ORIGINAL ARTICLE

Diagnostic test of thorax computed tomography scanning in lung tumors against cytopathological results at Zainoel Abidin Hospital, Banda Aceh, Indonesia period June - August 2018

Indrita Iqbalawaty , Muhammad Yani, Nurul Machillah, Fajriah Fajriah, Asnawi Abdullah, Teuku Muhammad Ilzana, Cut Rizka Rahmi, Teuku Muhammad Khaled, Dara Purnamasari

Indrita Iqbalawaty
Radiology Department, Faculty of Medicine, Universitas Syiah Kuala-Zainoel Abidin General Hospital, Banda Aceh-Indonesia. Email: [email protected]

Muhammad Yani
Public Health Department, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh-Indonesia

Nurul Machillah
Radiology Department, Faculty of Medicine, Universitas Syiah Kuala-Zainoel Abidin General Hospital, Banda Aceh-Indonesia

Fajriah Fajriah
Pathology Department, Faculty of Medicine, Universitas Syiah Kuala – Zainoel Abidin General Hospital, Banda Aceh-Indonesia

Asnawi Abdullah
Faculty of Public Health, Universitas Muhammadiyah, Banda Aceh-Indonesia

Teuku Muhammad Ilzana
Faculty of Public Health, Universitas Muhammadiyah, Banda Aceh-Indonesia

Cut Rizka Rahmi
Faculty of Public Health, Universitas Muhammadiyah, Banda Aceh-Indonesia

Teuku Muhammad Khaled
Radiology Department, Faculty of Medicine, Universitas Syiah Kuala-Zainoel Abidin General

Dara Purnamasari
Insurance Installation, Zainoel Abidin General Hospital, Banda Aceh-Indonesia
Online First: December 19, 2019 | Cite this Article
Iqbalawaty, I., Yani, M., Machillah, N., Fajriah, F., Abdullah, A., Ilzana, T., Rahmi, C., Khaled, T., Purnamasari, D. 2019. Diagnostic test of thorax computed tomography scanning in lung tumors against cytopathological results at Zainoel Abidin Hospital, Banda Aceh, Indonesia period June - August 2018. Bali Medical Journal 8(3): 930-933. DOI:10.15562/bmj.v8i3.1690


Introduction: Lung cancer which is a major cause of cancer deaths provides a perspective on the importance of the diagnosis of cancer since there is suspicion that influences the clinical diagnosis of lung cancer. Imaging modalities such as the use of contrast CT-Scan are very helpful in giving initial imaging before confirming cytopathological examination. The purpose of this study was to determine the value of the diagnostic tests possessed by CT-Scan compared to the gold standard cytopathological examination in patients with clinical diagnosis of lung cancer.

Methods: This study used a diagnostic study design with a retrospective approach at Zainoel Abidin General Hospital, Banda Aceh-Indonesia during the period June - August 2018. Analysis of diagnostic tests using cross-tabulation then calculation of sensitivity, specificity, positive predictive value (PPV), negative predictive calculations value (NPV), positive likelihood ratio (LR +), negative likelihood ratio (LR-), and accuracy were performed.

Results: Most CT-scan findings were pulmonary mass (59.3%) and the most cytopathological findings were squamous cell carcinoma (47.5%). The CT-Scan diagnostic test value compared with the gold standard cytopathological examination in the form of sensitivity, specificity, PPV, NPV, LR +, LR-, and accuracy was 75%, 30.4%, 64.4%, 50%, 0.054, 0.822 and 61% respectively.

Conclusion: Lung cancer could manifest as a wide spectrum of radiological presentations. CT-Scan provide a high sensitivity and accuracy of diagnostic in person with clinical presentation of lung cancer.

 

References

Makaju S, Prasad PWC, Alsadoon A, Singh AK, Elchouemi A. Science Direct Procedia Computer Science Lung Cancer Detection using CT Scan Images. Procedia Comput Sci. 2018;125(2009):107-114. doi:10.1016/j.procs.2017.12.016.

Larici AR, Farchione A, Franchi P, et al. Lung nodules : size still matters. Eur Respir Rev. 2017; 26: 170025. 2017. doi:10.1183/16000617.0025-2017.

Nasim F, Sabath BF, Eapen GA. Lung Cancer Lung cancer Smoking Screening Staging Chemotherapy. Med Clin NA. 2019;103(3):463-473. doi:10.1016/j.mcna.2018.12.006.

Williams K, Probst H. Radiography Use of IV contrast media in radiotherapy planning CT scans : A UK audit. Radiography. 2016:1-5. doi:10.1016/j.radi.2016.06.006.

McCollough CH, Bushberg JT, Fletcher JG, Eckel LJ. Answers to Common Questions About the Use. Mayo Clin Proc. 2015;90(10):1380-1392. doi:10.1016/j.mayocp.2015.07.011.

Gao C, Xiang P, Ye J, Pang P, Wang S, Xu M. Can texture features improve the differentiation of infiltrative lung adenocarcinoma appearing as ground glass nodules in contrast-enhanced CT ?. Eur J Radiol. 2019;117:126-131. doi:10.1016/j.ejrad.2019.06.010.

Bodor JN, Feliciano JL, Edelman MJ. Lung Cancer Outcomes of patients with disease recurrence after treatment for locally advanced non-small cell lung cancer detected by routine follow-up CT scans versus a symptom driven evaluation. Lung Cancer. 2019;135:16-20. doi:10.1016/j.lungcan.2019.07.009.

Hossain R, Wu CC, Groot PM De, Carter BW, Gilman MD, Abbott GF. Missed Lung Cancer Lung cancer Lung nodule Chest radiography Computed tomography Observer performance. Radiol Clin NA. 2018:1-11. doi:10.1016/j.rcl.2018.01.004.

Hinde S, Crilly T, Balata H, et al. Lung Cancer The cost-e ff ectiveness of the Manchester ‘ lung health checks ’ , a community- based lung cancer low-dose CT screening pilot. Lung Cancer. 2018;126:119-124. doi:10.1016/j.lungcan.2018.10.029.

Shieh Y, Bohnenkamp M. Low-dose computed tomography for lung cancer screening: clinical and coding considerations. Chest. 2017. doi:10.1016/j.chest.2017.03.019.

Yankelevitz DF, Yip R, Smith JP, Liang M, Liu Y, Xu DM, et al. CT screening for lung cancer: non-solid nodules in baseline and annual repeat rounds. Radiology 2015;277:555-64.

Cohen JG. Remond E, Jankowski A, Brambilla E, et al. Lung adenocarcinoma: correlation of Comtued tomography and pathology findings. Diagnostic and interventional Imaging. 2016. http://dx.doi.org/10.1016/j.diii.2016.06.021.

Lederlin M, Puderbach M, Muley T, Schnabel PA, Stenzinger A, Kauczor HU, et al. Correlation of radio- and histomorphological pattern of pulmonary adenocarcinoma. Eur Respir J. 2013;41:943-51.

Lee SM, Park CM, Goo JM, Lee HJ, Wi JY, Kang CH. Invasive pulmonary adenocarcinomas versus preinvasive lesions appearing as ground-glass nodules: differentiation by using CT features. Radiology. 2013;268:265-73.

Lee HJ, Goo JM, Lee CH, Park CM, Kim KG, Park EA, et al. Predictive CT findings of malignancy in ground-glass nodules on thin-section chest CT: the effects on radiologist performance. Eur Radiol. 2009;19:552-60.


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