ORIGINAL ARTICLE

Lecithin- cholesterol acyltransferase and relationship with Platelet-activating factor in AB blood phenotype

Suayip Birinci, Belkis Koctekin, Necat Yilmaz

Suayip Birinci
Deputy Minister of Health Department of Health Informatics, Ankara,Turkey

Belkis Koctekin
Department of Physiology and Transfusion Center, Antalya Training and Research Hospital, Antalya, Turkey

Necat Yilmaz
Department of Clinical Chemistry and LC/MS-MS Laboratory, Antalya Training and Research Hospital, Antalya, Turkey. Email: [email protected]
Online First: April 01, 2020 | Cite this Article
Birinci, S., Koctekin, B., Yilmaz, N. 2020. Lecithin- cholesterol acyltransferase and relationship with Platelet-activating factor in AB blood phenotype. Bali Medical Journal 9(1): 184-190. DOI:10.15562/bmj.v9i1.1746


Objectives: This study aimed to determine the association between Lecithin-cholesterol acyltransferase (LCAT) and Platelet-activating factor (PAF) with atherogenic potential in the ABO blood system.

Background: The current study is the first study that focuses on healthy blood donors and investigating a relationship between ABO blood groups and LCAT enzyme and PAF, which plays a notable role in atherogenesis.

Methods: ABO blood types characterize the role of the individualistic phenotype. Hence, it is generally assumed that ABO blood phenotypes are involved with many diseases. This cross-sectional study involved 176 healthy subjects with different ABO blood phenotypes. Measurements of routine lipids, LCAT, PAF and atherogenic plasma index (AIP) were performed in these subjects.

Results: Our most important finding was that individuals with blood group AB have statistically significant lower LCAT levels in serum. Additionally, there was a moderately negative correlation between LCAT and triglycerides in the AB blood phenotype (r=-0.452, P=0.02). Nevertheless, there were statistically significant correlations between LCAT levels and PAF levels of subjects with only non –O blood phenotypes (A, B and AB). Serum AIP values were statistically significantly higher in the AB blood group.

Conclusion: The present study suggests that blood group AB can be associated with decreased LCAT   levels when compared to the non- AB phenotypes. We suggest that LACT and AIP may be helpful biomarkers to illustrate atherogenic risk in AB blood phenotype, although this requires further investigation.

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