Correlation of Interleukin-6 serum level and surgical site infection in post major surgery patient

Supomo Supomo

doi:10.15562/bmj.v8i1.1004

Correlation of Interleukin-6 serum level and surgical site infection in post major surgery patient

Supomo Supomo ,

PDF |
DOI: https://doi.org/10.15562/bmj.v8i1.1004 |
Published: 2018-10-03

Abstract

Background: Surgical site infections (SSI) are a common surgery complication which early diagnosis is important to initiate an adequate therapy promptly. Objective: To explore the possibility of using serum Interleukin-6 (IL-6) in patients who had major surgery as a biomarker to predict SSI. Patients and Methods: From October to December 2011, 50 patients who underwent major surgery in Sardjito General Hospital Department of Surgery, Yogyakarta were followed up for their IL-6 serum on the third day following the surgery. The patients were also assessed whether they contracted SSI or not. Results: SSI was present in sixteen out of 45 patients (35.6%). The serum IL-6 level was higher in the group which SSI present where 84.5% of the sample was higher than 10 pg/ml. The Chi-square test showed SSI is related to abnormal IL-6 level (OR 4.941, p<0.05). Conclusion: Post-operative IL-6 higher than normal serum level was associated with SSI. The result indicates that IL-6 serum level may be a useful predictor of the occurrence of SSI in patients who underwent major surgery.

References

Hunziker BS, Schuchardt K, Groeschl I, Schuetz P, Mueller B, Dick W, et al. The Value of Serum Procalcitonin Level for Differentiation of Infectious from Noninfectious Causes of Fever after Orthopaedic Surgery. The Journal of Bone and Joint Surgery. American Volume.2010 Jan; 92(1):138-148.
Luisa M, Morsillo F, Tangenti M, Pirazzini MC, Ragni P. Rates of Surgical-Site Infection : An International Comparasion. Infection Control and Hospital Epidemiology. 2005 May;26(5): 442-448
Collier M, Evans D, Farrington M, Gibbs E, Gould K, Jenkinson H, et al.Surgical site infection: prevention and treatment of surgical site infection. Nice Clinical Guideline 74, National Institute for Health and Clinical Excellence.2008 Oct.
Castelli GP, Pognani C, Meisner M, Stuani A, Bellomi D, Sgarbi L. Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. Critical Care. 2004 Jun 10; 8(4): 234-242.
Hunziker BS, Schuchardt K, Groeschl I, Schuetz P, Mueller B, Dick W, et al. The Value of Serum Procalcitonin Level for Differentiation of Infectious from Noninfectious Causes of Fever after Orthopaedic Surgery. The Journal of Bone and Joint Surgery. American Volume.2010 Jan; 92(1):138-148.
Paul, E, Eric C, Charles, C. Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip. The Journal of bone and joint Surgery. American Volume. 2005 Sep; 87(9): 1921-1927.
Zelzer S, Aigner RM, Khoschsorur G, Hofer HP, Schaur RJ, Foldes-papp Z. Comparative Study of the Immunological Marker IL-6 and the Non- Immunological Marker PCT in Surgery Patients with Infections and Multiple Trauma. The Open Pathology Journal. 2009; 3: 124-130.
Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Center for Disease Control and Prevention. 1999 Apr; 20(4): 247-278.
Jawa RS, Anillo S, Huntoon K, Baumann H, Kulaylat. Interleukin-6 in surgery, Trauma, and Critical Care Part II: Clinical Implications. Journal of Intensive Care Medicine; 26(2): 73-87.
10 Sander M, Heymann CV, Dossow VV, Spaethe C, Konertz WF, Jain U, et al. Increased Interleukin-6 After Cardiac Surgery Predicts Infection. The International Anesthesia Research Society. 2006; 102:1623-1929.
Mokart D, Merlin M, Sannini A, Brun JP, Delporo JR, Houvenaeghel D, et al. Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. British Journal of Anaesthesia. 2005 Jun; 94(6): 767-773.

[1] Hunziker BS, Schuchardt K, Groeschl I, Schuetz P, Mueller B, Dick W, et al. The Value of Serum Procalcitonin Level for Differentiation of Infectious from Noninfectious Causes of Fever after Orthopaedic Surgery. The Journal of Bone and Joint Surgery. American Volume.2010 Jan; 92(1):138-148.

[2] Luisa M, Morsillo F, Tangenti M, Pirazzini MC, Ragni P. Rates of Surgical-Site Infection : An International Comparasion. Infection Control and Hospital Epidemiology. 2005 May;26(5): 442-448

[3] Collier M, Evans D, Farrington M, Gibbs E, Gould K, Jenkinson H, et al.Surgical site infection: prevention and treatment of surgical site infection. Nice Clinical Guideline 74, National Institute for Health and Clinical Excellence.2008 Oct.

[4] Castelli GP, Pognani C, Meisner M, Stuani A, Bellomi D, Sgarbi L. Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. Critical Care. 2004 Jun 10; 8(4): 234-242.

[5] Hunziker BS, Schuchardt K, Groeschl I, Schuetz P, Mueller B, Dick W, et al. The Value of Serum Procalcitonin Level for Differentiation of Infectious from Noninfectious Causes of Fever after Orthopaedic Surgery. The Journal of Bone and Joint Surgery. American Volume.2010 Jan; 92(1):138-148.

[6] Paul, E, Eric C, Charles, C. Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip. The Journal of bone and joint Surgery. American Volume. 2005 Sep; 87(9): 1921-1927.

[7] Zelzer S, Aigner RM, Khoschsorur G, Hofer HP, Schaur RJ, Foldes-papp Z. Comparative Study of the Immunological Marker IL-6 and the Non- Immunological Marker PCT in Surgery Patients with Infections and Multiple Trauma. The Open Pathology Journal. 2009; 3: 124-130.

[8] Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Center for Disease Control and Prevention. 1999 Apr; 20(4): 247-278.

[9] Jawa RS, Anillo S, Huntoon K, Baumann H, Kulaylat. Interleukin-6 in surgery, Trauma, and Critical Care Part II: Clinical Implications. Journal of Intensive Care Medicine; 26(2): 73-87.

[10] 10 Sander M, Heymann CV, Dossow VV, Spaethe C, Konertz WF, Jain U, et al. Increased Interleukin-6 After Cardiac Surgery Predicts Infection. The International Anesthesia Research Society. 2006; 102:1623-1929.

[11] Mokart D, Merlin M, Sannini A, Brun JP, Delporo JR, Houvenaeghel D, et al. Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. British Journal of Anaesthesia. 2005 Jun; 94(6): 767-773.

Correlation of Interleukin-6 serum level and surgical site infection in post major surgery patient

Abstract

References

How to Cite

Search Panel