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The small volume subcutaneous polyalkylimide injection-induced collagen capsule in rats: A preliminary study

Abstract

Background: Polyalkylimide is a permanent dermal filler that has been used for skin augmentation to ameliorate skin ageing. The massive volume injection has a higher risk of complication. This study aims to find collagen capsule formation by small volume polyalkylimide implantation.  

Methods: We used an experimental post-test only control group design. The control group received subcutaneous NaCl injection, and the treatment group received subcutaneous polyalkylimide injection 0.018 mL (equal 1 mL in the humans). After five weeks, all rats (Rattus norvegicus) strain Wistar were sacrificed. The skin samples were collected and proceed for histologic staining. Capsule thickness was performed as mean ± SD.     

Results: The treatment group showed polyalkylimide mass in subcutaneous tissue, collagen fibres surrounding the polyalkylimide, and no inflammatory cells. The collagen capsule thickness was 7.45 ± 0.78 µm.

Conclusion: The small volume polyalkylimide subcutaneous injection-induced collagen capsule formation. The small volume implantation shows promising effects for skin augmentation.

References

  1. Zhang S, Duan E. Fighting against skin ageing: The way from bench to bedside. Cell Transplantation. 2018; 27(5):729-738.
  2. Cheng LY, Sun XM, Tang MY, Jin R, Cui WG, Zhang YG. An update review on recent skin fillers. Plast Aesthet Res. 2016;3:92-9.
  3. Lahiri A, Waters R. Experience with Bio-Alcamid, a new soft tissue endoprosthesis. Journal of Plastic, Reconstructive and Aesthetic Surgery. 2007; 60:663-667.
  4. Schelke LW, van Den Elzen HJ, Canninga M, Neumann M. Complications after treatment with polyalkylimide. Dermatologic Surgery, 35:1625-1628. DOI: 10.1111/j.1524-4725.2009.01340.x
  5. Sattler T, Tobbia D, Witulski C. A series of complications after treatment of pectus excavatum with polyalkylimide gel (Bio-Alcamid). The Aesthetic Meeting 2013, New York.
  6. Jacono AA. The face of the future: Look natural, not plastic. A less-invasive approach to enhance your beauty and reverse facial ageing. Addicus Books.
  7. Lin ZY, Shah V, Dhinakar A, Yildirimer L, Cui WG, Zhao X. Intradermal fillers for minimally invasive treatment of facial ageing. Plast Aesthet Res, 2016, 3:72-82.
  8. Bray D., Hopkins C., Roberts D. N. A review of dermal fillers in facial plastic surgery. Cur Opin Otolaryngol Head Neck Surg, 2010, 18:295-302.
  9. Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clinical, Cosmetic, and Investigational Dermatology, 2013, 6:295-316.
  10. Gálvez FU, Delgado NE, Figueiredo V, Lajo-Plaza JV, Mira M, Moreno A, Marti FO, del Rio-Reyes R, Alvarez NR, del Cueto SR, Segurado MA, Rebenaque CV. Treatment of soft tissue filler complications: expert consensus recommendations. Aesth Plast Surg, 2018, 42:498-510.
  11. Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol. 2008; 20(2):86-100.
  12. Claudette GJCA de Vries & Robert E Geertsma. Clinical data on injectable tissue fillers: a review, Expert Review of Medical Devices, 2013, 10:6, 835-853, DOI:10.1586/17434440.2013.839211
  13. Cheng LY, Sun XM, Tang MY, Jin R, Cui WG, Zhang YG. An update review on recent skin fillers. Plast Aesthet Res 2016;3:92-9
  14. Nathoo NA, Rasmussen S, Dolman PJ, Rossman DW. Periocular mass lesions secondary to dermatologic fillers: report of 3 cases. Canadian Journal of Opthalmology, 2014, 49(5):468-472.
  15. Loutfy MR, Brunetta J, Kovacs C, Diong C, Gamble M, Antoniou T, Smith G, Halpenny R, Rosenes R, Raboud JM. Four-year follow-up of polyalkylimide gel use for the treatment of HIV-associated lipoatrophy. HIV Clinical Trials, 2011, 12(6):323-332.
  16. Ramires PA, Miccoli MA, Panzarini E, Dini L, Protopapa C. In vitro and in vivo biocompatibility evaluation of a polyalkylimide hydrogel for soft tissue augmentation. J Biomed Mater Res Part B: Appl Biomater. 2005; 72B:230-238.
  17. Ellis D, Sardesai MG. Bio-Alcamid: An alternative to fat transfer. Facial Plast Surg Clin N Am. 2008; 16:429-433.
  18. Kadouch JA, Vos W, Nijhuis EWP, Hoekzema R. Granulomatous foreign-body reactions to permanent fillers. Detection of CD123+ plasmacytoid dendritic cells. The American Journal of Dermatology, 2015, 37(2):107-114.
  19. Schelke LW, Velthuis PJ, van Dijk MR. Polyalkylimide. A nonstable filler over time. Dermatologic Surgery, 2018, 44(4):563-567.
  20. Mundada P, Kohler R, Boudabbous S, Trellu LT, Platon A, Becker M. Injectable facial fillers: imageing features, complications, and diagnostic pitfalls at MRI and PET CT. Insights Imageing, 2017, 8:557-572.
  21. Quan T, Wang F, Shao Y, Rittie L, Xia W, Orringer JS, Voorhees JJ, Fisher GJ. Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo. J Invest Dermatol, 2013, 133(3):658-667.
  22. Liew S, Wu WTL, Chan HH, Ho WWS, Kim HJ, Goodman GJ, Peng PHI, Rogers JD. Consensus on changing trends, attitudes, and concepts of Asian beauty. Aesth Plast Surg, 2016, 40:193-201.
  23. Wu WTL, Liew S, Chan HH, Ho WWS, Supapannachart N, Lee HK, Prasetyo A, Yu JN, Rogers JD. Consensus on current injectable treatment strategies in the Asian face. Aesth Plast Surg, 2016, 40:202-214.
  24. Vashi NA, Maymone MBDC, Kundu RV. Ageing differences in ethnic skin. J Clin Aesthet Dermatol, 2016, 9(1):31-38.

How to Cite

Tanuwidjaja, T. (2020). The small volume subcutaneous polyalkylimide injection-induced collagen capsule in rats: A preliminary study. Bali Medical Journal, 9(1), 395–399. https://doi.org/10.15562/bmj.v%vi%i.1722

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