Background:Â Deep vein thrombosis (DVT) is a blood clot that occurs in the inner veins caused by heart disease, infection, cancer, and prolonged immobilization of the limbs. Neutrophil-Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) have been known as a marker of the primary hemostasis process related to the inflammatory pathway. This study aims to evaluate the correlation of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio compared to D-dimer as a diagnostic test in Deep Vein Thrombosis (DVT)
Methods:Â A cross-sectional approach has been conducted in this diagnostic study at the Sanglah General Hospital by using secondary data from medical records during July 2018-2019. The study sample consisted of 49 patients with suspected DVT originating from a population who met the inclusion and exclusion criteria. The variables assessed in this study were NLR, PLR, and D-Dimer. Data collection and data analysis were performed by SPSS version 17 for Windows.
Results:Â The average age of respondents was 53.10Â±13.40 years old. Most of the respondents were male (59.20%), having edema in the lower extremity (61.20%), left unilateral laterality (53.10%), and D-Dimer levels â‰¥ 0,5 Âµg/ml (76.1%). There was a statistically significant relationship between the average value of NLR (9,07Â±4,2) and PLR (183,55Â±66,52) with the occurrence of DVT (P<0.05). The Area Under Curve (AUC) of ROC Analysis was 94.40% (Cut-off: 8.20; p<0.050) in NLR and 92.10% (Cut-off: 159.66) in PLR to the D-Dimer on the incidence of DVT. There was a significant moderate positive correlation between NLR and PLR combination on DVT incidences (r=0.532; p=0.001).
Conclusion:Â NLR and PLR can be used as an alternative to DVT diagnostic tools due to high sensitivity and specificity, easy to use, inexpensive, simple, and widely available in Indonesia.