REVIEW

Comparing the effect of Angiotensin-Converting Enzyme Inhibitors versus Angiotensin Receptor Blockers in heart failure patients with type 2 diabetes mellitus: a systematic review

Ratih Puspita Febrinasari , Bambang Irawan Martohusodo, Erna Kristin, Ricvan Dana Nindrea, Iwan Dwiprahasto

Ratih Puspita Febrinasari
Doctoral Program Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia Department of Pharmacology and Therapy, Faculty of Medicine Universitas Sebelas Maret, Surakarta, Indonesia. Email: [email protected]

Bambang Irawan Martohusodo
Department of Cardiology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia;

Erna Kristin
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia;

Ricvan Dana Nindrea
Doctoral Program Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia Department of Public Health and Community Medicine, Faculty of Medicine Universitas Andalas, Padang, Indonesia.

Iwan Dwiprahasto
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia
Online First: December 01, 2019 | Cite this Article
Febrinasari, R., Martohusodo, B., Kristin, E., Nindrea, R., Dwiprahasto, I. 2019. Comparing the effect of Angiotensin-Converting Enzyme Inhibitors versus Angiotensin Receptor Blockers in heart failure patients with type 2 diabetes mellitus: a systematic review. Bali Medical Journal 8(3). DOI:10.15562/bmj.v8i3.1534


Abstract:

Introduction: Heart failure is a prevalent world wide. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are widely prescribed. The aim of this study was to determine the effect of the two drugs in heart failure patients with type 2 diabetes mellitus.

Methods: This meta-analysis was performed on research articles on the drugs of heart failure patients in PubMed, ProQuest and EBSCO database published between 2008-2018. Pooled odds ratio (OR) are calculated using fixed and random effects models. Data were processed using Review Manager 5.3 (RevMan 5.3).

Results: From total 209 articles, 10 studies met the criteria for systematic review. Meta-analysis result showed that there were no difference effect of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in heart failure patients with type 2 diabetes mellitus (RR = 1.73 [95% CI 0.88-3.40], p=0.11). Heterogeneity test for studies (Pheterogeneity = <0.00001) showed variation of heterogeneous research. There is no publication bias on this study Egger’s test (p = 0.334) and Begg’s test (p = 0.180).

Conclusion: This analysis confirmed there were no difference effect of angiotensin-converting enzyme inhibitors (ACEi) versus angiotensin receptor blockers (ARBs) in heart failure patients with type 2 diabetes mellitus

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