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The correlation of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio compared to D-dimer as a diagnostic test in Deep Vein Thrombosis (DVT)

  • Kadek Yuda Sujana ,
  • I Nyoman Semadi ,
  • Tjokorda Gde Bagus Mahadewa ,


Abstract

Background: Deep vein thrombosis (DVT) is a blood clot that occurs in the inner veins caused by heart disease, infection, cancer, and prolonged immobilization of the limbs. Neutrophil-Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) have been known as a marker of the primary hemostasis process related to the inflammatory pathway. This study aims to evaluate the correlation of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio compared to D-dimer as a diagnostic test in Deep Vein Thrombosis (DVT)

Methods: A cross-sectional approach has been conducted in this diagnostic study at the Sanglah General Hospital by using secondary data from medical records during July 2018-2019. The study sample consisted of 49 patients with suspected DVT originating from a population who met the inclusion and exclusion criteria. The variables assessed in this study were NLR, PLR, and D-Dimer. Data collection and data analysis were performed by SPSS version 17 for Windows.

Results: The average age of respondents was 53.10±13.40 years old. Most of the respondents were male (59.20%), having edema in the lower extremity (61.20%), left unilateral laterality (53.10%), and D-Dimer levels ≥ 0,5 µg/ml (76.1%). There was a statistically significant relationship between the average value of NLR (9,07±4,2) and PLR (183,55±66,52) with the occurrence of DVT (P<0.05). The Area Under Curve (AUC) of ROC Analysis was 94.40% (Cut-off: 8.20; p<0.050) in NLR and 92.10% (Cut-off: 159.66) in PLR to the D-Dimer on the incidence of DVT. There was a significant moderate positive correlation between NLR and PLR combination on DVT incidences (r=0.532; p=0.001).

Conclusion:  NLR and PLR can be used as an alternative to DVT diagnostic tools due to high sensitivity and specificity, easy to use, inexpensive, simple, and widely available in Indonesia.

Keywords: NLR PLR D-Dimer DVT Diagnostic Test

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How to Cite

Sujana, K. Y., Semadi, I. N., & Mahadewa, T. G. B. (2020). The correlation of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio compared to D-dimer as a diagnostic test in Deep Vein Thrombosis (DVT). Bali Medical Journal, 9(2), 546–552. https://doi.org/10.15562/bmj.v9i2.1793
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Kadek Yuda Sujana
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I Nyoman Semadi
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Tjokorda Gde Bagus Mahadewa
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