, Konstantinos K. Platelet-rich Plasma as a Potential Treatment for Noncicatricial Alopecias. Int J Trichology. 2015 Apr-Jun;7(2):54-63.

Messura MR, Nagata MJ. A Standardized Research Protocol for Platelet-Rich Plasma (PRP) Preparation in Rats. Original Research Article. 2011;8(3):299-304.

Maazoca DA, Beth M. Platelet-Rich Plasma Differs According to Preparation Method and Human Variability. The Journal of Bone and Joint Surgery. 2012;94(4):308-316.

Dhillion SR, Schaward EM. Platelet-Rich Plasma Therapy Future or Trend. Arthritis Research and Therapy. 2012;14:1-10.

Sommeling CE, Heyreman A. The Use of Platelet-Rich Plasma in Plastic Surgery: A Systematic Review. J Plast Reconstr Aesthet Surg. 2013;66:301-313.

Cole BJ, Soreyer ST. Platelet-Rich Plasma: Where Are Now And Where Are We Going. Sport Health Medicine. 2010;10(10):1-8.

Mubki T. Platelet-rich plasma combined with intralesional triamcinolone acetonide for the treatment of alopecia areata: A case report. Journal of Dermatology and Dermatology Surgery. 2016;20:87-90.

Uzzaif M, Vaaruni R. A Comparative Study of Treatment Modalities in Female Alopecia Areata. International Journal of Research in Medical Sciences. 2016;4(4):1229-1236.